| Document |
Document Title |
|
JPH11509208A |
The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]am
ino]-4-pentynoate and pharmaceutically acceptable acid addition salt thereof which comprises treat...
|
|
JP2931410B2 |
PCT No. PCT/EP95/02112 Sec. 371 Date Mar. 28, 1996 Sec. 102(e) Date Mar. 28, 1996 PCT Filed Jun. 3, 1995 PCT Pub. No. WO96/02497 PCT Pub. Date Feb. 1, 1996Compounds of formula (I) and their therapeutic use, inter alia, as LTB4-antagonist...
|
|
JPH11508248A |
Compounds of the formula I in which Z is -CO-NHNH2, COOH, COCl, CONHNHCOR4 or CON=C(R4)NMe2 are intermediates for the preparation of compounds of the formula I in which Z is a group a) or b) or c) or d) The end compounds can be used for ...
|
|
JPH11193266A |
To obtain a silver halide photographic material excellent in image quality such as sharpness, graininess, resolving power or color reproducibility and providing a stable and ultrahigh contrast image even by treatment with a developer at ...
|
|
JPH11193265A |
To obtain the subject new compound capable of being synthesized by using an inexpensive secondary raw material without a complicated purification step and useful as an intermediate for an aromatic amidine derivative having anticoagulant ...
|
|
JP2920556B2 |
|
|
JPH11507930A |
Carboxylic acid amide derivatives having formula (I) are disclosed, as well as several processes for preparing the same and their use as fungicides. In formula (I), Ar stands for optionally substituted arylene or heteroarylene; E stands ...
|
|
JP2916418B2 |
|
|
JP2901509B2 |
Acetic acid derivatives of the formula in which L, M, Q and T have the meaning stated in the description, can be used for the treatment or prophylaxis of diseases caused by the binding of adhesive proteins to blood platelets, and by aggr...
|
|
JP2895913B2 |
A butenoic acid compound is defined by the following formula:in which Z is O,S, vinylene or azomethyne, A is an alkylene and J is phenyl or etc. It is useful to treat the heart disease.
|
|
JPH11140040A |
To provide the subject new compound having an excellent activity for inhibiting the activated blood coagulation factor X and useful as an activat ed blood coagulation factor X inhibitor. A compound of formula I {R1 is H, OH or a lower al...
|
|
JPH11505240A |
PCT No. PCT/GB96/01191 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed May 17, 1996 PCT Pub. No. WO96/36325 PCT Pub. Date Nov. 21, 1996Use of amine and amidine containing compounds of formula (I) such as galegine and...
|
|
JP2889377B2 |
|
|
JPH11504630A |
PCT No. PCT/EP96/01615 Sec. 371 Date Dec. 17, 1997 Sec. 102(e) Date Dec. 17, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33970 PCT Pub. Date Oct. 31, 1996The present invention relates to phenyl amidines of general formula (I), in whic...
|
|
JP2887397B2 |
New pentamidine analogue compounds and compositions containing the new analogues are disclosed. Methods for the treatment of, and prophylaxis against, Pneumocystis carinii pneumonia, and methods for treating leishmaniasis, giardiasis, an...
|
|
JP2879718B2 |
An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: wherein the group represented by is a group selected from indolyl, benzof...
|
|
JP2860222B2 |
Pseudopeptides of formula I in free or salt form wherein A, B, R1, X, Y and m are defined as in claim 1, and their use in the prophylactic and acute treatment of thrombosis.
|
|
JPH11502194A |
This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with ...
|
|
JP2850943B2 |
Novel compound, 2,2-bis(4-carboxyphenyl)hexafluoropropane bisamidrazone, obtained by conversion of the carboxy groups of 2,2-bis(4-carboxyphenyl)hexafluoropropane to acid chloride groups, followed by reaction with ammonia; dehydration re...
|
|
JPH115780A |
To obtain a new compound having a high selectivity for thrombin and against trypsin and useful as a new orally administrable thrombin inhibitor. This thrombin inhibitor is a compound of formula I [R1 is acetyl which is substituted with a...
|
|
JP2844329B2 |
The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: in which R<1> represents acetyl substituted with aryl or aryloxy, or represents sulfo...
|
|
JP2839371B2 |
Light activated acyl-enzymes of the formula: (III) are disclosed. In the compounds of Formula (III), ENZ is an enzyme, X is O or S, Y is -NR3R4, -OR5, or -SR5, and Z is a nucleophile. m is 0 to 3 and n is 1 or 2. Y is substituted on the ...
|
|
JP2835123B2 |
The invention provides a stabilised aqueous solution of a water soluble pentamidine salt comprising an acetate buffer, and having a total acetate concentration of 0.01-0.06M, and a pH of 4.0-5.0 at room temperature.
|
|
JP2836215B2 |
|
|
JP2834112B2 |
To obtain the subject new compound exhibiting muscarinelike antagonist activity or mixed agonist/antagonist activity and therefore effective for the treatment and prevention of e.g. diseases characterized by excessive cholinerqic activit...
|
|
JPH10287637A |
To provide a new amidine derivative having antagonistic action on neuropeptide Y receptor and useful as an agent for the treatment or prevention of hyperphagia, obesity and diabetes. This compound is expressed by formula I {(n) is 0-6; (...
|
|
JP2813462B2 |
Novel substituted beta amino acid derivatives having the general formula: are provided, in which eg. R<2> is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicyclic ...
