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JP3370998B2 |
The invention relates to the compounds of the formula and pharmaceutically acceptable salts thereof, in which: R1 is amino which is mono- or disubstituted by a substituent selected from an aliphatic hydrocarbon radical, an araliphatic hy...
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JP2002544162A |
Compounds represented by formula I:or a pharmaceutically acceptable salt or hydrate thereof, are disclosed.Pharmaceutical compositions and methods of treatment are also included.
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JP2002544255A |
The invention relates to novel substituted N-cyano amidines of general formula (I) in which: R<1> represents hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or alkyl aryl, and; R<2> represent...
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JP2002543176A |
The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, ...
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JP2002322143A |
To provide an amidine derivative effective on the treatment of diseases involving inflammation and/or allergic process, and also to provide a preparing method and a pharmaceutical composition containing the same.The amidine derivative ha...
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JP2002536354A |
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or differen...
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JP2002536432A |
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show se...
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JP2002534495A |
The invention concerns a method for preparing an azoiminoether hydrochloride which consists in reacting an azonitrile with an alcohol and hydrochloric acid in an aromatic solvent, wherein the molar ratio R=HCl/azonitrile is >2 when the a...
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JP2002534420A |
New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I,wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in the claims. The compounds of f...
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JP2002534400A |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C-NOH, or -CH(R7)- wherein R7 is hydrogen, hydroxy, C1-7alkoxy, -OR8 or -NR8R9 (wherein R8 is a group -Y1R10 (wherein Y1 is a direct bond, -C(O)-...
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JP2002534449A |
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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JP2002534408A |
The present invention is directed to new compounds for the inhibition of blood clotting proteins and factor Xa activity, and more particularly, to arylalkanoyl derivatives of the formula (I):wherein R(1), R(2), R(3), R(4), R(5), R(6a), a...
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JP3330155B2 |
PURPOSE:To provide a new hydrazone compound exhibiting excellent activity on various noxious organisms, especially lepidopterous vermin and coleopterous vermin. CONSTITUTION:The compound of formula I (R<1>, R<2> and R<4> are H, halogen, ...
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JP2002530409A |
Novel pyrimidine derivatives of formula Ias well as possible isomers and mixtures of isomers thereof.The novel compounds have plant-protective properties and are suitable for protecting plants against infestations by phytopathogenic micr...
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JP2002521476A |
This invention provides a process for preparing compounds of formula (1) wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 ca...
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JP2002521538A |
Various olefins may be polymerized using a catalyst systems containing selected alpha-diimine, urethane or urea ligands, some of them novel, complexed to nickel, palladium or other selected transition metals. The polymers are useful as m...
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JP2002193909A |
To provide new antimicrobial phenylamidine derivatives and antimicrobial compositions containing them, as well as a method for controlling fungi, comprising a step to use them.The new antimicrobial phenylamidine derivatives are antimicro...
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JP2002520384A |
(57) [Summary] The present invention relates to arylvinyl ether derivatives of general formula (I) (substituents in the formula are defined herein), compositions containing them, methods and intermediates for their production, and such. ...
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JP2002179638A |
To obtain a new bactericidal phenyl imidate derivative, to provide a method for producing the same and to obtain a bactericidal composition containing the same, as certain kind of phenyl imidate has been found to have the bactericidal ac...
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JP2002517527A |
Methods for preparing olefin polymers, and catalysts for preparing olefin polymers are disclosed. The polymers can be prepared by contacting the corresponding monomers with a Group 8-10 transition metal catalyst. The polymers are suitabl...
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JP2002515895A |
Phenoxyacetic acid derivatives of the formula:wherein R1, R2, Xn and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.
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JP2002514252A |
(57) [Summary] Disclosed are methods of making olefin polymers, oligomeric catalysts for making olefin polymers, and bidentate ligands used to make these catalysts. Polymers can be prepared by contacting the monomers with Group 8-10 tran...
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JP2002513780A |
Novel compounds of the formula Iin whichX, R1, R2, R3, R4 and R5 have the meaning indicated in Patent Claim 1,are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
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JP3278165B2 |
Compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein B is NR<5>R<11>, wherein R<5> is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl and aryl, and R<11> is selecte...
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JP2002512633A |
This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as...
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JP2002512636A |
Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
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JP2002114750A |
To provide a method for easily producing in high yield an aminobenzamidine compound as an important intermediate for pharmaceutical preparations, etc., from an inexpensive raw material.This method for producing an aminobenzamidine compou...
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JP2002511835A |
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsyc...
