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JP2501252B2 |
Acetic acid derivatives of formula H2N(NH)C-X-Y-CO-Z-CH(Q1)COOQ2 (I), their hydrates, solvates and salts. In (I), Q1 = H, CH3 or phenyl. Q2 = H, phenyl-alkyl or physiologically-cleavable alkyl. X = 1,4-phenylene, 2,5- or 3,6-pyridylene o...
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JPH08127563A |
PURPOSE: To obtain a novel benzyloxyhydrazone derivative which manifests excellent effect as a microbicidal agent for agriculture and horticulture, particularly against tomato's late blight, cucumber Botrytis cinerea or barley powdery mi...
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JPH0816087B2 |
The compound of the formula wherein R<1> is hydrogen, hexanoyl, or sorbyl, R<2> is hydrogen or methyl, R<3> is an amino which may optionally be protected, and R<4> is hydroxyl or 2-amidino-ethylamino, with the proviso that when both R<1>...
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JPH0834775A |
PURPOSE: To efficiently obtain the subject compound without using a highly dangerous azide compound as a reagent by reacting a nitrile with hydrogen sulfide and reacting the reaction product with hydrazine and a nitrous acid compound. CO...
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JPH089589B2 |
Compounds of formula I (* CHEMICAL STRUCTURE *) I and their salts in which R1 is optionally substituted phenyl, R2 is alkyl, cycloalkyl or optionally substituted amino, or R2 and R3 together with the nitrogen and carbon atoms to which th...
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JPH085848B2 |
The novel carboxylic acid and sulphonic acid amides of the formula R<1>-A-(W)a-X-(CH2)b-(Y)c-B-Z-COOR (I) in which R<1>, A, W, X, Y, B, Z, R, a, b and c have the meaning given in the description, can be used in the treatment of throm...
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JPH07121900B2 |
A process for preparing a compound of the formula : wherein R<2> is lower aliphatic hydrocarbon group which may be substituted with suitable substituent(s), cyclo(lower)alkyl or cyclo(lower)alkenyl; or a salt thereof, which comprises rea...
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JPH07330695A |
PURPOSE: To provide a new carboxylic acid derivative which is represented by a specific formula, has excellent GPII/IIIa antagonism against mammalian including human, can be orally (or parenterally) given, has the long life in blood with...
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JPH07108891B2 |
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JPH07206801A |
PURPOSE: To obtain a new compound having an inhibitory effect on phospholipase A2 and a protease and useful for prevention and/or therapy of inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis a...
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JPH0768224B2 |
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JPH07179407A |
PURPOSE: To obtain a low toxic new condensed cyclic compound having excellent glycoprotein GPIIb/III antagonistic activity, capable of oral administration, long in blood life, having low side effects, thus useful for preventing and treat...
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JPH0759545B2 |
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JPH07165693A |
PURPOSE: To obtain the subject compound useful for controlling insects which destroy cultivated plant crops, ornamental plants or forestry plants, especially lepidopterons, and an insecticidal composition containing it. CONSTITUTION: The...
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JPH0749409B2 |
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JPH0749408B2 |
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JPH07138221A |
PURPOSE: To obtain a new amidino compound useful as a glycoprotein IIb/IIIa antagonism, an inhibitor of blood platelet agglutination, a preventive and/or therapeutic agent for thrombosis. CONSTITUTION: A compound of formula I [R1 is amid...
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JPH0742262B2 |
An improved process for preparing a dialkyl propanediimidate dihydrohalide by reacting malononitrile, an alcohol, and hydrogen halide, wherein the improvement comprises conducting the reaction under greater than atmospheric pressure in a...
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JPH07502970A |
There are provided novel 1,4-diamine-2,3-dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.
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JP7082229A |
PURPOSE: To obtain new N-alkylacetamidines useful as an intermediate for producing N-alkylacetamides useful as a germicide for agriculture. CONSTITUTION: N-Alkylacetamidines expressed by formula I (X1 to X3 are H, lower alkyl, lower alko...
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JPH0782095A |
PURPOSE: To suppress deposition of fine crystals and small crystals and obtain large-sized organic single crystals having good transparency by evaporating or cooling a solvent in an organic solvent solution of a specific organic material...
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JPH0782252A |
PURPOSE: To produce the subject compound for a raw material of a photographic coupler by reacting a nitrile with an alcohol in the presence of a base to synthesize an imidic acid ester and subsequently reacting an aminopyrazole and a hyd...
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JPH07502533A |
The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes virus...
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JPH06102641B2 |
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...
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JPH06102640B2 |
N-Aroyl- alpha -aminocarboxylic acid derivatives of the formula in which L, R' to R''' and Q have the meaning given in the description, can be used for the treatment or prophylaxis of diseases which are caused by the binding of adhesive ...
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JPH0684340B2 |
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JPH0684341B2 |
A herbicidal phenylhydrazone derivative of oxamide is represented by the formula (I): wherein R<1> is a straight-chain alkyl group having from 2 to 10 carbon atoms, branched alkyl group or cyclic alkyl group having from 3 to 10 carbon at...
