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JP6382791B2 |
The present invention relates to compounds of formula (I) useful in the treatment of ischemia-reperfusion-related pathologies.
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JP6359495B2 |
The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell ext...
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JP2018100291A |
To provide a method for modulating an immune response characterized by contacting an immune cell with an agent that modulates signaling via PD-1 to thereby modulate the immune response.The invention identifies PD-1 as a receptor for B7-4...
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JP2018516910A |
Processes that limit the effects of surgery on nerves, including the step of applying therapeutic material to nerves during surgery, are disclosed in several forms. In some embodiments, a formulation for reducing nerve trauma, with activ...
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JP2018093882A |
To provide a plasmin inhibitor having reduced anticoagulant activity, with respect to tumorogenesis, angiogenesis, bone remodeling, surgery, hemophilia, orthopedic surgery, coronary artery bypass grafting, and systemic inflammatory respo...
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JP2018515131A |
The present invention is an enzyme, called plasminogenase, for the conversion of plasminogen to plasmin in plasma media containing plasminogen, a solid carrier insoluble in aqueous solution, 0.22 μm. An enzyme composition comprising a s...
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JP2018087226A |
To provide methods and compositions of treating an obstructive coronary artery disease in a mammalian subject.An aromatic-cationic peptide has: at least one net positive charge; a minimum of four amino acids; a maximum of about 20 amino ...
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JP6338259B1 |
To provide a material for regenerating a meniscus capable of further promoting the regeneration of a meniscus. The meniscus regeneration material 10 is used so as to be transplanted into the knee joint in order to regenerate at least a p...
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JP2018512172A |
A method for providing an expanded extracellular matrix of a mammalian organ or its vascularized portion or a mammalian vascularized tissue or its vascularized portion, a mammalian organ or its vascularized portion. An expanded decellula...
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JP6306198B2 |
The present invention provides administrable microparticles in vivo through a medical conduit, a composition comprising the same, and a manufacturing method therefor. The microparticles of the present invention have an advantage that a c...
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JP6285413B2 |
The present invention provides a means for improving water-solubility of polysaccharide. A polysaccharide powder according to the present invention has a particle size distribution in which 30 vol% or more of the total volume of the powd...
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JP6284987B2 |
The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the facto...
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JP6239771B2 |
An object of the present invention is to provide a polymer film that can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The present invention provides a polym...
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JP2017206542A |
To provide a pharmaceutical composition effective for treatment or prevention, suppression, etc. of fibrotic adhesion or peritonitis, ischemia, reperfusion injury, endotoxemia, keloid trauma, keloid, dermatitis, and rosacea.According to ...
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JP6236077B2 |
We describe ultra-short, short, and intermediate duration neuromuscular blocking compounds, reversible by cysteine or similar compounds, that are bisquaternary diesters of chlorofumaric, fumaric, or maleic acids where the quaternary grou...
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JP6235219B2 |
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JP6236445B2 |
Pyridinone derivatives (I) and stereoisomeric forms, E/Z isomers, enantiomers, mixtures of enantiomers, diastereomers, mixtures of diastereomers, racemates, tautomers, anomers, keto-enol forms, betaine form, prodrugs, solvates, hydrates ...
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JP2017165703A |
To provide platelet function-improving compositions which can maintain and/or enhance platelet functions, such as agglutinability of platelets, activation of integrin αIIβ3, promotion of exposure of phosphatidylserine, increase in P-se...
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JP6194335B2 |
Methods of treating, preventing and/or managing cancer as well as diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory com...
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JP2017148075A |
To provide therapeutic compositions and treatments.The invention provides a method and a composition for promoting and/or improving wound healing and/or tissue repair, as well as for anti-scarring, anti-inflammatory, anti-fibrosis and an...
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JP2017145262A |
To provide methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.The invention generally relates to improved uses and methods of administering pirfenid...
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JP2017132817A |
To provide methods of treating and preventing certain types of cancer, including primary and metastatic cancer, as well as cancers that are refractory or resistant to conventional chemotherapy.A pharmaceutical for treating or preventing ...
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JP6168666B2 |
An object of the present invention is to provide an adhesion preventing material capable of preventing adhesion safely and efficiently. The present invention provides an adhesion preventing material comprised of a cell sheet containing m...
