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Matches 351 - 400 out of 11,735

Document Document Title
WO/2010/132839A3
The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.  
WO/2010/132768A1
Antibacterial compounds of structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use o...  
WO/2010/132760A9
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined here...  
WO/2010/132768A9
Antibacterial compounds of structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use o...  
WO/2010/132759A1
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 or R3 are as defined herei...  
WO/2010/132839A9
The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.  
WO/2010/132765A3
Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with prepara...  
WO/2010/132839A2
The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.  
WO/2010/132759A9
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 or R3 are as defined herei...  
WO/2010/132777A2
A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.  
WO/2010/132760A1
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined here...  
WO/2010/132765A9
Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with prepara...  
WO/2010/126435A1
The present invention relates to novel compounds having an effect as i.a. galectin inhibitors, to the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding...  
WO/2010/126888A1
Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells i...  
WO/2010/118950A3
The invention relates to a method for producing unsaturated acylamidoalkyl polyhydroxy acid amides, in which the reaction product from polyhydroxy acid lactone and aliphatic diamine is reacted with the anhydride of a simple unsaturated c...  
WO/2010/118951A3
The invention relates to a method for producing monoethylenically unsaturated glycosylamines, in which an aldehyde sugar is reacted with a primary aliphatic amine or ammonia in an aqueous medium and with the anhydride of a simple unsatur...  
WO/2010/117803A3
The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesi...  
WO/2010/117803A2
The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesi...  
WO/2010/115935A1
The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.  
WO/2010/115934A1
The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.  
WO/2010/112649A1
The present invention is intended for use in the chemical industry and relates to a new enzymatic method for obtaining alpha-glycoside derivatives of resveratrol, in which a cyclodextrin glycosyltransferase (CGTase) is used, said CGTase ...  
WO/2010/113151A1
Provided herein are antimicrobial conjugates of two antibiotic agents, exhibiting improved activity also against resistant bacteria, compared to each of the agents separately or their mixture, and having substantially no resistance emerg...  
WO/2010/111777A8
Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of te...  
WO/2010/111777A1
Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of te...  
WO/2010/113960A1
Disclosed are: a thickening-inhibiting agent for inhibiting thickening of the peritoneal membrane by which thickening of the peritoneal membrane can be inhibited, prevented or treated with relieved side effects; and a dialysis solution w...  
WO/2010/111711A2
Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation  
WO/2010/111711A3
Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation  
WO/2010/103857A1
Disclosed are a novel method for the synthesis of a glycopeptide by which glycopeptides of various types can be deprotected and excised from a resin, each under weakly acidic to weakly basic conditions, without causing the problems of th...  
WO/2010/104113A1
Provided is a polyhedral transition metal complex having hollow shells, the hollow shells each comprising n1 transition metal atoms (n1 is an integer of 6-60) and 2(n1) bidentate organic ligands, the bidentate organic ligands having grou...  
WO/2010/101147A1
A hydrogel forming agent comprising a substituted aromatic compound represented by general formula (I) [wherein R is a hydrogen atom or an alkyl; X is an oxygen or sulfur atom; Y1, Y2, and Y3 each is an aryl substituted by a hydrophilic ...  
WO/2010/099279A1
N-Alkoxyamides of 4-aminopicolinnic and-4-pyrimidinecarboxylates of formula (I) are selective herbicides for corn, canola and sugar beet.  
WO/2010/093752A1
The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the structure (I) is disclosed.  
WO/2010/093764A1
The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.  
WO/2010/087207A1
A low-molecular polysulfated hyaluronic acid derivative useful in the prevention and/or treatment of allergic diseases. Provided is a preventive and/or therapeutic agent for an allergic disease selected from pollinosis, allergic rhinitis...  
WO/2010/088192A1
A catheter lock composition for preventing bacterial infection having an effective amount of glycerol and sodium chloride solution. The effective amount of glycerol is between about 35-60% and sodium chloride is in a concentration range ...  
WO/2010/083537A2
Disclosed is the most optimal biomarker for the BIOLOGICAL POTENCY of Emblica Officinalis Gaertn. (AmIa) fruit and products standardized for 5% and above w/w of the said biomarker. Further, the products described herein contain from abou...  
WO/2010/082634A1
Provided are a novel compound which is retained specifically in a tumor, a method for retaining the compound in a tumor, and a method for detecting, diagnosing and treating a tumor using the same. A compound represented by formula (I) or...  
WO/2010/081163A2
Method for selective 2-sulfation of glycosides.  
WO/2010/081163A3
Method for selective 2-sulfation of glycosides.  
WO/2010/073126A3
Conjugate compounds comprising saccharides coupled to bioreductively activated drugs that permeate cell membranes via specific hypoxia- upregulated transporters in hypoxic cells and retain cytotoxic and rediosensitizmg activities. They a...  
WO/2010/073126A2
Described herein are compounds that permeate cell membranes via specific hypoxia-upregulated transporters in hypoxic cells, get bioreductively activated intracellularly, and bind selectively to subcellular macromolecules to demonstrate h...  
WO/2010/072754A1
The invention relates to [6)-O-α-D-Glcp→]1 →]n-6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)-O-α-D-Glcp-(1→]n-6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than th...  
WO/2010/071824A3
Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments,...  
WO/2010/071824A2
Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments,...  
WO/2010/067010A3
The invention relates to derivatives of morphine-6-glucuronide having formula (I) wherein R1 is a 5-membered heteroaromatic group optionally substituted by one or more substituents selected from among halogen atoms and (C1-C4)alkyl, halo...  
WO/2010/066909A3
The present invention relates in general to a compound which is characterized by a formula selected from the following formulas A, B, C, D, E or F; or a pharmaceutically acceptable salt thereof. The present invention further relates to p...  
WO/2010/067010A2
The invention relates to derivatives of morphine-6-glucuronide having formula (I) wherein R1 is a 5-membered heteroaromatic group optionally substituted by one or more substituents selected from among halogen atoms and (C1-C4)alkyl, halo...  
WO/2010/067008A2
The invention relates to compounds having formula (I) wherein: R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 represents a hydroxyl group, a thiol group, a (C1-C4)alkyloxy group or a thio(C1-C4)alkyl group; and n is an integer...  
WO/2010/067007A2
The invention relates to a method for preparing morphine-6-glucuronide or one of the derivatives thereof, comprising the following steps: (i) reacting a compound having formula (I), wherein R1 represents a carbonyl group, COR5CO or S02R6...  
WO/2010/066909A2
The present invention relates in general to a compound which is characterized by a formula selected from the following formulas A, B, C, D, E or F; or a pharmaceutically acceptable salt thereof. The present invention further relates to p...  

Matches 351 - 400 out of 11,735