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JP3577085B2 |
The present invention features an adduct protection assay involving the use of a labelled binding partner and a signal altering ligand. The signal altering ligand can preferentially alter the ability of label which is not part of a bindi...
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JP2004262875A |
To provide a method for synthesizing acridones simply and in a high yield capable of readily composing a library on acridones.The method comprises reacting halogenobenzoic acids represented by formula (1) (wherein X shows a halogen atom,...
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JP3566649B2 |
Tricyclic quinoline derivatives (I) are new. Tricyclic quinoline derivatives of formula (I) and their optical isomers, hydrates, solvates and acid-addition salts are new: R0 = H, OH or 1-6C alkoxy; R1, R2 = H, halogen, 1-6C alkyl, 1-6C a...
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JP2004524362A |
The present invention relates to a method for producing a cyclic pyridine base by reacting a cyclic ketone with an aliphatic aldehyde in the presence of ammonia in the gas phase in the presence of a catalyst. This method provides an envi...
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JP2004523946A |
In accordance with the present invention, nanometer-scale reversible electronic switches are provided that can be assembled to make cross-bar circuits that provide memory, logic, and communications functions. The electronic switches, or ...
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JP2004210763A |
To provide an ethylene compound, a structure and a method for producing a high density blue color laser-storage medium.This ethylene compound consists of an ethylene derivative having a chemical structure expressed by general formula (1)...
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JP2004521996A |
The present invention relates to squaraine dye containing terminal aminoanthracene or acridine groups and to a process for the preparation thereof.
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JP2004519516A |
A viologen-binding acridine-based bifunctional molecule or derivative thereof that can be used as a phototherapy agent and a catalytic photoactivated DNA cleavage agent, a method for producing the same, and a pharmaceutically acceptable ...
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JP2004517924A |
Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-...
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JP2004516243A |
The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
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JP2004515458A |
The present invention is directed to substituted thioacetamides of formula (I): in which Ar1, Ar2, R1-R4 and n are as defined in the claims, process for their preparation and uses of the thioacetamides for the treatment of sleepiness, ti...
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JP2004513117A |
Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2, R3, R4 and R5 are any of a number of groups as defined in the specification, A and D are as defined in the specification, and pha...
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JP2004510706A |
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is -O, L is -H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is...
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JP2004510764A |
The present invention concerns compounds of formula. In a preferable embodiment, X represents O; R1 represents C1-6alkyl; cycloC3-12alkyl or (cycloC3-12alkyl)C1-6alkyl, wherein one or more hydrogen atoms in a C1-6alkyl-moiety or in a cyc...
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JP2004509845A |
Novel "bispolyamine" inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...
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JP3512786B2 |
To provide an excellent improving agent for the excretory power of the bladder. This improving agent for the excretory power of the bladder consists of a non-carbamate-based amine compound having acetylcholinesterase inhibitory activity....
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JP2004507451A |
The present invention provides an anti-tumor chemotherapeutic to a patient having a tumor, the composition comprising; microspheres incorporating the anti-tumor chemotherapeutic; and, a suspending solution which surrounds the microsphere...
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JP3503403B2 |
To improve the luminous intensity, luminous efficiency, and stability in repeated use by reacting a dihalide of a specified divalent residue, a secondary amine derivative, potassium carbonate and a catalyst in a solvent. A dihalide of a ...
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JP2004051490A |
To provide a derivative of lucigenin having permeability through a biomembrane.The chemical luminescent compound having permeability through a biomembrane is represented by formula (1). A chemical luminescent reagent and a kit for measur...
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JP2004504382A |
The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
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JP2004504381A |
The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
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JP3463402B2 |
PURPOSE: To obtain a hole transport material excellent in the ability to transport holes. CONSTITUTION: A hole transport material represented by the formula (wherein R1 to R16 are each hydrogen, halogen, alkyl, alkoxy, thioalkoxy, cyano,...
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JP2003531908A |
The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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JP3454435B2 |
PURPOSE: To obtain the subject compound useful as an intermediate for synthesizing cerebral function disorder-improving medicines by reacting an aminonitrile derivative with a ketone derivative in the presence of a strong acidic ion exch...
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JP2003527230A |
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device compri...
