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Matches 1 - 50 out of 4,200

Document Document Title
WO/2022/166890A1
Substituted pyridazine phenol derivatives and a preparation method therefor, specifically relating to a compound as shown in formula (VI) and a pharmaceutically acceptable salt thereof, which can be used as an NLRP3 inhibitor.  
WO/2022/160637A1
A 3-aryl-6-aralkyl-1,4,5,6-tetrahydropyridazine compound, having the structure as shown in formula I. γ, δ-unsaturated N-aryl sulfonyl substituted hydrazone is subjected to a cyclization rearrangement reaction by means of a light and r...  
WO/2022/157686A1
The present invention relates to a new compound that can inhibit an anoctamin 6 protein, a composition comprising the compound, a method for preparing the compound, and a method for using the compound or composition.  
WO/2022/152852A1
This application relates to compounds of Formula (I), which are antagonists of MrgX2 (Mas-related Gene X2) and thus are useful as therapeutic agents, specifically therapeutic agents for use in the treatment of chronic spontaneous urticar...  
WO/2022/150756A1
An improved process for the preparation of high purity Levosimendan includes treatment of Levosimendan crude with an organic acid, adding an organic acid to precipitate Levosimendan and isolating pure Levosimendan from the precipitate. L...  
WO/2022/149618A1
The present invention provides a method for producing a compound having alkylated acidic functional groups. The method includes alkylating acidic functional groups by reacting, in a mixture containing a compound having two or more types ...  
WO/2022/149617A1
The present invention provides a library which comprises from 1 × 102 to 1 × 108 compounds; the compounds have a structure in which a first core block (first CB), a first linker (first L) and a second core block (second CB) are covalen...  
WO/2022/143695A1
The present invention relates to a sulfonamide inhibitor, and a preparation method therefor and an application thereof. Specifically, the compound of the present invention has a structure as represented by formula (I). Also disclosed in ...  
WO/2022/136206A1
A Process for the Preparation of N-(bis(4-methoxyphenyl)methyl)-6-oxo-2-(pyridazin-3-yl)-1,6- dihydropyrimidine-5-carboxamide with improved reaction conditions and reduced use of toxic reagents and solvents.  
WO/2022/140309A1
Disclosed are compounds of Formula 1, including all stereoisomers, A-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides wherein R1, R2, R3, R4, R14, and X are as defined in the disclosure, A ...  
WO/2022/135567A1
A pyridazine-containing compound and a medicinal use thereof. Specifically, a compound represented by formula I or a medicinal salt thereof. The compound or the medicinal salt thereof has an NLRP3 inflammasome inhibiting activity, and ca...  
WO/2022/122773A1
The present invention relates to 4-(2-Fluoro-4-methoxy-5-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl) carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid derivatives and similar compounds of formula (I) as R...  
WO/2022/121517A1
Disclosed are a compound as a sodium channel regulator and the use thereof. The compound has obvious inhibition and blocking effects on the activity of the voltage-gated sodium ion channel subtype Nav1.8 ion channel, and can be used as a...  
WO/2022/121868A1
A TYK2 inhibitor compound containing an amide group and a heterocycloalkyl group and a preparation method therefor, and the present invention relates to a use thereof in the preparation of a drug for treating or preventing TYK2-related d...  
WO/2022/112493A1
The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are phthalazine derivatives, methods of preparing such compounds, pharmaceutical compositions c...  
WO/2022/091091A1
The present invention relates to polymers comprising bifunctional mono- or polycyclic heterocyclic or heteroaromatic repeating units having disinfecting activity, compositions thereof, and methods for disinfecting surfaces utilizing said...  
WO/2022/090762A1
The present invention concerns dispiroindenopyridines and dispiroindenopyridazines and derivatives thereof, methods for their preparation, the study and definition of their properties, and their uses. In particular, the present invention...  
WO/2022/093919A1
Disclosed are compounds and their pharmaceutically acceptable salts that possess inhibitory activity against EXO1, and methods of using the compounds and salts to treat cancer and precancerous conditions.  
WO/2022/084334A1
The present invention relates to compositions comprising as component (A) at least one compound of formula (I), or an agrochemically acceptable salt thereof wherein R1 is (II) or (III) and, as component (B), at least one compound, or agr...  
WO/2022/083706A1
Provided are a series of salts of FXIa inhibitor compounds, pharmaceutical compositions containing said compounds, and a use of said compounds in drugs for the treatment of diseases such as thromboembolism.  
WO/2022/084335A1
The present invention relates to compositions comprising as component (A) a compound of formula (I) or an agrochemically acceptable salt thereof wherein R1 is H or methyl; and as component (B) at least one compound, or agrochemically acc...  
WO/2022/083707A1
Provided is a pharmaceutical use of an FXIa inhibitor compound or a salt thereof. Specifically, provided is a use of the FXIa inhibitor compound or the salt thereof in preparation of drugs for prevention and/or treatment of arterial and ...  
