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Matches 651 - 700 out of 5,296

Document Document Title
WO/2005/111027A1
A method of synthesising compounds of formula (I), wherein R1 and R2, which are the same or different, are each a branched or linear (C1-C8) alkoxy grouping or together form, with the carbon atom bearing them, a 1,3-dioxane, 1,3-dioxolan...  
WO/2005/110992A1
The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the ...  
WO/2005/111026A1
A method of synthesising compounds of formula (I), wherein R1 and R2, which are the same or different, are each a branched or linear (C1-C8) alkoxy grouping or together form, with the carbon atom bearing them, a 1,3-dioxane, 1,3-dioxolan...  
WO/2005/110984A1
A cyclic polycarboxylic anhydride, a polycarboxylic acid, or a mixture of these is reacted with hydroxylamine or a salt thereof in an organic solvent under dehydrating conditions to obtain the corresponding cyclic N-hydroxyimide compound...  
WO2005068643A3
The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having alpha,beta-enoate reductase activity towards molecule...  
WO/2005/108368A1
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzy...  
WO2004071460A3
The present application describes modulators of MCP-1 of formula (I): [chemical structure] or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asth...  
WO2005030794B1
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.  
WO/2005/097778A1
The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.  
WO/2005/097738A1
Disclosed are a compound represented by the formula (1) below, a prodrug thereof, and their pharmaceutically acceptable salts which have an effect of increasing LDL receptor expression and are useful as drugs for treating hyperlipemia, a...  
WO/2005/096709A2
A process for preparing 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide, compound of formula (I), said process comprising a. reacting compound of of formula (Ivb) with alkali metal methoxide to yield compound of formula (II); a...  
WO/2005/094835A1
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.  
WO/2005/094834A1
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.  
WO/2005/095338A1
The invention aims at providing novel compounds having regulatory effect on the activity of GPR (G protein-coupled receptor) 40 and being useful as insulin secretagogue or preventive or therapeutic agent for diabetes and so on. Compounds...  
WO/2005/092290A1
The invention relates to pharmaceutical compositions comprising 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide (also referred to as “licarbazepine”) as drug substance.  
WO2005066133A3
Novel process for preparation of 10-oxo-10, 11-dihydro-SH-dibenz[b,f] azepine-5­-carboxamide (oxcarbazepine) via intermediate 10-methoxy-5H­-dibenz [b,f] azepine -5 carbonyl, chloride; comprising the steps: a) Preparation of an interme...  
WO/2005/092862A1
Process for preparing oxcarbazepine according to Scheme 1: characterized by the use of triphosgene as chlorocarbonylating agent in step a).  
WO2005042697A3
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.  
WO/2005/087746A1
The present invention relates to novel benzazepine derivatives of formula (I); wherein: R1 represents -C3-7 cycloalkyl optionally substituted by C1-3 alkyl; R2 represents -aryl, -heterocyclyl, heteroaryl, -aryl-X-C3-8 cycloalkyl, -aryl-X...  
WO/2005/085183A1
The invention relates to a method of preparing benzazepine compounds having general formula (IA) consisting in reacting at least one compound having general formula (IIA) with an olefin, the compound thus obtained then being cyclised suc...  
WO2005053702A3
The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof; ...  
WO2004093796A3
Lactam derivatives of the general formula (I), are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.  
WO/2005/082859A1
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, dep...  
WO/2005/077907A1
The invention concerns novel tetrahydrobenzo[d]azepin-2-one derivatives, a method for the production thereof, their use for treating and/or preventing diseases, and their use for producing medicaments for treating and/or preventing disea...  
WO/2005/077908A1
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...  
WO/2005/077921A1
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...  
WO2005030794A3
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.  
WO2004060376A8
The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibitin...  
WO/2005/073196A1
A compound of the following formula (I). This compound (I) can be produced by reacting a 1,1'-binaphthyl 2,2'-dimethylenebromide derivative which can be produced through a relatively small number of steps with an easily available seconda...  
WO/2005/070877A1
The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these...  
WO/2005/070887A1
A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts formula (I) wherein A is CHR9, wherein R9 is H, C1-C6 alkyl;n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S...  
WO2005019179A3
The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of , for example, central nervous system disor...  
WO/2005/068643A2
The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having &agr ,β-enoate reductase activity towards molecules ...  
WO2005037795A3
The invention is directed to nonpeptide substituted benzazepines of Formula (I), which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased...  
WO/2005/066159A1
The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR1R2, O, S, -SO2, C=0 or NR9; Z is CR1R2, O, S, -SO2, C=O or NR9 and each G is independently a CR1...  
WO/2005/066123A1
This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (I). Each variable is defined in the specification.  
WO/2005/066133A2
Novel process for preparation of 10-oxo-10, 11-dihydro-SH-dibenz[b,f] azepine-5­-carboxamide (oxcarbazepine) via intermediate 10-methoxy-5H­-dibenz [b,f] azepine -5 carbonyl, chloride; comprising the steps: a) Preparation of an interme...  
WO/2005/066134A1
Dicarboxylic acid salts of compounds of the formula (II) wherein R represents a selectively removable protecting group; and (S) denotes the (S)-configuration of the asymmetric carbon atoms, which are useful as intermediates for the prepa...  
WO2005037785A3
The invention relates to compounds having general formula (I), wherein: n represents the number 1 or 3; R1 represents either H or a cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl group; X represents either H or one or more su...  
WO2004089890A3
Disclosed is a new process and intermediates for preparing benzazepines of Formula wherein R<1> and R<2> are as defined herein.  
WO/2005/058837A1
The present invention relates to novel benzazepine derivatives of structure (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psych...  
WO2005035504A3
The present invention provides compounds of formula (I), which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprisi...  
WO/2005/058328A1
The invention relates to tetrahydrobenzazepines of the general formula (I) in which the variables Ar, A, B, Y, R1 and R2 have the meanings indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated ac...  
WO/2005/056546A1
The invention relates to novel keto lactam compounds, hydrogenated derivatives and tautomers thereof. These compounds have valuable therapeutic properties and are particularly suited for treating diseases that respond to the modulation o...  
WO1990000853A8
Methods and compositions are disclosed for treating drug dependence, movement disorder and stereotypic behavior with certain fused benzazepine compounds.  
WO/2005/053702A2
The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof; ...  
WO/2005/054190A1
This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I), wherein m is an integer from 1 to 3; X is methylene, oxygen, sulphur or a NR6 group; R1 is a straight or...  
WO/2005/051916A1
The present invention relates to novel salts of 7-[4-(4-chlorobenzyloxy)benzenesulfonyl]-8-methoxy-3-methyl- 2,3,4,5-tetrahydro-1H-3-benzazepine and a pharmaceutically acceptable solvate thereof, pharmaceutical formulations, processes fo...  
WO/2005/051399A1
This invention provides one or more chemical entities selected from a compound of formula (I) and a pharmaceutically acceptable salt and solvate thereof. The compounds of formula (I) and pharmaceutically acceptable salts or solvates ther...  
WO/2005/051397A1
The invention provides one or more chemical entities selected from a compound of formula (I): (I) wherein R1 represents C1-6alkyl, trifluoromethoxy or halo; R2 represents hydrogen, C1-6alkyl or halo; or when R1 and R2 are positioned at t...  

Matches 651 - 700 out of 5,296