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JPH1087596A |
To obtain the subject compound useful as an angiotensin II antagonistic agent, etc., in a high yield while forming little by-products by dissolving an imino ether hydrochloride in an organic solvent and adding the solution to ammonia, et...
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JPH10503499A |
PCT No. PCT/EP95/02797 Sec. 371 Date Jan. 23, 1997 Sec. 102(e) Date Jan. 23, 1997 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/04239 PCT Pub. Date Feb. 15, 1996The present invention relates to novel N-alkoxy-arnidine derivatives of the form...
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JP2730713B2 |
To obtain a new compound having an insecticidal activity and also controlling the shape of a noxious organism in agricultural, horticultural and forestall field. This N'-substituted N,N'-diacylhydrazine-based compound is a compound of fo...
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JP2729079B2 |
An aqueous solution containing, as active ingredient, pentamidine or a pharmaceutically acceptable salt thereof, and having a pH of less than 4.5 is more stable than conventional solutions of pentamidine. The pH of the solution is prefer...
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JPH10502646A |
PCT No. PCT/EP95/02113 Sec. 371 Date Mar. 28, 1997 Sec. 102(e) Date Mar. 28, 1997 PCT Filed Jun. 3, 1995 PCT Pub. No. WO96/02496 PCT Pub. Date Feb. 1, 1996The new compound of formula (I) may be prepared by conventional methods and used t...
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JP2715583B2 |
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JPH10501222A |
Compounds of the following general structure X-Y-Z-Aryl-A-B, which inhibit osteoclast mediated bone resorption.
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JP2703754B2 |
To obtain 1,1-dialkoxycycloalkane in one pot by adding a specific secondary alkanol and a specific cycloalkanone to an anhydrous reaction mixture of hydrogen cyanide, hydrogen chloride and the specific secondary alkanol and reacting the ...
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JPH101467A |
To obtain a new compound useful as a new anticoagulant having conquered the defect of a conventional anticoagulant, having an inhibitory action on blood coagulation and dissolving action on thrombus and embolus, having a specific structu...
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JPH09316078A |
To readily obtain the subject compound for an intermediate or the like of pyrazolo[5,1-c]-1,2,4-trizole compound useful as a color-forming coupler or the like for image-forming in photography by reacting a specific hydrazide derivative o...
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JP2680196B2 |
A compound with a platelet aggregation inhibitor activity, represented by the following general formula (I), and pharmacologically acceptable salt and solvate thereof. Examples of the compound are as in (II).
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JPH09511529A |
PCT No. PCT/GB95/02417 Sec. 371 Date Jun. 4, 1996 Sec. 102(e) Date Jun. 4, 1996 PCT Filed Oct. 12, 1995 PCT Pub. No. WO96/11902 PCT Pub. Date Apr. 25, 1996The invention relates to compounds of the formula (I): (I) wherein A, B and D are ...
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JPH09510213A |
This invention relates to a process for preparing the ketone of formula II where R1 is hydrogen or another a substitutent, which process comprises cyclizing a compound of formula A where alk is alkyl of 1 to 6 carbon atoms.i
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JPH09249628A |
To obtain the subject novel compound highly safe and excellent in suppressing action on lipid peroxidization, suppressing action on macrophage foaming, suppressing action on growth of LDL oxide, etc., useful as prevention or therapeutic ...
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JP2650823B2 |
An N-aryloxyacyl-N-phenyltetrahydrophthalamic acid derivative represented by general formula (I), a process for producing the same, and a herbicide containing the same as the active ingredient, which is very useful as a herbicide because...
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JPH09508099A |
(57) [Summary] The present invention is a compound capable of introducing at least one molecule into a cell and formula (I) :.(A in the formula is a hydrophilic group or CH2Selected from the group consisting of groups containing groups a...
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JPH09208507A |
To synthesize a radioactive halogenated small molecule for the protein labeling used in in-vitro diagnostic measurement of ferritin concentration in serum. In order to synthesize a radioactive halogenated small molecule represented by th...
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JPH09194451A |
To very readily and industrially obtain a cyanoamidine useful as a synthetic precursor of an insecticide as an agrochemical from only inexpensive N-substituted amide without using expensive N-cyanoimidate. An N-substituted amide of formu...
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JPH09194406A |
To obtain the subject compound useful for clinic diagnosis and suitable as a diagnostic agent and a therapeutic agent, especially in vitro diagnostic measurement of ferritin in serum. This radioactive compound is shown by the formula *X-...
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JPH09176106A |
To obtain a compound important for studying a mutual action of a liberated glucide or a glucide of a glycoconjugate and a specific receptor, containing a chromophore and a group bondable to streptavidin and/or avidin, suitable for being ...
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JP2624227B2 |
PURPOSE: To granulate an azobisamidine salt into a salt, excellent in operating efficiency, granule strength and stability with time, hardly causing unfavorable effects due to sticking, etc., of dust and useful as a polymerization initia...
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JPH09505043A |
Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q(CO2R6 or OH), -CN, -C(R7)=NOR8, NO2, -O(lower alkyl)R9, -C=C-R10, -CR11=C(R12)(R13), -C(=O)CH2C(=O)CO2H, -CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, ...
