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WO/2013/067679A1 |
A method for preparing polymethylene polyphenyl polyamino formate is provided, which is carried through the condensation of phenylaminoformate with methylating reagent under the catalyzation of phase-transfer acidic catalyst. The method ...
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WO/2013/070118A1 |
This invention relates to novel substituted 4,5-diamino-3-alkyloxy- cyclohex-1-ene carboxylic acids, esters thereof or pharmaceutically acceptable salts and/or hydrates, to novel antiviral medicines - inhibitors of the activity of neuram...
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WO/2013/065825A1 |
Provided is a cationic lipid expressed in the following formula (I), which facilitates introduction of a nucleic acid into a cell, a composition containing the cationic lipid and the nucleic acid, a method for introducing the nucleic aci...
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WO/2013/067163A1 |
In one aspect, the invention relates to compounds having the formula: (I) where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. I...
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WO/2013/060950A1 |
The invention relates to a method for preparing a compound comprising at least one β-hydroxy-urethane unit and/or at least one γ-hydroxy-urethane unit, consisting in reacting a compound (A) comprising at least one cyclocarbonate reacti...
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WO/2013/062028A1 |
Provided are a novel compound having an antiviral effect, particularly HIV replication-inhibiting activity, and a medical drug, particularly an anti-HIV drug, containing the same. The compound is represented by Formula (I) (where the bro...
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WO/2013/062024A1 |
Provided is a plant disease control agent which, regardless of where employed, effectively controls a wide range of plant pathogens. This plant disease control agent contains, as an active component, a compound represented by formula (I)...
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WO/2013/060097A1 |
The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereof, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment ...
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WO/2013/057439A2 |
The invention relates to a polyurethane resin composition which comprises a pre-polymer and a polymer plasticiser and which can also comprise at least one component selected from the group containing: a masked polyisocyanate, a diluent p...
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WO/2013/057430A1 |
The invention relates to polyurethane resin compositions and, in particular, stable, ready-to-use polyurethane resin compositions comprising: a masked polyisocyanate having formula (I), wherein B represents alkyl and A represents a group...
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WO/2013/057429A2 |
The present invention relates to a polymerisable plasticiser formed by a hydrocarbon chain, one end of which bears more than one isocyanate function, said hydrocarbon chain comprising and/or being substituted by an aromatic ring and/or a...
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WO/2013/053940A1 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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WO/2013/053941A1 |
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...
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WO/2013/055572A1 |
Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions ...
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WO/2013/038603A1 |
A polymerizable monomer which, when used in a dental material, can increase the mechanical strength of the dental material and can impart good handleability to the dental material is an adamantane derivative represented by formula (1). (...
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WO/2013/036674A1 |
The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R5 are as defined and described herein, compositions thereof, and methods of using the same.
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WO/2013/030193A1 |
The present invention relates to γ,δ-unsaturated a-amino acids of general formula (I). The present invention also provides a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reacti...
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WO/2013/028543A1 |
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically ef...
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WO/2013/024383A1 |
The present invention relates to an improved process for the preparation of Lacosamide having formula (I).
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WO/2013/022047A1 |
The present invention provides a compound which has an inhibitory activity on lysine-specific demethylase 1 and is useful as a medicinal agent such as a prophylactic or therapeutic agent for cancer and central nervous system diseases. Th...
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WO/2013/016807A1 |
The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient insulin secretion such as diabetes and metabolic syndrome in a subject in need...
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WO/2013/014191A1 |
It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it ...
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WO/2013/014354A1 |
The invention relates to ceramide-analogue compounds which have a cyclic structure derived from cyclopropane, from cyclobutane or from cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is link...
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WO/2013/012814A2 |
The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst.
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WO/2013/011526A1 |
An improved, efficient, safe and convenient process for preparation of lisdexamphetamine and its pharmaceutically acceptable salts by using novel mixed anhydride intermediate is provided. A process for preparation of diamino protected am...
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WO/2012/171941A1 |
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radio labelled amino acids for use in in vivo imaging...
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WO/2012/171114A1 |
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic...
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WO/2012/165650A1 |
A new method for manufacturing an isoxazoline compound represented in formula (9) (in the formula, R1 represents a C1-C12 alkyl group optionally having one or more halogen atoms, or a C3-C12 cycloalkyl group optionally having one or more...
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WO/2012/163815A1 |
The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.
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WO/2012/166665A2 |
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutatio...