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JP2017105794A |
To provide a compound to be a diamine crosslinking agent which can create an acidic polysaccharide crosslinked body for medical material which satisfies all of safety, easy preparation, efficient physical properties alteration and disint...
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JP2017514876A |
The present invention provides a therapeutic placental composition comprising placental cells derived from placental tissue and other placental components. A cryopreserved placental composition is also provided. The placental composition...
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JP2017514507A |
Placental membrane products, including immunocompatible chorion, are provided herein. Such placental membrane products may contain therapeutic factors and viable cells after cryopreservation and thawing. Placental membrane products are u...
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JP6141997B2 |
The present invention provides a method for activating proliferation, migration and differentiation of stem cells in an animal comprising the preparation of the activating agent, the step of administering to the animal an effective amoun...
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JP6135844B2 |
To provide a device for spraying a medical powder inside a body which can stably spray a medical powder such as an anti-adhesive material to the inside of a body together with a pressure gas, enables an intended treatment such as adhesio...
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JP6132853B2 |
The present invention provides a compound that is represented by the following general formula wherein R1, R2, R4, R5, R6, R7, X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP...
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JPWO2016042831A1 |
To provide a therapeutic preparation for examination or surgery of the large intestine, which is mainly composed of magnesium oxide particles and has an excellent intestinal cleansing effect. A therapeutic preparation for colorectal exam...
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JP6117198B2 |
The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analogue sequenc...
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JP2017064431A |
To provide an improved medical device.A medical device useful for limiting or suppressing complications (for example, inflammation and restenosis) associated with an improvement of a tissue damage and/or acceleration of tissue repair and...
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JP6110587B2 |
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JPWO2015099083A1 |
To apply it to a bleeding wound surface by a simple method of applying it in the form of a liquid or a spray mist, and to show an excellent solidifying action on any of plasma, serum and blood. To provide a novel hemostatic material (aqu...
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JP2017018105A |
To provide a method for differentiating mesodermal cells into mesothelial cells.The present invention provides, for example, a method for producing mesothelial cells, the method including a first culture step for culturing mesoderm cells...
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JP6046869B1 |
Carboxymethyl group content ornamentation hyaluronic acid which was excellent in heat stability and enzyme-proof resolvability, and also excellent also in water swelling nature and/or a bridge construction thing of the salt, and a manufa...
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JP2016204382A |
To provide a therapeutic agent for preventing and treating complement-associated disorder by blocking C3b.The present invention relates to a development of an antibody that specifically recognizes not natural C3 but a breakdown fragment ...
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JP6033318B2 |
The present invention provides compounds of Formula (I) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrei...
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JP6023864B2 |
A method of enhancing fat cell survival in a subject in need thereof is disclosed. The method comprising (a) implanting a population of fat cells into the subject; and (b) administering Erythropoietin to the subject, thereby enhancing fa...
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JP6019040B2 |
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherei...
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JP6000974B2 |
The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the facto...
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JP2016172760A |
To provide a tribonectin and a method of tribosupplementation implemented by administering tribonectins directly to an injured or arthritic joint.The tribonectin comprises at least one O-linked lubricating moiety. For example, the lubric...
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JP2016166173A |
To provide an agent for modulating signaling via PD-1.The present invention provides an anti-PD-1 antibody for modulating an immune response, where the antibody modulates the immune response by modulating the interaction of B7-4 and PD-1...
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JP5976272B2 |
A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material w...
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JP2016146767A |
To reduce patient load when producing cultured cartilages effective in therapies.A cultured cartilage production method of the present invention is a production method of a cultured cartilage that is to be implanted into a cartilage defi...
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JP5971715B2 |
The present invention provides a pharmaceutical agent and the like that decreases the level of oxidized albumin. Specifically, the present invention provides an agent for decreasing oxidized albumin, which contains at least one kind of b...
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JP5964538B2 |
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use for treatment of cardiovascular, vascular, neurological, for wounds and for other indications. These compounds and methods ...
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JP5960606B2 |
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no...
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JP2016128491A |
To provide pharmaceutical compositions effective in the treatment, prevention, inhibition, or the like of fibrous adhesion, peritonitis, ischemia, reperfusion injury, endotoxinemia, keloid scar, keloid, dermatitis, or rosacea.The inventi...
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JP5937094B2 |
Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab bre...
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