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JPH0776214B2 |
Novel benzoheterocyclic compounds of formula (I), wherein R<1> is H, halogen, alkyl, optionally substituted amino, alkoxy; R<2> is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally su...
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JPH07188076A |
PURPOSE: To provide a two-stage method for providing a reaction mixture having a significantly increased content of 3-fluoro-4,6-dichlorotoluene. CONSTITUTION: A method for producing 3-fluoro-4,6-dichlorotoluene with reduced formation of...
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JPH0742277B2 |
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JPH07501054A |
PCT No. PCT/US92/08103 Sec. 371 Date Mar. 3, 1994 Sec. 102(e) Date Mar. 3, 1994 PCT Filed Sep. 28, 1992 PCT Pub. No. WO93/09104 PCT Pub. Date May 13, 1993.The present invention provides substituted dibenzoxazepine compounds of Formula I:...
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JPH07500602A |
The present invention provides substituted dibenzoxazepine compounds of Formula I: which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of...
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JPH06510748A |
The present invention provides substituted dibenzoxazepine compounds of Formula I: which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of...
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JPH0675176B2 |
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JPH0667914B2 |
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JPH0662670B2 |
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JPH06172345A |
PURPOSE: To obtain the subject compound useful as an antimicrobial agent in high yield and high purity by cyclizing an acrylic acid derivative in the presence of a basic catalyst and then hydrolyzing the cyclized compound. CONSTITUTION: ...
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JPH0643390B2 |
An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an exter...
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JPH06157481A |
PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin. CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the ...
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JPH0656807A |
PURPOSE: To provide a new compd. which is effective to treat, prevent or control renin-associated hypertension, hyperaldosteronism, congestive heart failure and galucoma. CONSTITUTION: This compd., for example a compd. expressed by formu...
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JPH064604B2 |
Compounds of formula (I):or a salt thereof, in whichW is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group,R' is hydrogen or methyl,R2 is carboxyl or a group O-Z-CO2H or an ester or amide thereof; a ...
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JPH0579671B2 |
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JPH0568468B2 |
Novel condensed, seven-membered ring compounds of the formula [wherein R<1> and R<2> are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R<3> is hydrogen, option...
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JPH05506426A |
There are provided novel chelating agents useful in the preparation of contrast media for diagnostic imaging or of radiotherapeutic or detoxification compositions.
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JPH05222005A |
PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronis...
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JPH05222013A |
PURPOSE: To provide the subject macrocyclic lactam derivative having a inhibiting action against neutral endopeptidase, which is useful for treating cardiac vascular diseases. CONSTITUTION: The compound is expressed by formula I [R is H ...
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JPH0545595B2 |
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula wherein R and R1 are independently selected from hydrogen, lower alkyl or alkoxyalkyl groups; R2 is lower alkyl, aryl, or hetaryl; ...
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JPH05163245A |
PURPOSE: To obtain a new dibenzazepine derivative extremely useful as a therapeutic agent for various allergic diseases and bronchial asthma because of its having excellent antihistamine action and antiallergic action and yet no exhibiti...
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JPH05140128A |
PURPOSE: To obtain new monomeric and polymeric compds. useful as antimicrobial agents having low toxicity to a plant used for controlling plant pathogenic microorganisms, especially plant pathogens belonging to Xanthomonas Dowson. CONSTI...
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JPH05503091A |
Novel benzoxazine compounds of the structure (I) wherein X and Y are independently selected from the group hydrogen, alkyl, alkoxyalkyl, aminoalkyl, hydroxyalkyl and hydroxyaminoalkyl, each alkyl moiety having 1 to 6 carbons, and m=1, 2 ...
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JPH0534396B2 |
The present invention relates to a detergent composition in aqueous solution comprising, (i) a surfactant selected from anionic, nonionic, zwitterionic and cationic surfactants and mixtures thereof, (ii) a precursor compound capable of g...
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JPH0565257A |
PURPOSE: To obtain a new polycyclic compound useful as an antihistamine agent and an antiallergic agent having low side action and excellent selectivity. CONSTITUTION: A polycyclic compound shown by the formula A-COCH3 [A is group shown ...
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JPH051261B2 |
Novel 1,4-di(substituted amino)-5,8-dihydroxyanthraquinones wherein the substituents are alkylamino alcohol and/or alkyl cyclicamide and their pharmacologically acceptable acid-addition salts useful as antitumor and chelating agents are ...
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JPH0481593B2 |
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JPH04288064A |
PURPOSE: To provide a novel compd. which has antihyperalgesic and is useful for the treatment of the pains of an inflammation state, rheumatoid arrthritis, osteoarithritis, etc. CONSTITUTION: This compd. is expressed by formula I (X is o...
