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WO2008006295B1 |
(-) or (+) Isomer compounds of formula (I) and pharmacological salt, in which R1 represents H or halo, R2 represents CF3, CN or halo, R3 represents C1-6 linear or branched alkyl, C3-6 cycloalkyl. A process for preparing said compounds an...
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WO/2008/022062A1 |
Alkylammonium halides of the formula are described wherein the alkylammonium halide is prepared by reacting an alkylamine hydrohalide salt and its corresponding free amine with at least two equivalents of an epihalohydrin.
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WO/2008/018148A1 |
It relates to a process for producing an amino compound in which by reacting a polyhydric alcohol or an amino alcohol with ammonia or a primary amine or a secondary amine, a corresponding tertiary amine, amino alcohol or the like is prod...
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WO/2008/015584A2 |
The invention relates generally to an improved process for manufacturing desvenlafaxine free base and salts or solvates thereof.
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WO/2008/015689A1 |
A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate...
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WO/2008/013993A2 |
The present invention describes processes for the preparation of O-desmethylvenlafaxine and the intermediates cyclohexylbenzylcyanide and tridesmethylvenlafaxine, which may be used as intermediates in preparing O- desmethylvenlafaxine.
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WO/2008/012283A1 |
The present invention relates to an improved process for the preparation of (2R,3R)-3- (3-methoxyphenyl)-N,N,2-trimethylpentanamine which is an intermediate for the preparation of the analgesic tapentadol.
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WO/2008/013990A2 |
Provided are processes and intermediates for the synthesis of O- desmethylvenlafaxine.
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WO/2008/011791A1 |
The present invention provides crystalline tetrabenzyl voglibose with the following physical properties: there are peaks at 2θ=16.84±0.20°C, 18.99±0.20°and 24.11±0.20°of its Cu X-ray powder diffraction spectrum, and its melting po...
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WO/2008/012046A1 |
The present invention relates to an improved process for the preparation of 3- [(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
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WO/2008/013995A2 |
The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
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WO/2008/012047A1 |
The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
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WO/2008/006864A1 |
The invention relates to a method for producing optically active amines, which comprise an amino group at the chiral center and at least one further amino group, and/or at least one hydroxyl group, by means of optical cleavage of the res...
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WO/2008/006749A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006754A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006750A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006752A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/005358A2 |
Described are antioxidant macromolecules and methods of making and using same.
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WO/2008/000696A1 |
The invention relates to amino(meth)acrylates obtained from the reaction of amines with a mixture of epoxy(meth)acrylates and (meth)acrylated diluent and there use for making flexible varnishes, coatings, adhesives and inks.
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WO/2007/147866A1 |
The present invention generally relates to a process for preparing alkoxylated alkylamines and/or alkyl ether amines. The process consists of two stages and utilizes a catalyst with a multiple-charge counterion. The alkoxylated alkylamin...
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WO/2007/147547A1 |
A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3- phenylpropylamiηes from cinamoyl chloride via N-alky-3-phenylprop-2-en-1 -amine has been developed.
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WO/2007/145203A1 |
It is intended to provide a method for producing a compound useful as a production intermediate of a pharmaceutical represented by the following general formula (I): (I) ((R)n represents the same or different halogen atoms in number of (...
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WO/2007/146145A1 |
Industrial processes for the alternating conversion of glycerol to either an amino alcohol product or propylene glycol are disclosed. Glycerol is converted to hydroxyacetone which may then be directly reduced to obtain propylene glycol o...
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WO/2007/144091A1 |
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, ch...
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WO/2007/146143A2 |
Processes for converting glycerol to an amino alcohol product involving reacting glycerol with a metal catalyst to obtain hydroxyacetone, and reacting the hydroxyacetone with an amine compound to obtain an adduct that is then reduced usi...
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WO/2007/146144A1 |
Processes for the conversion of glycerol to a product mixture of an amino alcohol product and propylene glycol are disclosed. Glycerol is converted to hydroxyacetone and the hydroxyacetone is reduced with a reducing agent or reacted with...
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WO/2007/140965A1 |
This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof , comprising the following steps: a)...
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WO/2007/141593A2 |
The invention relates to an improved process for preparing metoprolol and its salts.