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JP2003525274A |
The invention provides a compound of formula (I), wherein A, Ra, Rb, R1 to R5, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as alpha-2 antagonist. The compounds I can be used for the...
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JP3437244B2 |
PURPOSE: To provide a method for simultaneously detecting and/or determining at least two substances in a specimen. CONSTITUTION: In a specimen containing at least two substances, at least different two chemical luminescence compounds wh...
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JP2003523777A |
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device compri...
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JP2003523343A |
Compounds of formula (I): wherein 0<=n<=3, 0<=m<=6, R3 and R4 together form a phenyl ring, B represents a heteroaryl group, R1 and R2 represent a hydrogen atom or groups as defined in the description.
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JP2003519131A |
The present invention relates to substituted piperazine derivatives of general formula wherein Ra to Rc, Ya, Yb, X and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof,...
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JP2003515526A |
Compounds or their salts of general formula (I): A-B-N(O)2 wherein: A is a drug radical selected from ferulic acid and sulindac; B= -O-R1B-X-R2B-O- wherein R1B and R2B, equal to or different from each other, are linear or branched C1-C6 ...
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JP3373201B2 |
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JP2003012617A |
To provide an enamine compound which is an organic photoconductive material, having high electrification potential, high sensitivity, sufficient photoresponsivity at low temperature condition and rapid processing, excellent in durability...
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JP2003012618A |
To provide an enamine compound which is an organic photoconductive material, having high electrification potential, high sensitivity, sufficient photoresponsivity at low temperature condition and rapid processing, excellent in durability...
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JP2003012619A |
To provide an enamine compound which is an organic photoconductive material, having high sensitivity, sufficient photoresponsivity, excellent in durability, and an electrophotographic receptor and an image forming device using the same.T...
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JP2003012629A |
To provide an enamine compound which is an organic photoelectroconductive material having sufficient photoresponsivity in a high- speed process, excellent durability and usable for an electrophotographic photoreceptor, etc., the electrop...
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JP2002543171A |
Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
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JP2002543163A |
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are prov...
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JP2002543059A |
Compounds of formula (I) or (II), wherein X represents H, C1-6 alkyl or C1-6 alkoxy, said alkyl or alkoxy being optionally substituted with one or more groups; a is 0,1,2,3 or 4; Y represents H or C1-6 alkyl; 1, 2 or 3 of the members Z o...
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JP3357094B2 |
PURPOSE:To obtain a polymer having improved antifungal properties and resistance to the leaching of the antifungal component therefrom by polymerizing an ethylenically unsaturated monomer with a specified mono- to tri-functional antifung...
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JP2002541233A |
Compounds or their salts having general formula: A-B-C-NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.
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JP2002541236A |
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C...
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JP3338061B2 |
PCT No. PCT/NL97/00417 Sec. 371 Date Jan. 7, 1999 Sec. 102(e) Date Jan. 7, 1999 PCT Filed Jul. 15, 1997 PCT Pub. No. WO98/02421 PCT Pub. Date Jan. 22, 1998Dibenzodihydropyridinecarboxylic esters are provided which comply with formula (1)...
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JP2002302483A |
To obtain a derivative of lucigenin having permeability to a biomembrane.The compound is represented by formula (1) [wherein, R1 and R2 mean each independently a 1-12C alkyl group, a 2-6C alkenyl group, benzyl group, an aryl group or a h...
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JP2002534415A |
A compound of formula (I) wherein X1 is bond or -OCH2-; X2 is -(CH2)n-, in which n is 1, 2 or 3; X3 is bond, -O-, -S-, -OCH2-, or -NH-; R<1> is phenyl or pyridyl each of which may have one or two substituent(s) selected from the group co...
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JP2002532487A |
The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods....
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JP2002531396A |
The invention is in the field of cancer treatment. In particular, the present invention provides pharmaceutical compounds capable of interacting with mutant and non-mutant forms of cancer-related regulatory proteins such that the mutant ...
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JP2002530678A |
The present invention discloses a method for the measurement of hydride using a chemiluminescent compound, such as an acridinium compound. The source of hydride for the reduction of acridinium compound may be of chemical or biochemical o...
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JP3325370B2 |
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JP2002529533A |
The invention relates to 1-aminoethylquinoline derivatives, to pharmaceutical compositions containing them, to therapeutic methods of using them and to processes for preparing them.
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