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JP2002105041A |
To provide a new FXa inhibitory compound excellent in absorptivity from intestinal tract, exhibiting a potent and sustaining FXa inhibitory activity and showing less adverse effect, its salts and their solvated compound.This FXa inhibito...
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JP2002510313A |
This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of fa...
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JP3269192B2 |
PURPOSE: To easily and economically prepare a 2-halogen-4,6-dialkoxy-pyrimidine derivative wherein the product is obtained with a high yield. CONSTITUTION: A propanediimidate or its salt of the formula I (R1 and R2 are each 1-4C alkyl) i...
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JP2002508313A |
Use in medicaments for the treatment of chronic obstructive pulmonary disease of compounds of formulawherein the C(=NH)-NHR3 group may be in tautomeric or isomeric form, or a pharmaceutically acceptable salt thereof, in which:R1 is amino...
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JP2002508350A |
Use of a compound of the formula (1), wherein X is an alkylene chain comprising 0, 1, 2, 3 or 4 carbon atoms; R1, R2 and R3 are independently selected from hydrogen, alkyl and aryl; R4, R5 and R6 are independently selected from hydrogen,...
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JP2002508370A |
The invention relates to novel compounds of formula (1) wherein X, Y, W, R<1>, R<2>, R<3> and R<4> have the meaning cited in Claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in prophylaxis and/or t...
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JP2002508349A |
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN-, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of ca...
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JP2002506056A |
Halogenated amidino aminoacid derivatives (I) are new. Aminoacid derivatives of formula (I) and their salts are new. [Image] R1H, alkyl, alkenyl or alkynyl; R2as R1 or R- or S-alpha -aminoacid; R3, R4as R1 or NO2; R1-R4 are optionally su...
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JP2002506099A |
The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicab...
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JP3258659B2 |
This invention relates to phenyl amidines derivatives having the following formula or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositio...
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JP2002047264A |
To provide an intermediate for synthesis of serine protease inhibitor and a method for producing the same.In order to produce a compound represented by general formula (I) [W1 is a protecting group for N-terminus; A2 represents structura...
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JP2002501942A |
The compound of the above formula wherein R1-R5 are independently selected from hydrogen, alkyl and aryl and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the compounds in therapy, particularly for treatment...
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JP2002500641A |
Substituted cyanoenamines of general formula (I) wherein Z, R<1>, R<2> and R<3> are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of dise...
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JP2001354639A |
To obtain both a preparation capable of efficiently and safely introducing a DNA into a cell and the affected part of disease and its constituent component.This compound contains plural amidino groups represented by general formula (1) o...
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JP2001526219A |
The present invention provides CLA esters and uses thereof. More particularly, the present invention provides a composition for topical use comprising CLA esters and a topical carrier. In addition, the present invention specifically prov...
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JP2001342170A |
To provide a compound having excellent pest-controlling activities.This amidine compound is represented by general formula (1) [wherein, X and Y are each a halogen atom or the like; Z is a 1-6C haloalkyl group; R1 is a halogen atom or th...
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JP3236267B2 |
To obtain the subject new compound useful as an inhibitor for blood coagulation factors and thrombin formation, or an antitumor agent. This compound is shown by formula I [E is H or OH; Q is H or an alkyl; R is a substituted aryl, a cycl...
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JP2001524999A |
(57) [Summary] Certain transition metal complexes that are useful as catalysts in the polymerization of olefin monomers are provided. Specifically, the present invention relates to certain bidentate ligands bound to Ni, Pd, Co or Fe and ...
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JP3233451B2 |
PURPOSE: To provide a compd. useful for the treatment for dermatitis diseases, tumor, atopy, psoriasis, etc., especially for keratopathy in ophthalmology. CONSTITUTION: This compd. is expressed by formula I, wherein R1 is H, -OH, -CH3, -...
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JP3232586B2 |
PURPOSE: To obtain a new organic compound having excellent insecticidal effects not only on insect pests of susceptibility group but insect pests of resistance group against organic phosphorous agent and carbamate agent. CONSTITUTION: A ...
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JP2001322974A |
To provide the subject compound as starting material in synthesizing a serine protease inhibitor, and to provide the corresponding new structural fragment in the above inhibitor.This compound itself shown by the formula or the correspond...
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JP3229408B2 |
PURPOSE: To obtain 4-amino-5-hexenoic acid useful as a medicine such 1 as a GABAT inhibitor by bringing erythritol as a starting material into successive elimination reaction, Claisen rearrangement and Oberman rearrangement. CONSTITUTION...
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