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WO/2007/140986A1 |
The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. Thi...
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WO/2007/140611A1 |
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are partic...
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WO/2007/138440A1 |
The invention provides a process for the production of a compound of formula (I), wherein Y is selected from CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX is hydroxy or O...
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WO/2007/137799A1 |
The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-l-phenylpropyl)-4-(hydroxymethyl) phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formul...
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WO/2007/135179A1 |
Ligands of the formula (I) secondary phosphine-Q-P(=O)HR1 (I) in the form of mixtures of diastereomers or pure diastereomers, in which secondary phosphine is a secondary phosphine group with hydrocarbon radicals or heterohydrocarbon radi...
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WO/2007/136323A1 |
The present invention relates to a process for the production of a compound of formula (I) comprising a reduction of the carboxyl and cyanide groups of a compound of formula (III), followed by resolvation of the racemic product into the ...
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WO/2007/128463A1 |
The present invention relates to a process for the deprotection of protected amine compounds, wherein the protected amine compound is contacted with an electrophilic oxidating agent that is optionally formed in situ, said electrophilic o...
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WO/2007/130704A1 |
The process of the present invention can be briefly summarized as depicted in the following scheme: R1is C1-Calkyl, R2 is C1-C6alkyl and Hal is a halogen atom.
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WO/2007/127108A1 |
A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazen...
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WO/2007/122579A2 |
A process for the preparation of 4-hydroxyalkylamino-2-nitro-anisoles of the general formula (I) wherein m is 2 or 3; by reaction of a 4-halogeno-3-nitro-aniline of formula (II) with a chloroalkyl-chloroformate, alkaline ring closure of ...
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WO/2007/122488A2 |
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in pa...
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WO/2007/120925A2 |
Methods for preparing crystalline forms of O-desmethylvenlafaxine a described.
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WO2006097421A9 |
The present invention relates to a method of removing SO2 contaminants from dimethyl sulfate (DMS) by treatment with an oxidizing agent, and to a process for the preparation of odour free fatty acid trialkanolamine esters quaternized wit...
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WO/2007/110548A1 |
The invention relates to a process of diastereoselective synthesis. This process carries out the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below, in which: R repr...
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WO/2007/112358A1 |
The present invention provides a method for the synthesis of ß2-amino acids. The method also provides methods yielding a-substituted ß-amino aldehydes and ß-substituted γ-amino alcohols. The present method according to this invention...
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WO/2007/107557A1 |
A process for preparing N,N-dimethylaminoethoxyethanol (DMAEE), wherein a) dimethylamine and ethylene oxide are reacted, b) the resulting product mixture is separated by distillation from N,N-dimethylethanol-amine and DMAEE to obtain a D...
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WO/2007/101527A1 |
A personal care composition is provided which includes a trihydroxy and quaternary ammonium substituted dipropyl ether. The substituted dipropyl ether functions as a humectant when applied to skin to moisturize both in high and low relat...
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WO/2007/101872A1 |
The present invention relates to a process for the enantiomeric enrichment of salbutamol and salbutamol precursors and the acid-addition salts thereof: (I) where R is hydrogen or benzyl, R' is hydrogen or benzyl and X is CH2OH or COO-C1-...
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WO/2007/099894A1 |
An object is to provide a method for production of an industrially useful amine derivative safely and with high efficiency by employing a deprotecting technique which is applicable to any protected amine derivative for general purposes. ...
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WO/2007/098029A1 |
Processes for preparing amino alcohols or salts thereof and sulfonamide substituted alcohol compounds are provided. Desirably, the sulfonamide substituted alcohol compounds are heterocyclic sulfonamide trifluoroalkyl-substituted alcohol ...
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WO/2007/094806A1 |
Compositions and methods for making compositions including a quaternary trialkylammonium halide compound are described. Compositions follow the formula (I): wherein the R1 groups are each individually selected from alkyl groups having fr...
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WO/2007/093514A1 |
The invention relates to a method for producing ethylene amines and ethanol amines by the hydrogenating amination of monoethylene glycol and ammonia in the presence of a catalyst. Said method is characterised in that it takes place in tw...
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