| Document |
Document Title |
|
JP2001521484A |
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
|
|
JP2001519841A |
(57) [Summary] The present invention includes novel ligands that can be used as part of a catalytic system. The catalytic system of the present invention is a transition metal-ligand complex. More specifically, the catalytic system conta...
|
|
JP2001519808A |
The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.
|
|
JP3220733B2 |
PURPOSE: To obtain new N-alkylacetamidines useful as an intermediate for producing N-alkylacetamides useful as a germicide for agriculture. CONSTITUTION: N-Alkylacetamidines expressed by formula I (X1 to X3 are H, lower alkyl, lower alko...
|
|
JP2001514654A |
The present invention provides compounds having the structureAr1-Q-Ar2-O-(CH2)n-Zand pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB4 product...
|
|
JP3205558B2 |
There is provided the combination of acetylsalicylic acid and a compound of the general formula I A<1> - A<2> - NH - (CH2)n - B wherein A<1>, A<2>, n and B have meanings given in the description, for use in therapy.
|
|
JP3203579B2 |
This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide group of the substrate peptide has been replaced by a substituted malonyl moiety. The contemplated peptidase inhibitors of the for...
|
|
JP3202960B2 |
To obtain a halogenating agent capable of halogenating a hydroxyl group in a stable yield in a high purity and in a short reaction time without producing by-products in which one or more sites except the target hydroxyl group are halogen...
|
|
JP2001220375A |
To obtain a new amide compound or its salt, in detail, a new amide compound having a pharmacological activity such as 5-hydroxytryptamine (5-HT) antagonism, etc., or its salt.This compound is represented by general formula (I) R1-A- X-NH...
|
|
JP2001510797A |
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
|
|
JP2001510481A |
The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.
|
|
JP2001192364A |
To provide a novel synthetic intermediate for hydroxamic acid derivative that has high inhibitory activity against MMPs and increased solubility in water. This novel compound is represented by general formula (1). In an embodiment, this ...
|
|
JP3188286B2 |
PURPOSE: To provide the title compound useful as an agricultural bactericide excellent in efficacy, safety and practicability, etc. CONSTITUTION: The objective compound of formula I (X is H, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, m...
|
|
JP3183724B2 |
PURPOSE: To obtain a new amidinocyclohexane derivative, having inhibitory action on proteolytic enzymes and useful as a medicine. CONSTITUTION: The amidinocyclohexane derivative of formula I [R is phenyl which may have a substituent grou...
|
|
JP2001507690A |
The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula IwhereR1, R2 are each hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, -OR5, -OCOR6, -OSO2R6, -SH, -S(O)nR7, -SO2OR5, -...
|
|
JP3171850B2 |
PCT No. PCT/GB92/02387 Sec. 371 Date Jun. 22, 1994 Sec. 102(e) Date Jun. 22, 1994 PCT Filed Dec. 23, 1992 PCT Pub. No. WO93/13055 PCT Pub. Date Jul. 8, 1993 (I) Amidino derivatives of formula (I) and salts, and pharmaceutically acceptabl...
|
|
JP2001055370A |
To obtain an alkylimide ether sulfate with industrial advantage by allowing an aliphatic nitrile and an alcohol to react with sulfuric acid under mild reaction conditions with reduced corrosion of installation, for example, reactor or th...
|
|
JP2001502326A |
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF- alpha converting enzyme (TACE, tumor necrosis f...
|
|
JP2001501943A |
The invention concerns fungicidal compounds, and compositions containing them, of general formula (I) in which G is selected from the groups G1 to G9: (a) in which the different symbols represent various organic groups. The invention als...
|
|
JP2001031637A |
To obtain a new compound comprising a hydroxamic acid derivative, capable of inhibiting metalloproteinases and excellent in physiological activities such as percutaneous absorbability or oral absorbability. This compound is represented b...
|
|
JP2001501174A |
The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glyc...
|
|
JP2001500864A |
A compound which inhibits human thrombin and which has general structure (I) such as formula (a).
|
|
JP2000517325A |
A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or...
|
|
JP2000515493A |
The present invention relates to a class of compounds represented by Formula Ior a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antag...
|
|
JP2000514815A |
A composition, which comprises at least one compound of the formulain which A1, A2, R1 and R2 are as defined in claim 1, or, if appropriate, an E/Z isomer, an E/Z isomer mixture and/or a tautomer thereof, in each case in free form or in ...