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JPH0678291B2 |
Compounds of the formula I where R is alkyl of 1 to 10, preferably 1 to 4, carbon atoms, X is O or S, Y is hydrogen or nitrophenyl which is unsubstituted or substituted by chlorine, bromine, methoxy or methyl, when n is 1, and is C2-C6-a...
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JPH0678294B2 |
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JPH06279389A |
PURPOSE: To obtain a novel compound having antagonism against GPIIbIIIa receptor on the surface of platelet and high safety and useful as an antithrombotic agent and a platelet aggregation inhibitor. CONSTITUTION: A compound of the formu...
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JPH06234667A |
PURPOSE: To obtain an aromatic bromomethyl compound in extremely pure form which is a useful intermediate in the synthesis of active substances. CONSTITUTION: A method characterized by using chlorobenzene as a solvent in preparatioh of a...
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JPH0662567B2 |
Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: (A) wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds rep...
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JPH06220001A |
PURPOSE: To obtain novel 3-imino-3-alkoxy-propionic acid lactates which is important in 1,4-dihydropyridine compounds and useful as valuable intermediates for the synthesis of polarizing 2-amino-dihydropyridines. CONSTITUTION: By first r...
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JPH06220005A |
PURPOSE: To provide novel imino ethers useful as light stabilizer for polymeric materials, particularly for finishing coatings for cars containing organic polymers. CONSTITUTION: A compound of formula I [wherein (n) is 1 to 3; Y represen...
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JPH06157444A |
PURPOSE: To provide a new compound having excellent insecticidal characteristics for armyworm, mite etc., useful as a pest controlling agent safely usable with assured effect. CONSTITUTION: The compound of formula I(X is halogen, alkyl, ...
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JPH0637453B2 |
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JPH0637483B2 |
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JPH06135925A |
PURPOSE: To provide the substituted ethanediimidamides useful as intermediates for preparing histamine H2-receptor antagonists which are effective in treating a hypersecretion abnormality such as gastric ulcer or the like. CONSTITUTION: ...
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JPH0635444B2 |
Disclosed herein are adrenergic compounds represented by the formula wherein m is 0, 1 or 2; R1, R2, R3 are taken from the group consisting of hydrogen, hydroxy, loweralkyl, loweralkoxy, halo, or NHSO2R wherein R is taken from the group ...
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JPH0629246B2 |
NEW MATERIAL:The 2-(5-fluoronicotinoyl)acetic acid derivative of formula I (R<1> is group capable of forming carboxyl-protecting group; R<2> is halogen, hydroxy, 3-aminopyrrolidinyl, piperazinyl, alkoxy, alkylthio, arylthio, alkanesulfon...
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JPH0625100B2 |
An azoimino ether, which is an intermediate for preparing polymerization initiators, can be produced by reacting a hydrazonitrile having a hydrazo group and at least one cyano group in the molecule with chlorine in the presence of a prim...
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JPH0673038A |
PURPOSE: To obtain the new compounds useful as medicines having an inhibitory effect on inflammation or bone degradation, an antithrombotic action, an anticoagulant action and an inhibitory action against tumor and its metastasis. CONSTI...
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JPH0650977A |
PURPOSE: To obtain a fibrinogen receptor antagonist useful for measurement of the concentration of ligand, fibrinogen receptor antagonist being used in bonding test of fibrinogen receptor. CONSTITUTION: A fibrinogen receptor antagonist h...
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JPH0610179B2 |
The compound of the formula I wherein R1, R2 and R3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and ar...
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JPH06501002A |
N,N'-disubstituted-amidines, e.g., of the formula or unsubstituted hydrocarbon and/or heterocyclic groups. Methods are provided for the treatment or prophylaxis of anxiety in an animal for treating psychosis, and for treating hypertensio...
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JPH0588788B2 |
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JPH05320531A |
PURPOSE: To provide microcapsules that contain a specified compound held in an organic cosolvent vehicle capable of forming a colored complex with a transition metal salt, have good image-forming properties, and are useful for carbon-les...
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JPH05310650A |
PURPOSE: To obtain a new compound, having remarkable insecticidal characteristics, safely usable and useful as an insecticide effective against especially Aphis gossypii Glover or Nephotettix cincticeps. CONSTITUTION: The compound of for...
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JPH0568472B2 |
Substituted ethanediimidamides of the formula wherein m is 0-2, n is 2-5, Z is O, S or methylene, R<1> is H or alkyl and A is exemplified as piperidino - or pyrrolidino - methylphenyl, dimethylaminomethyl-furyl or thienyl, or piperidinom...
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JPH05239008A |
PURPOSE: To produce a new arylether useful for treating rheumatoid arthritis, inflammatory intestinal disease, psoriasis, non-steroid anti-inflammatory agent- induced stomach disease, adult dyspnea syndrome, myocardial infarct. etc., as ...
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