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WO/2021/212787A1 |
An artificial bioprosthetic valve and a preparation method therefor. The artificial bioprosthetic valve comprises a support and a functional biological tissue material attached to the support. The functional biological tissue material is...
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WO/2021/182608A1 |
The purpose of the present invention is to provide: a coating agent that can be applied to various materials without using radiation; and a medical material using same. The present invention provides a coating agent containing a copolyme...
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WO/2021/164626A1 |
Disclosed are a functionalized biological matrix material, a preparation method therefor and use thereof, which belong to the technical field of medical materials. In the present invention, by means of the hybridization of a biological m...
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WO/2021/145330A1 |
Provided is a technology for realizing superior antithrombogenicity. This polyurethane or polyurethane urea has a graft chain having a specific structure. The two functional groups included in the specific structure may be the same or di...
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WO/2021/145362A1 |
The present invention provides a medical sheet which comprises nonwoven fabric formed of fibers containing aliphatic polyester, has a void ratio of 50-90%, and has cell infiltration-suppressing action. The sheet according to the presen...
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WO/2021/118205A1 |
The present invention relates to an implantable medical device capable of releasing an anti-inflammatory substance and, particularly, to an implantable medical device, which releases anti-inflammatory drugs while inserted in the body, so...
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WO/2021/107141A1 |
The present invention addresses the problem of providing a zwitterion compound that has excellent protein adsoprtion–suppressing action. A zwitterion compound that is a polymer that includes units represented by formula (1) (in which R...
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WO/2021/104835A1 |
A coating for a medical device is described. The coating comprises: a surface layer; and optionally a base layer; wherein the surface layer comprises a polymer chain attached to an anti-clotting group, wherein the anti-clotting group is ...
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WO/2021/106107A1 |
Disclosed are: an immunosuppressive cell-collecting material which includes a molded body having, as an aromatic substituent, a straight-chain aromatic polymer in which nonpolar side-chain amino acid residues are bonded at a ratio of 1-1...
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WO/2020/061067A9 |
The disclosure relates to compositions and methods of treating, improving, and accelerating the healing of large segmental bone defects in a subject. The method comprises administering to a patient in need of treatment an effective amoun...
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WO/2021/058835A1 |
The present disclosure relates to acidic sophorolipids and uses thereof, including for use in therapy and, in particular, in the treatment or prevention of cancer and associated pathologies.
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WO/2021/053996A1 |
[Problem] To provide a medical instrument that has excellent sliding properties (in particular, piercing characteristics) and is able to exert excellent antithrombogenicity. [Solution] This medical instrument comprises: a base material h...
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WO/2020/240446A1 |
A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to at...
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WO/2020/236139A1 |
Intraocular lenses with pressure sensors embedded therein, and methods of manufacture.
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WO/2020/218058A1 |
A tungsten wire (10) is one made from tungsten or a tungsten alloy, wherein the wire diameter D of the tungsten wire (10) is 100 μm or less and the number of twists to torsional rupture per 50 mm of the tungsten wire (10) is 250×exp(-0...
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WO/2020/213529A1 |
The present disclosure provides an antithrombogenic material having a substrate and a surface modified layer provided on at least a portion of the substrate, wherein: the surface modified layer includes a block copolymer having a first s...
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WO/2020/212978A1 |
There is provided herein a method of coating a polyurethane surface of an insertable medical device, the method comprising obtaining an insertable medical device or a part thereof comprising a polyurethane surface; performing a direct th...
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WO/2020/214836A1 |
The present invention pertains to methods of coating antimicrobial peptides on the biomaterial and the biomaterial coated thereby. The coating solution described herein comprises one or more antimicrobial peptides (AMPs) dissolved in a b...
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WO/2020/190214A1 |
Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the...
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WO/2020/181642A1 |
A preparation method for an ionic bond-covalent bond synergy-based surface heparinized anticoagulant medical device. In said method, firstly, a hydrophilic polymer of which the side chain is modified by a low molecular weight hyperbranch...
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WO/2020/158847A1 |
The purpose of the present invention is to provide a medical base material for an indwelling cardiovascular device, wherein a special knitted structure, which is formed of multifilaments containing ultrafine fibers, can maintain antithro...
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WO/2020/144244A1 |
The present disclosure relates to an anticoagulant-coated microporous hollow fiber membrane showing reduced thrombogenicity. The disclosure further relates to a method for producing the membrane and a filtration and/or diffusion device c...
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WO/2020/136665A1 |
Present invention discloses preparation of covalent conjugate Heparin – polymer using carboxyl group of Heparin sodium and terminal hydroxyl and/or group of amino group of polymer. This attachment is conducted for increasing the compat...
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WO/2020/130466A1 |
Disclosed is a blood-compatible polymer represented by formula 1. A polymer in which fluorinated methacrylate is grafted to a polyvinylidene fluoride copolymer, according to an aspect of the present invention, is a polymer with blood com...