|
|
JP2000513374A |
The present invention discloses new processes in the preparation of midazolam (VII), a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.
|
|
JP2000273078A |
To obtain the subject compound industrially advantageously by using various amidoxime derivative as starting materials, forming O-acyl compound by using a prescribed acylating compound, then acting hydrogen in the presence of suitable so...
|
|
JP2000510820A |
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
|
|
JP2000510832A |
The invention is an oxazolidine ester of silylated baccatin III of formula (VII)which is a useful intermediate to produce pharmaceutically useful anti-cancer compounds.
|
|
JP2000508677A |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
|
|
JP2000191618A |
To produce the subject hydrochloride in a high yield while facilitating the control of reactional temperature and excellent in operations by adding a nitrile compound to an alcohol solution containing hydrogen chloride dissolved therein....
|
|
JP2000178243A |
To obtain the subject new compound clinically applicable and useful as a selective activated blood coagulation factor X (hereinafter abbreviated to Fxa) inhibitor.This biphenylamidine derivative is represented by formula I [A1 is amidino...
|
|
JP2000506538A |
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or...
|
|
JP2000504320A |
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
|
|
JP2000080154A |
To provide a curing agent and a cure accelerator reduced in the tendency to sublime or to decompose and giving a resin composition having improved heat stability and a prolonged pot life when added to a resin by selecting a clathrate com...
|
|
JP3020510B2 |
Disclosed are new perfluoroaminoether polymers and a process for preparing them which comprises copolymerizing fluorinated olefins with certain oxaziridines in the presence of UV radiation or of chemical initiators.
|
|
JP2000502082A |
Compounds of formula (I): (I) wherein: n, A, R1, R2, R3, and R4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants.
|
|
JP3009505B2 |
N-Phthaloyl-O-benzyl oxime ethers (I) are new. X = CH2, CH(1-4C alkyl), CH(1-4C alkoxy), CH(1-4C alkylthio or N(1-4C alkoxy); Y = O, S or NR4; Z1, Z2 = H, halogen, methyl, methoxy or cyano; R1, R2, R4 = H or 1-4C alkyl; R3 = H, halogen, ...
|
|
JP2000501390A |
The invention relates to new amino acid derivatives of general formula (I), wherein B, T, Z, Y, V and n are defined as in claim 1, the tautomers, diastereomers and enantiomers thereof, the mixtures thereof and the salts thereof, particul...
|
|
JP2000501083A |
New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH antagonists and their salts. The disclos...
|
|
JP2000500469A |
A compound of Formula II: wherein: R 1 and R 2 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl or alkylaminoalkyl; R 3 is H, loweralkyl, oxyalk...
|
|
JPH11514980A |
2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positio...
|
|
JPH11514631A |
PCT No. PCT/EP96/04575 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Oct. 22, 1996 PCT Pub. No. WO97/16415 PCT Pub. Date May 9, 1997Phenylcarbamates of the formula I where the substituents and the index have the fo...
|
|
JP2989010B2 |
The invention relates to an intermediate of formula (VI) or a protected derivative thereof, wherein Q is hydrogen or a carboxyl protecting group and Q' is a protecting group. Such intermediates are useful for the preparation of amidino s...
|
|
JP2990042B2 |
|
|
JP2984498B2 |
PURPOSE: To obtain a compd. having an inhibiting activity against L-arginine/ nitrogen oxide synthetase and an inhibiting activity against cyclooxygenaze, which is useful for therapy of heart and cerebrovascular disorders, inflammation a...
|
|
JPH11512428A |
There is disclosed a novel amino alcohol amine derivatives of L-N6-(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
|
|
JP2951875B2 |
|
|
JPH11509540A |
PCT No. PCT/FR96/01095 Sec. 371 Date Jan. 6, 1998 Sec. 102(e) Date Jan. 6, 1998 PCT Filed Jul. 15, 1996 PCT Pub. No. WO97/03678 PCT Pub. Date Feb. 6, 1997Cyclo-oxygenase inhibitor and amidine derivative salts, preparation methods therefo...
|
|
JPH11509189A |
Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1-C4alkyl; R2 is hydrogen, C1-C4alkyl or cyclopropyl; and in which R3 and R4 are as ...
|