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JP2606643B2 |
PURPOSE: To provide the subject new compound having inhibitory activity at extremely low concentrations on serine proteases such as trypsin, thrombin, or factor Xa. CONSTITUTION: The objective compound of formula I (R1 and R2 are each H,...
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JPH09504524A |
PCT No. PCT/US94/11724 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Oct. 18, 1994 PCT Pub. No. WO95/11014 PCT Pub. Date Apr. 27, 1995The current invention discloses amidino derivatives useful as nitric oxide synth...
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JP2605762B2 |
A compound of the formula wherein R<1> and R<4> are independently amino or an organic residue bonded through nitrogen, R<2> is hydrogen or alkyl which may be substituted, R<3> is hydrogen or a protecting group and R5 is hydroxyl which ma...
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JP2593312B2 |
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JP2588683B2 |
PURPOSE: To advantageously and industrially obtain the subject compounds useful as water scavengers in org. reactions and solvents by reacting hydrogen cyanide (derivative), hydrogen chloride and secondary alkanol anhydrously in an org. ...
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JPH0959242A |
To obtain a granule, excellent in stability of an azobisamidine salt, good in operating efficiency without causing the caking, bridging, etc., hardly scattering dust and useful as a polymerization initiator for the aqueous solution or em...
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JPH09501918A |
The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include stroke, schizophrenia, anxiety, and pain.
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JPH09501651A |
PCT No. PCT/GB94/01325 Sec. 371 Date Mar. 18, 1996 Sec. 102(e) Date Mar. 18, 1996 PCT Filed Jun. 20, 1994 PCT Pub. No. WO95/00505 PCT Pub. Date Jan. 5, 1995Compounds of formula (I) and salts, esters and amides thereof, wherein R1 is a C1...
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JPH0940631A |
To obtain an agent for the treatment of mite allergy by using an active component consisting of a specific amidinophenol derivative having strong inhibitory action on house dust mite protease and exhibiting excellent absorbability. This ...
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JP2576865B2 |
Certain novel N-substituted-N min -substituted-N,N min -diacylhydrazines are useful insecticides, especially against insects of the order Lepidoptera and Coleoptera. The insecticides, compositions containing them and their use are disclo...
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JPH0912558A |
To easily, generally and economically obtain 1,2,4-triazolium and 1,2,4-triazoline by using an amidrazone and a carboxylic acid, etc., as starting substances. One of the objective compounds, a 1,2,4-triazolium salt of formula II (A is an...
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JP2568408B2 |
Granules of azobisamidine salt can be produced by granulating a powder of azobisamidine salt using a limited amount of water or a mixture of water and a water-soluble organic solvent such as methanol are convenient in handling without de...
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JP2565602B2 |
Compounds of the formula I in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, d...
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JP2565710B2 |
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JPH08512024A |
The invention concerns acid derivatives of formula I R<1>-CON(R<2>)-N(R<3>)CO-X<1>-Q-X<2>-G I and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, wherein R<1> repr...
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JPH08333324A |
PURPOSE: To obtain a new benzene derivative having strong suppressing actions on blood platelet aggregation and antithrombin actions based on the antagonistic actions on fibrinogen receptors as a mechanism and useful as a preventing and ...
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JPH08311007A |
PURPOSE: To obtain the subject new compound exhibiting excellent vasodilative action, useful as a therapeutic agent for hypertension, angina pectoris, myocardial infarction, and cardiac insufficiency. CONSTITUTION: This compound is expre...
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JP2554900B2 |
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JP2554883B2 |
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JP2547207B2 |
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JP2545475B2 |
Compounds of formula I and their salts in which n = 0 or 1, R1 and R2 are each aliphatic or cycloalkyl or NR1R2 is an optionally substituted heterocyclic ring, R3 is alkyl, cycloalkyl or optionally substituted amino, R5 is an aliphatic g...
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JPH08268949A |
PURPOSE: To obtain the subject derivative having acetylcholine activating action and monoamine activating action (esp. serotonin activating action), thus useful for preventing, treating or remedying dementia involved in cerebrovascular l...
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JPH08245526A |
PURPOSE: To obtain optically active new amines or imines having C2 symmetry functioning as asymmetric sources of important highly selective asymmetric synthesis in synthesis of intermediates for medicines or agrochemicals. CONSTITUTION: ...
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JPH08188564A |
PURPOSE: To obtain the subject antagonist containing a novel compound useful for thrombosis prevention, because of its effects of inhibiting glycoprotein IIb/ IIIa fibrinogen receptor, and thereby inhibiting platelet aggregation and clot...
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JPH08505862A |
Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-argininamide-acetate.
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JP2509583B2 |
This invention is concerned with insecticidal compositions containing N'-substituted-N,N'-diacylhydrazines, methods of using such compositions and with certain of the insecticidal N'-substituted-N,N'-diacylhydrazines which are novel comp...
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JPH08143490A |
PURPOSE: To obtain the subject new compound useful for labeling an antibody, and the subject new labeled protein labeled by the compound and useful as a diagnostic agent and therapeutic agent for clinical diagnosis and treatment. CONSTIT...
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JPH08143529A |
PURPOSE: To obtain an amidinophenol derivative useful for preventing and treating inflammatory and allergic diseases, disseminated intravascular coagulation, pancreatitis, multiple organ disorder, etc. CONSTITUTION: Thus compound of form...
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