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Matches 1 - 50 out of 1,312

Document Document Title
WO/2018/037423A1
The present invention discloses a process for the preparation of pregnadiene derivatives having formula I, their stereoisomer and intermediate thereof. Formula I wherein each substituent is independently, R1 and R2 is hydrogen or C1 –C...  
WO/2017/192668A1
Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based o...  
WO/2017/153497A1
The invention provides a co-crystal, which co-crystal comprises beclomethasone dipropionate and a co-crystal former, which co-crystal former is adipic acid, maleic acid or isonicotinic acid. The invention also concerns a pharmaceutical c...  
WO/2017/150723A1
Algae that generates a sterol and a sterol production method that uses the algae. According to the present invention, a sterol is produced by culturing algae, such as strain AJ7867 (FERM BP-22304) and strains derived therefrom, that has ...  
WO/2017/106957A1
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.  
WO/2017/106957A8
This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.  
WO/2017/037081A1
The present invention relates to new compounds of formula (1) wherein R is -C(=O)CH2OH or -CH(OH)CH2OH; R1, is =O or OH; R2 is H or OH; R3 is H or C1-C4alkyl; R4 is H or C1C4alkyl. These compounds are obtained by a process using at least...  
WO/2016/123117A1
The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppre...  
WO/2016/120891A1
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alk...  
WO/2016/055533A1
The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, ...  
WO/2016/023082A1
H:\dar\Interwoven\NRPortbl\DCC\DAR\8230712_1.doc-12/08/2015 Abstract The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymp...  
WO/2015/180679A1
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as def...  
WO/2015/177469A1
The present invention relates to chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, the invention enables improvement of muscular quality in sarcopenic mammals ...  
WO/2015/121840A1
The present invention relates to a process for the synthesis of compounds of formula (I), (I) wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R' is dimethylam...  
WO/2015/089471A2
Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparat...  
WO/2015/089471A3
Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparat...  
WO/2015/063408A2
The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.  
WO/2015/063408A3
The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.  
WO/2014/115167A3
The present invention provides novel compounds of 11β-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitocho...  
WO/2014/091467A3
The invention relates to the compounds of formula I, formula II, formula III and formula IV or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical comp...  
WO/2013/135744A1
The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.  
WO/2013/122112A1
Provided is a prodrug of a therapeutically active organic compound having: an amino group, a cyclic amino group or a hydroxyl group in the molecule; and a 2-nitro-1-imidazole propionic acid. In particular, provided is a prodrug in which ...  
WO/2013/056181A1
Provided herein are 3,3-disubstituted 19-nor- steroidal compounds according to Formula (I) and (III): where R1,R2, R3, R3', R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful fo...  
WO/2013/002592A3
The present invention relates to a method for purifying high-purity betulonic acid, a method for preparing a piperazine betulonic acid amide derivative using high-purity betulonic acid and a derivative thereof, and a method for purifying...  
WO/2012/079279A1
The present invention relates to pregnane glycoside compounds containing orthoester groups, pharmaceutical compositions containing the compounds, and use thereof in the preparation of an immunosuppressant. More particularly, disclosed ar...  
WO/2011/150209A1
The present invention resides in the discovery that glucocorticoid receptor antagonists are effective for treating muscular dystrophy including type 1 or type 2 myotonic dystrophy. Treatment methods and kits are provided.  
WO/2011/130877A1
A crystalline form of methylprednisolone aceponate monohydrate exhibits an X-ray powder diffraction pattern having characteristic peaks at the diffraction angles 2θ= of 8.6°, 12.2°, 13.6°, 15.3°, and 19.3°. The method for preparing...  
WO/2011/087441A1
It is provided apharmaceutical composition comprising 3-beta-hydroxy-5-alpha- pregnan-20-one, at least one sterol or an ester thereof and a mixture of acylglycerols with a solid fat content of less than 25% at 25°C and 0% at 37°C.In ad...  
WO/2011/075701A4
Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxys...  
WO/2011/075701A3
Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxys...  
WO/2011/019821A2
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in...  
WO/2011/019821A3
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in...  
WO/2010/136940A1
This invention relates to novel glucocorticoid receptor agonists of formula (I) and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to th...  
WO/2010/062562A1
The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid pharmaceutical compositions for use in treating inflammation and other diseases and disorders.  
WO/2009/124300A2
The invention provides and describes solid state 17α-ethynyl-androst- 5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5- ene-3β,...  
WO/2009/044251A3
The present invention relates to hydrocortisone derivatives, the method of production thereof and the therapeutic or cosmetic use thereof to combat hair loss or in the treatment of cutaneous physiopathologies.  
WO/2009/032321A2
This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.  
WO/2009/032321A3
This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.  
WO/2009/022477A1
[PROBLEMS] To provide a polymer wherein a biologically active substance is distributed uniformly at a high density. [MEANS FOR SOLVING PROBLEMS] The problems can be solved by selecting and using polynorbornene as the polymer.  
WO/2009/019138A3
The present invention refers to an enzymatic process for obtaining 17alpha-monoesters of cortexolone and/or its 9, 11-dehydroderivatives starting from the corresponding 17alpha, 21-diesters which comprises an enzymatic alcoholysis reacti...  
WO/2009/019138A2
The present invention refers to an enzymatic process for obtaining 17alpha-monoesters of cortexolone and/or its 9, 11-dehydroderivatives starting from the corresponding 17alpha, 21-diesters which comprises an enzymatic alcoholysis reacti...  
WO/2008/097442A1
This disclosure relates to a composition comprising pregnane derivatives according to Formula (I), or a salt, solvate or hydrate thereof, and to a pharmaceutically acceptable carrier or excipient. The composition may be used to lower glu...  
WO/2008/067086A3
The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyper...  
WO/2008/012833A1
The present invention provides an improved process for the preparation of 16-dehydropregenolone acetate [16-DPA], wherein pseudodiosgenin diacetate (PDA) is oxidized to diosone by catalytic amount of KMnO4 in the presence of a co oxidant...  
WO/2007/026651A1
Disclosed is a novel therapeutic agent for hypertension. The therapeutic agent comprises a compound of the formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient.  
WO/2007/008155A1
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a P2X7 receptor antagonist, and a second active ingredient which is a corticosteroid, of use in the treatment of respirator...  
WO/2007/004236A3
The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rte of absorption has become a big challenge in day today life. Therefore anattempt has been made to pre...  
WO/2006/088134A1
It is intended to provide a method of relieving or avoiding a steroid-induced increase in ocular tension which is caused by the administration of a steroid compound. Namely, a steroid-induced increase in ocular tension can be relieved or...  
WO2005115332A3
The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time...  
WO/2006/041121A1
It is intended to provide: a remedy and/or a preventive for a chronic skin disease which comprises, as the active ingredients, (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a steroid dr...  

Matches 1 - 50 out of 1,312