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WO/2020/122193A1 |
Provided is a medical device having adequate mechanical characteristics and exceptional non-adsorptivity with respect to biological components. This medical device comprises a base material and a film formed on the surface of the base ma...
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WO/2020/108670A2 |
Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the...
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WO/2020/105570A1 |
The present invention pertains to an alloy for medical use that comprises Pt, Co, Cr, Ni and Mo. This alloy comprises 10-30 atm% inclusive of Pt, 20-31 atm% inclusive of Cr, 5-24 atm% inclusive of Ni, 4-8 atm% inclusive of Mo and the bal...
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WO/2020/070258A1 |
There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragment...
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WO/2020/045611A1 |
A goal of the present invention is to provide a cylindrical member for implantation that is capable of maintaining high patency through the achievement of antithrombotic properties, low swelling, and a low Young's modulus. The present in...
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WO/2020/039016A1 |
A vascular device (1) for insertion in a body lumen (7) comprises a surface (111), wherein at least a portion of the surface (111) is provided with double or more charged ions (112) such that the ions (112) are exposed to a bodily fluid ...
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WO/2019/203898A1 |
A method of manufacturing a medical product having an engineered heparin bioactive matrix for clinical application on a blood contacting surface comprises: a) activating a blood contacting surface of at least one component of a medical d...
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WO/2019/195607A1 |
A deployment system and method of use thereof is provided for an interior driveline that mitigates the risk of infections for a variety of implanted medical appliances with a percutaneous conduit. The interior driveline and driveline dep...
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WO/2019/195056A1 |
Described herein are cell compositions comprising a mesenchymal stem function cell (MSFC), e.g., an engineered MSFC or derivatives thereof, as well as compositions, pharmaceutical products, and implantable elements comprising an MSFC, an...
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WO/2019/187860A1 |
[Problem] To provide a medical appliance that has excellent sliding properties (piercing characteristics) and is able to exert excellent antithrombogenicity. [Solution] This medical appliance has, at the surface, a coating comprising a c...
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WO/2019/188598A1 |
[Problem] To provide a medical appliance that has excellent slipperiness (in particular, piercing characteristics) and is able to exert excellent anti-thrombogenicity. [Solution] This medical appliance has, at the surface, a patchy struc...
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WO/2019/170858A1 |
According to the invention there is provided inter aliaaprocess for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulan...
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WO/2019/170859A2 |
There is provided inter alia a solid object having a surface comprising a layered coating of cationic and anionic polymer, wherein the outer coating layer is a layer comprising cationic polymer to which is covalently bound an anticoagula...
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WO/2019/142710A1 |
Provided is a medical coating material with which it is possible to form a continuous coating without exposing the substrate surface, especially on silicone rubber substrates. The medical coating material according to the present inventi...
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WO/2019/138412A1 |
Compositions comprising electrospun fibers and pharmaceutical agents encapsulated thereto are provided. Further, articles such as medical devices and methods of use of said fibers, including, but not limited to coating of medical tubes, ...
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WO/2019/129640A1 |
A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resu...
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WO/2019/078056A1 |
Provided is a curable composition that makes it possible to obtain a cured product having excellent adhesion to substrates and excellent biocompatibility. Also provided are a film and a cured product having excellent adhesion to substrat...
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WO/2019/077929A1 |
Provided is a curable composition that makes it possible to obtain a cured product having excellent adhesion to substrates and excellent biocompatibility. Also provided are a film and a cured product having excellent adhesion to substrat...
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WO/2019/079535A1 |
Described herein is the use of a methylated/sulfated hyaluronan, sulfated hyaluronan, or the pharmaceutically acceptable salt or ester thereof for the treatment of chronic rhinosinusitis.
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WO/2019/074791A1 |
In this work, a hydrophilic, yet slippery solid surface was developed. Because the surfaces are hydrophilic, there is significant affinity between the surface and contacting water, which results in substantial spreading of the contacting...
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WO/2019/065947A1 |
The purpose of the present invention is to provide a medical material using a nickel titanium alloy which reduces the thickness of a polymer electrolyte while supporting an antithrombotic compound in an amount sufficient to create a ther...
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WO/2019/057709A1 |
The present invention relates i.a. to compositions which are suitable for treatment of infertility or subfertility, in particular infertility or subfertility caused by polycystic ovary syndrome (PCOS)or anovulation, or which are suitable...
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WO/2019/046853A1 |
The disclosure concerns medical devices configured to utilize nitric oxide (NO) donor materials to release NO gas upon contact with moisture in order to mitigate bacterial proliferation, coagulation, or a combination thereof, at a site o...
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WO/2019/042261A1 |
Disclosed in the present invention are a composite heparin anticoagulation coating liquid, microspheres for a coating, a preparation method, and applications. In the present invention, by means of combined use of curcumin and heparin, th...
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WO/2019/035365A1 |
Provided is an article, which is an antibacterial article, a cell culture article, an antithrombotic article, or a biomedical article, to which proteins, blood components, cells and bacteria tend not to adhere. The antibacterial article,...
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WO/2019/010490A1 |
Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.
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