|
|
JPH10510539A |
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic a...
|
|
JPH10510537A |
PCT No. PCT/US95/15937 Sec. 371 Date Jun. 13, 1997 Sec. 102(e) Date Jun. 13, 1997 PCT Filed Dec. 7, 1995 PCT Pub. No. WO96/18602 PCT Pub. Date Jun. 20, 1996This invention relates to compounds of the formula: which are effective for inhib...
|
|
JP2809280B2 |
A series of novel imidate insecticides distinguished by the general formula in which R1 is an optionally substituted aryl group in which the substituents are halo, C1-C4 alkyl, C1-C4 haloalkoxy, C1-C4 alkoxy, C1-C4 haloalkylthio, C3-C6 c...
|
|
JP2804077B2 |
Fluoropolyethers having functional groups, comprising sequences of statistically distributed perfluoropolyoxyalkylene units selected from: and having one of the following formulae: (II) T min -O(CF2CF2O)p(CF2O)sCRR min -Y wherein T, T mi...
|
|
JP2795986B2 |
PCT No. PCT/US93/10876 Sec. 371 Date Jul. 25, 1995 Sec. 102(e) Date Jul. 25, 1995 PCT Filed Nov. 12, 1993 PCT Pub. No. WO94/11341 PCT Pub. Date May 26, 1994 (I) The invention relates to the compounds of formula (I) wherein the C(=NH)-NHR...
|
|
JPH10509156A |
PCT No. PCT/EP95/04357 Sec. 371 Date May 1, 1997 Sec. 102(e) Date May 1, 1997 PCT Filed Nov. 6, 1995 PCT Pub. No. WO96/16026 PCT Pub. Date May 30, 1996Compounds of formula (I), wherein Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2,...
|
|
JPH10237036A |
To efficiently and simply synthesize an optically active amidine by reacting an imide eater with an amine immobilized on solid granules in the presence of a mixture solution comprising a halogenated hydrocarbon, a base and a lower alcoho...
|
|
JP2789047B2 |
The present invention relates to a new method of synthesis of 2,2 min -bis DELTA <2>-oxazoline, which consists of three steps: in the first step, N,N min -bis-(2-hydroxyethyl)-oxamide (I) is reacted with hydrogen chloride and a nitrile o...
|
|
JPH10218839A |
To obtain the subject new compound having an alkoxy-substituted methylidene group bonded to an acetic acid part and a substituent of a benzene ring bonded through ethylene group, exhibiting excellent herbicidal activity at a reduced rate...
|
|
JPH10218853A |
To easily obtain an isoimide by reaction of a compound bearing carboxyl and amide groups in the identical molecule in the presence of a haloiminium salt and a basic substance. This isoimide bearing an isoimido linkage of formula III in t...
|
|
JPH10182581A |
To obtain a raw material intermediate which is effective as an insecticide raw material and inexpensive in production of bromide and free from problem such as occurrence, etc., of eutrophicated drainage. N,N-Dimethylformamide is reacted ...
|
|
JPH10182582A |
To obtain a raw material intermediate which is effective as an insecticide raw material and inexpensive in production of bromide and free from problem such as occurrence, etc., of eutrophicated drainage. N,N-Dimethylformamide is reacted ...
|
|
JPH10506390A |
Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of in...
|
|
JPH10505075A |
The present invention relates to new imidic acid derivatives of the formula (I)to a plurality of processes for their preparation, and to their use as pesticides.
|
|
JP2750875B2 |
|
|
JPH10504799A |
Compounds of formula (I) in which X is (a) or (b), n is 0, 1, 2, 3, 4 or 5, where if n is greater than 1, the radicals R2 are identical or different; o is 0, 1, 2, 3 or 4, where if o is greater than 1, the radicals R3 are identical or di...
|
|
JPH10114724A |
To obtain the new subject compound which is an inhibitor for phosphodiesterases in the IV group and useful for therapeutic applications relating to inflammation and relaxation of bronchus, and asthma, chronic obliterative bronchitis, chr...
|
|
JP2747928B2 |
|
|
JP2744304B2 |
|
|
JPH10101627A |
To efficiently obtain a trihalocrotonate compound useful as a synthetic intermediate for agrochemicals, medicines, etc., by producing a mixture of a specific trihaloacetoacetate derivative with an amine salt, etc., and heating the mixtur...
|
|
JPH1095762A |
To obtain the novel subject compound which has nitrogen monoxide synthetase inhibitory action and is useful for cerebrovascular disorder (cerebral apoplexy) and the like. The objective compound is represented by formula I [R1 is a (subst...
|
|
JP2736967B2 |
Amidinophenol derivatives of the formula (I): wherein R<1> and R<2> are (i) H, (ii) C1-4 alkyl, (iii) C1-4 alkoxy, (iv) C2-5 acyl, (v) halogen, (vi) NO2, (vii) benzoyl, (viii) COOR<4>(in which R<4> is C1-3 alkyl); A is bond, C1-4 alkylen...
|
|
JP2736952B2 |
Amidinophenol derivatives of the formula (I): wherein R<1> and R<2> are (i) H, (ii) C1-4 alkyl, (iii) C1-4 alkoxy, (iv) C2-5 acyl, (v) halogen, (vi) NO2, (vii) benzoyl, (viii) COOR<4>(in which R<4> is C1-3 alkyl); A is bond, C1-4 alkylen...
|
