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Matches 1 - 50 out of 5,620

Document Document Title
WO/2021/071983A1
Described herein are agents that modify splicing of pre-mRNA and methods of making and using the same.  
WO/2021/071984A1
Described herein are agents that modify splicing of pre-mRNA and methods of making and using the same.  
WO/2021/071981A1
Described herein are agents that modify splicing of pre-mRNA and methods of making and using the same.  
WO/2021/060225A1
The present invention relates to compounds represented by formula (I) (in the formula, R1 represents, e.g., a substituted or unsubstituted C1-6 alkyl group, R2 represents a group represented by Ra-CO-O-CRb 2- or a group represented by Ra...  
WO/2021/050945A1
Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated b...  
WO/2021/050915A1
The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods ...  
WO/2021/049522A1
A compound represented by formula (I) or formula (II) has a pest control effect. (In the formulae, Q1 represents a pyrazine ring or the like; G1 represents a nitrogen atom or a carbon atom; X1 represents an alkyl group or the like; m rep...  
WO/2021/044437A1
The invention provides certain cocrystals of Olaparib and provides novel polymorphic forms of certain cocrystals of Olaparib. In particular, cocrystals of Olaparib with fumaric acid and 3,5-dihydroxybenzoic acid are described. The invent...  
WO/2021/009334A3
The present invention relates to herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The ...  
WO/2021/035257A1
The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (IA), formula (I), and formula...  
WO/2021/032161A1
Disclosed in the present invention are a halogen-substituted phenylate compound and applications thereof. Particularly provided are a compound shown in formula (I) or an optical isomer thereof, and pharmaceutically acceptable salts, prod...  
WO/2021/032033A1
The present invention belongs to the technical field of pesticides, and in particular relates to a pyridazinol compound, a derivative thereof, a preparation method therefor, a herbicidal composition and the use thereof. The pyridazinol c...  
WO/2021/032074A1
The present disclosure relates to a benzamide fused aromatic ring derivative, a preparation method therefor and an application thereof in medicine. Specifically, the present disclosure relates to a benzamide fused aromatic ring derivativ...  
WO/2021/020362A1
Provided is a compound which has a glucosylceramide synthase-inhibiting activity and is expected to be useful as a prophylactic or therapeutic agent for a lysosomal storage disease (e.g., Gaucher disease, Fabry disease, GM1-gangliosidosi...  
WO/2021/018834A1
The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, m, n and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use fo...  
WO/2021/009334A2
The present invention relates to herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The ...  
WO/2021/009335A1
The present invention relates to herbicidal substituted phenyl- pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The...  
WO/2021/004535A1
Compounds of Formula (I) or (Ia), pharmaceutically acceptable salts, stereoisomers, tautomers, solvates or prodrugs, and their use as HPK1 inhibitors are described herein, and also described are methods for preparing the compounds, and m...  
WO/2020/256636A1
In certain aspects, the invention provides a novel crystalline form of olaparib (4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fl uorophenyl]methyl(2H)phthalazin-1-one). In related aspects, the invention provides a processe fo...  
WO/2020/250223A1
The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents su...  
WO/2020/248065A1
The present application is directed to compounds of Formula (I), (II), (III) or (IV) compositions comprising these compounds, methods for their preparation and their uses, for example, as acyl hydrazone linkers, which can link two chemic...  
WO/2020/252414A1
Disclosed herein are naphthoquinone derivative compounds of the formula shown below, compositions thereof, and methods of using such compounds and compositions for treating or suppressing oxidative stress disorders and/or neurodegenerati...  
WO/2020/242245A1
The present invention relates to: a phthalazinone compound, or a racemate, stereoisomer, or pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of Sirt6-associated diseases, comprising, ...  
WO/2020/239076A1
Pyridazinone derivatives as thyroxine receptor-β agonists, and application thereof in preparing medicines for diseases related to thyroxine receptor-β agonists. Specifically disclosed is a compound represented by formula (I), or a phar...  
WO/2020/234715A1
The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): (I), wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention furth...  
WO/2020/228577A1
Provided are a pyridazinone derivative and the use thereof. By selecting specific modification groups of the pyridazinone derivative provided in the present invention having a structure as shown in formula (I), the results show that the ...  
WO/2020/228823A1
The present invention relates to novel amide compounds of formula (I), pharmaceutical compositions thereof, methods for preparing thereof, and uses thereof, wherein the symbols are as defined in the specification.  
WO/2020/221276A1
The present invention relates to a salt of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-dia mine and a solid form thereof, a method for preparing the solid form and a pharmaceutical composition comprising the solid form, as w...  
WO/2020/214999A1
The present disclosure relates to compounds for the use of treating neurodegenerative diseases and, in particular, to compounds targeting the Abelson non-tyrosine kinase (c-Abl) protein for such treatment. The neurological disorders and ...  
WO/2020/210626A1
Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2- (trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin- 7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprisi...  
WO/2020/198526A2
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associ...  
WO/2020/169042A1
Specifically, the present invention relates to the 6-oxo-1,6-dihydropyridazine prodrug derivative shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, a use thereof as a NaV...  
WO/2020/164970A1
The present invention relates to herbicidally active cinnolinium derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions...  
WO/2020/163541A1
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...  
WO/2020/163647A1
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...  
WO/2020/163375A1
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...  
WO/2020/051207A3
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/161248A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.  
WO/2020/160151A1
A compound having one of formula (1), formula (2), formula (3) and formula (4) or a pharmacologically acceptable salt thereof.  
WO/2020/156571A1
Provided is a pyridazine derivative as shown in formula (I), and a use thereof in preparing a drug for the prevention and/or treatment of indications related to HIF modulation. The pyridazine derivative is an ideal, highly-effective HIF-...  
WO/2020/159904A1
Compounds having the following formula (I): (Formula (I)) or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.  
WO/2020/157199A1
The present invention includes name compounds of general formula (I) : (I), in which R1, R2, R3 and A are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical ...  
WO/2020/140959A1
A 6-oxo-1,6-dihydropyridazine derivative, a preparation method therefor and medical use thereof, in particular, a 6-oxo-1,6-dihydropyridazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceuti...  
WO/2020/127168A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.  
WO/2020/127780A1
The present disclosure relates to heterocyclyl pyridazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.  
WO/2020/122092A1
The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I) [in the formula, each symbol is as described in the description] or a salt thereof has orexin ...  
WO/2020/115548A1
Combination therapies comprising administering radioimmunoconjugates and DNA damage response inhibitors.  
WO/2020/114869A1
The present invention relates to the use of herbicidal substituted phenyl-pyridazinediones and substituted phenyl-pyridazinone derivatives of formula (I), in combination with herbicidal pyrrolidinone derivatives of the formula (II) to co...  
WO/2020/109039A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description formula ...  
WO/2020/109391A1
The present disclosure relates to pyridazine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.  

Matches 1 - 50 out of 5,620