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WO/2012/165651A1 |
A new method for manufacturing a benzylamine compound represented in formula (7) (in the formula, R2 represents a C1-C6 alkyl group optionally having one or more halogen atoms, or a halogen atom, R3 represents a halogen atom or a hydroge...
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WO/2012/164055A2 |
The present invention relates to a compound of formula (I), or pharmaceutically acceptable, stereoisomers, salts or solvates thereof to methods for its synthesis, and use in the treatment of pain and to a method of treatment of pain usin...
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WO/2012/165546A1 |
The present invention provides a method that is for producing a peptide and that contains the following step (1): (1) a step for eliminating, by means of an organic base that is not nucleophilic in an ether-based solvent or a halogen-bas...
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WO/2012/165268A1 |
A process for producing an ester compound (1) or a salt thereof, comprising steps A to G as mentioned below. The process enables the production of the ester compound (1) or the salt thereof which is useful as an intermediate for the prod...
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WO/2012/157566A1 |
The purpose of the present invention is to provide a dental material which has little polymerization shrinkage especially during the curing process and which can be inexpensively produced even on an industrial scale. Another purpose of t...
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WO/2012/157568A1 |
The purpose of the present invention is to provide a novel compound which has little polymerization shrinkage especially during the curing process and which can be inexpensively produced even on an industrial scale. Another purpose of th...
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WO/2012/155834A1 |
The present invention provides a preparation method for N-methyl-N-ethyl-carbamic acid 3-[(S)-1(dimethylamino)ethyl] phenyl ester (as represented by the compound in formula X). The present invention also provides the following intermedia...
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WO/2012/150220A1 |
This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds...
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WO/2012/147897A1 |
With the method for producing an amine compound (5) according to the present invention, that includes the following steps, it is possible to produce an amine compound regardless of the presence of inorganic salts. Step (1), a step in whi...
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WO/2012/136121A1 |
An amino phenylpropanoid compound, or a geometric isomer thereof, or a pharmaceutically acceptable salt or hydrate thereof as represented by Formula I, a preparation method therefor, and a pharmaceutical composition containing the compou...
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WO/2012/133737A1 |
Provided are: a novel crosslinkable amine compound for producing a polymer membrane for separating carbon dioxide from another gas with high selectivity; a polymer membrane using the compound; a method for producing the polymer membrane;...
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WO/2012/131699A1 |
The invention discloses a novel process for preparation of highly pure 3-dimethylaminophenyl dimethylcarbamate via formation of aryl dimethylcarbamate which can be easily obtained from diaryl carbonate and dimethylamine.
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WO/2012/126797A2 |
The invention relates to the use of oligomeric carbodiimides containing at least one heterocyclic end group as stabilizers for polymers. The oligomeric carbodiimides can be compounds of the general formula (I), in which A1, A2 are identi...
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WO/2012/121248A1 |
A method for highly enantio-selectively producing an optically active spirolactone compound using a iodoarene derivative which can be easily synthesized and scarcely racemized. From 2,6-dihydroxyiodoarene, a flexibly designable hypervale...
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WO/2012/121079A1 |
Provided is a compound represented by general formula (1). Also provided is a method for producing a compound represented by formula (1) that comprises a reaction step for reacting a compound represented by general formula (2), a compoun...
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WO/2012/115110A1 |
[Problem] To provide a process for efficiently producing carbonyl compounds, particularly, a process for efficiently producing N-substituted carbamic acid esters. [Solution] This process for producing carbonyl compounds includes a step (...
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WO/2012/111946A2 |
The present invention relates to a method for preparing solid carbamic acid derivative powder which comprises a step of reacting liquid amine derivatives with carbon dioxides at -30 to 500 ℃ under 0.3 to 100 MPa. In addition, the inven...
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WO/2012/112304A1 |
Addition-fragmentation agents of the formula are disclosed formula (I): wherein R1, R2 and R3 are each independently Z-Q-, a (hetero)alkyl group or a (hetero)aryl group with the proviso that at least one of R1, R2 and R3 is Zm-Q-, Q is a...
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WO/2012/105321A1 |
Provided is a photoresist composition which contains a polymer compound that contains, as a constituent unit, a specific methacrylic acid ester derivative. The photoresist composition is capable of forming a photoresist pattern that has ...
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WO/2012/098075A1 |
This invention relates to a novel chemical process for the synthesis of 2-ethyoxycarbonylamino-5-(4-fluorobenzylamino)-nitrobenzene and its use in the preparation of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene
(retigabi...
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