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JPH04234862A |
PURPOSE: To provide a novel method for industrially producing 3methoxy-11- methylbenz[b,f][1,4]oxazepine-8-benzoic acid. CONSTITUTION: 3-Acetoxyamino-4-(3-methoxyphenoxy)benzoic acid is subjected to a ring-closing reaction in a liquid de...
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JPH04217961A |
PURPOSE: To provide new compounds which inhibit the angiotensinogen-cutting action of the natural proteolytic enzyme, renin. CONSTITUTION: This compound is represented by formula I [A is H, Het (Het is 5-7 membered monocyclic ring having...
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JPH04211071A |
PURPOSE: To obtain a new polycyclic compound useful as an antihistaminic agent, a hypnotic agent, a sedative, an analgesic agent, a hyperkinetic agent for gastrointestinal tract movement, etc., excellent in selectivity with hardly any si...
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JPH04178336A |
PURPOSE: To treat spinal injury by administering an effective amount of a serotonin antagonist to mammal. CONSTITUTION: Spinal injury is treated by administering an effective amount of serotonin antagonist, preferably 5HT1 A antagonist, ...
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JPH0433795B2 |
New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I I wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hydrogen atom, n i...
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JPH044313B2 |
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JPH041196A |
NEW MATERIAL: A spiro-oxazepin-oxazine compound of formula I (X is N, CH; R is H, a 1-5C alkyl optionally-substituted by 1-5 halogens, 1-5C alkoxy, 1-5C carboxyalkyl, CN, 2-5C alkenyl, phenyl, benzyl; R1-R12 are each H, a 1-5C alkyl 2-5C...
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JPH03275677A |
NEW MATERIAL:A compound expressed by formula I [R1 is 1-5C (allyl group substituted) alkyl; R2 is H, 1-5C alkyl or protected 1-5C hydroxyalkyl; R3 and R4 are R2 or 1-5C (allyl group substituted) alkoxy; A is 2-5C (substituted) alkylene; ...
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JPH03258773A |
PURPOSE: To obtain the subject compound useful as medicaments, by reacting a primary amine, a diol and hydrogen in the presence of a specific catalyst and a catalytic amount of a basic alkali metal or alkaline earth metal compound at hig...
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JPH03251574A |
NEW MATERIAL:A compound of formula I [R1 is 1-5C alkyl or 1-5C allylsubstituted alkoxy; R2 is H, 1-5C alkyl, protected 1-5C hydroxyalkyl or protected carboxyl; R3 is R1, H, protected 1-5C hydroxyalkyl or 1-5C alkoxy; A is (substituted) 2...
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JPH03246284A |
NEW MATERIAL:The compound of formula I {R1 and R2 are H or alkyl; R3 is H, alkyl or (substituted) phenylalkyl; R4 and R5 are H, halogen, alkyl, alkoxy, amino, etc.; X is NH; R6 is group of formula II (m is 0 or 1), formula III [R7 is alk...
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JPH03246266A |
PURPOSE: To safely obtain the subject compound useful as an intermediate for pharmaceuticals at a low cost by using 3-methoxyphenol and 4-chloro-3- nitrobenzoic acid as raw materials and subjecting the compounds to diphenyl etherificatio...
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JPH0366311B2 |
This invention relates to a compound of the formula (I) wherein R1, R2, R3, and R4, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl or alkoxy group of from 1 to 6 carbon atoms; R5 and R6, which m...
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JPH0359065B2 |
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JPH0359067B2 |
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JPH0359068B2 |
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JPH0359066B2 |
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JPH0354937B2 |
NEW MATERIAL:A compound shown by formula I (R is H, alkoxycarbonyl, alkyl or alkenyl; R1 is H, halogen, OH, SH or alkoxy; R2 is H, halogen or alkyl; R3 is H, halogen or alkoxy; R4 is H, halogen, OH or CN; R5 is H, halo gen, OH or alkoxy;...
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JPH0354085B2 |
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JPH03184963A |
NEW MATERIAL:The dibenzoxazepine derivative of formula I (R is H or lower alkyl; n is 1-5) and its salt. EXAMPLE: 4-(2-Chlorodibenz[b,f][1,4]oxazepin-11-yl)-1-piperazinepropi
onic acid ethyl ester. USE: It has antidepressant, antianxiety...
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JPH03178951A |
PURPOSE: To obtain benzazepine intermediates containing a new optically active compound in a high yield, by reacting a nitrotoluene with a benzylidene malonate or an optically active 1,4-oxazepin-dione using a fluoride ion source as a ca...
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JPH03170053A |
PURPOSE: To quantitatively predict the conformity by minimizing the species energy of molecule as the function of two surface angle of the molecule while holding the length and angle of the bond constant, and uniformly mapping subspace. ...
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