WO/2022/087141A1
The disclosure describes a method of preparing pyridazinone derivatives comprising contacting a compound of formula (I) or a salt thereof: (I) with a compound of formula (II) or a salt thereof: (II) to form a compound of formula (III) or...  
WO/2022/068915A1
Provided are a 6-oxo-1,6-dihydropyridazin derivative, a preparation method therefor, and an application thereof in medicine. Specifically, the present invention relates to a 6-oxo-1,6-dihydropyridazin derivative as shown by general formu...  
WO/2022/063896A1
The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and...  
WO/2022/063876A1
The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and...  
WO/2022/058785A1
The invention relates to new olaparib oxalic acid cocrystals. The olaparib oxalic acid cocrystals vary in ratio from 1:1 to 2:3 olaparib: oxalic acid. In particular, the invention relates to a 2:3 olaparib oxalic acid cocrystal, a 1:1 ol...  
WO/2022/040747A1
The present invention relates to compounds that have zinc and/or iron ionophore activity and their use in treating diseases that are modulated by reducing zinc and/or iron. In particular embodiments, the compounds are compounds of formul...  
WO/2022/037647A1
Provided are a crystalline form of a selective NaV inhibitor and a preparation method therefor. Specifically, provided are crystalline forms A to E of the compound 4-((4-(5-chloro-2-(4-fluoro-2-(methoxy-d 3)phenoxy)-4-(trifluoromethyl)be...  
WO/2022/036204A1
The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodru...  
WO/2022/032484A1
Disclosed in the present invention are a pyridazine-3-formamide compound suitable for inhibiting or regulating the Janus kinase (JAK), in particular tyrosine kinase 2 (TYK2), and a preparation method therefor and the medical use thereof....  
WO/2022/032144A1
Provided herein are compounds that modulate PRTM5 activity. The compounds may inhibit the binding PRMT5 with a PRMT5 substrate adaptor. The compounds can modulate PRMT5 methyltransferase activity, modulate transcription of a gene regulat...  
WO/2022/026500A1
Disclosed are compounds of Formula 1, all stereoisomers, N-oxides and salts thereof, wherein G is CONR5R6 or selected from and R1 through R18 Rf and G are as defined in the Disclosure. Also disclosed are compositions containing the compo...  
WO/2022/026465A1
The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating ca...  
WO/2022/017494A1
The present invention relates to a crystal form of a pyridazine derivative free base and a preparation method therefor and the use thereof. Specifically, the present invention relates to a compound as represented by general formula (I), ...  
WO/2022/016345A1
Disclosed is an application of a composition for preventing and/or eliminating platelet aggregation in an in vitro blood sample. The composition comprises at least one compound selected from the group consisting of formula (I) and a salt...  
WO/2022/002860A1
The use of P2X4 antagonists for the treatment of dry eye syndrome, more in particular substituted N-phenylacetamide compounds of general formula (I), pharmaceutical compositions and combinations comprising said compounds for use in the t...  
WO/2022/002859A1
Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and ...  
WO/2021/261563A1
In the production of crops in agriculture, horticulture and the like, the occurrence of damages by pests and the like has been still a major issue, and therefore the development of novel agricultural/horticultural insecticides has been d...  
WO/2021/260609A1
The invention relates to a novel process, novel process step(s) and novel intermediate(s) useful for the preparation of 1,4-disubstituted pyridazine compounds, such as 5-(1 H-Pyrazol-4-yl)-2-(6- ((2,2,6,6-tetramethylpiperidin-4-yl)oxy)py...  
WO/2021/223650A9
The present application relates to a nitrogen-containing compound. The structural formula of the nitrogen-containing compound is as shown in formula I, in which ring A and ring B are each independently selected from a benzene ring or a f...  
WO/2021/256900A1
The present invention relates to a novel oxopyridazinyl-phenyl-carbonohydrazonoyl dicyanide compound and a use thereof.  
WO/2021/250466A1
The present disclosure includes certain substituted (phthalazin-1-ylmethyl)ureas, N- (phthalazin-1-ylmethyl)amides, and analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV)...  
WO/2021/249995A1
The present disclosure relates to azabicyclyl-substituted heterocyclic compounds of formula (I), wherein A1, A2, m, R3, R4, R5, L, R6, T, the ring Y, p, R7 and Q have the meanings as defined in the specification, to compositions comprisi...  
WO/2021/247634A1
Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labele...  
WO/2021/244391A1
Provided in the present invention is a small-molecule GLP-1R agonist, which is a compound of general formula (I), or a pharmaceutically acceptable salt, stereoisomer, ester, prodrug, solvate and deuterated compound thereof. The compound ...  
WO/2021/239885A1
The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and...  
WO/2021/233787A1
Compounds of the formula (I), wherein the substituents are as defined in claim 1. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controllin...  
WO/2021/233861A1
The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these comp...  
WO/2021/233786A1
Compounds of the Formula (I) wherein the substituents are as defined in claim 1. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling...  

Matches 1 - 50 out of 4,200