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Patent Searching and Data


Matches 1 - 50 out of 486

Document Document Title
WO/2022/164150A1
Provided are a method for efficiently producing nafamostat mesylate using a simple process, and a method for producing 6-amidino-2-naphthol mesylate, which is an intermediate of nafamostat mesylate production, at high yield and under mil...  
WO/2022/162604A1
The present invention relates to a novel cocrystal, a pharmaceutical composition comprising same and a preparation method therefor. By using the cocrystal of the present invention, cancers, inflammatory diseases, or viral infection disea...  
WO/2022/148053A1
The present invention relates to the technical field of pharmaceutical preparations, and in particular to a purification method for metformin hydrochloride, a metformin hydrochloride sustained release tablet and a preparation method ther...  
WO/2022/097813A1
The present invention relates to an eco-friendly and highly efficient method for preparing an ester compound based on an esterification reaction using a salt ion-exchange method, and an ester compound thereof. In conventional esterificat...  
WO/2022/051427A1
Described herein are compositions and methods for treating cancer in a subject. Using the compositions and methods of the disclosure, a subject may be administered (i) an inhibitor and/or an overrider and (ii) a chemotherapeutic.  
WO/2022/048909A1
The present invention concerns a modified method for preparing guanidine acetic acid (GAA) by reacting cyanamide with an excess molar amount of glycine in an aqueous reaction mixture in the presence of a base that avoids high molar amoun...  
WO/2022/048913A1
The present invention refers to a method for preparing guanidino acetic acid by reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base, wherein the ammonia content in the reaction mixture is controlled to...  
WO/2022/045163A1
The present invention provides a guanidine fatty acid salt production method through which liquid surface elevation, caused by carbon dioxide generated during production of guanidine fatty acid salt, can be suppressed. This guanidine fat...  
WO/2021/227436A1
The present invention belongs to the technical field of medicine synthesis, relates to an antifungal compound, and in particular relates to an antifungal compound, a synthesis method and the use thereof, wherein the antifungal compound i...  
WO/2021/154870A1
Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.  
WO/2021/105337A1
The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and tr...  
WO/2021/044445A1
The present invention provides a continuous solvent free and additive free process for the synthesis of Metformin Hydrochloride in a screw reactor. >90% conversion of the solid substrates without solvent is obtained in a screw reactor to...  
WO/2021/040441A1
The present invention relates to a method for preparing a biguanide-based compound with a high yield. More specifically, the present invention relates to a method for preparing a biguanide-based compound, the method comprising the steps ...  
WO/2021/012274A1
The present invention provides a preparation method for metformin hydrochloride. The preparation method comprises: heating raw materials comprising dicyandiamide and dimethylamine hydrochloride by means of microwave, and making the two r...  
WO/2021/008845A1
The invention relates to a new crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid, to crystal mixtures and to a method for producing the crystal modification and the crystal mixtures according to the invention.  
WO/2021/008844A1
The present invention relates to a novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for the production of said crystal modification.  
WO/2021/008843A1
The present invention relates to novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for producing said crystal modification.  
WO/2021/008846A1
The invention relates to a method for producing N-(aminoiminomethyl)-2-aminoethanoic acid containing N-(aminoiminomethyl)-2-aminoethanoic acid in a thermodynamically metastable crystal modification.  
WO/2021/002689A1
The present invention relates to a method for producing peramivir trihydrate, which is an inhibitor of neuraminidase infection, as an anti-influenza agent. According to the production method of the present invention, peramivir trihydrate...  
WO/2020/262455A1
The present invention provides a means for increasing the solubility of even a poorly soluble amino acid without changing to an expensive peptide and also without changing the pH, and is characterized in that at least two kinds of amino ...  
WO/2020/210252A1
A process to extract carbon from hydrophobic waste comprises: combining the hydrophobic waste with an oxide of an active metal to form a storable, moisture-resistant feedstock for high-temperature processing; heating the feedstock in a f...  
WO/2020/184797A1
The present invention relates to: an eco-friendly method capable of synthesizing an unnatural amino acid-based antibacterial and antibiotic preservative, which has excellent antibacterial and antibiotic performance, in a high yield and w...  
WO/2020/107500A1
The present invention provides a 2-(1-acyloxypentyl) benzoic acid salt formed by basic amino acid or aminoguanidine, a preparation method thereof, a pharmaceutical preparation containing the salt and the uses of the pharmaceutical prepar...  
WO/2019/154769A1
The present invention relates to an improved process for the preparation of metformin hydrochloride, an important drug in the first line treatment of Type II Diabetes.  
WO/2019/100261A1
A metformin hydrochloride synthesis system and a preparation method therefor, the synthesis system comprising a reaction apparatus (20), the reaction apparatus (20) being provided with a feed opening and a reactant discharge opening, and...  
WO/2019/092319A1
The present invention relates to a method of producing a bicyclic guanidine and its derivatives. In particular, the present invention relates to a method of producing triazabicyclodecene (TBD) and its derivatives, particularly alkyl deri...  
WO/2019/073476A1
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the...  
WO/2018/233326A1
A hydrogen sulfide donor in an organic salt form and a preparation method therefor. The hydrogen sulfide donor is a salt structure formed by organic compounds with an alkaline structure and hydrogen sulfide. The hydrogen sulfide donor ha...  
WO/2018/231843A1
A compound according to Formula (I):, wherein Z is: (II).  
WO/2018/210633A1
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.  
WO/2018/156454A1
Provided are methods of preventing or suppressing an allergic reaction to food by administering an inhibitor of the unfolded protein response (UPR) and uses of a composition comprising an inhibitor of the UPR for treating or preventing a...  
WO/2018/135977A1
The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatine - phenylcreatine, ...  
WO/2017/114226A1
Disclosed in the present invention is a method for separating and purifying a creatine mother liquor: by means of a liquor delivery tube, pumping a mother liquor after creatine synthesis to be separated in an electrodialyzer, wherein the...  
WO/2017/063155A1
The present invention provides compounds of formula I. The present invention also provides a preparation method for the compounds and a medicine composition comprising the compounds. The medicine composition can be used for treating a bo...  
WO/2017/043842A1
The present invention relates to a method for preparing D-arginine and, more particularly, to a method for preparing D-arginine by photosplitting DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as a photosplitting ag...  
WO/2017/042126A1
The invention relates to a method for producing biguanide salts of formula (III) and s-triazines of the formula (V). R1 and R2 respectively represent hydrogen, halogen and alkyl and R3 and R4 each represent hydrogen, alkyl, cycloalkyl an...  
WO/2017/036357A1
Provided are a cathepsin K inhibitor and application thereof, and specifically is a compound having a structure represented by formula (I) and being used to treat or prevent a cathepsin dependent disease. In particular, the cathepsin is ...  
WO/2017/025560A1
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the...  
WO/2016/202125A1
Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-forma midine]phenyl-2-propenamide (II), applicable in preparing AZD9291 (I) and a preparation method for the intermediate. Preparation steps comprise: ...  
WO/2016/201128A1
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also pro...  
WO/2016/180840A1
The present invention relates to the use of a catalyst of the formula (I) for the crosslinking of a curable composition. The catalyst of the formula (I) contains at least one aliphatic guanidine group. It is substantially odourless and n...  
WO/2016/110822A1
The invention relates to a novel creatine derivative, the carboxylic biacyl creatine derivative of formula (I) and pharmaceutically acceptable salts thereof, methods of synthesis and the use thereof in the treatment of pathologies due to...  
WO/2016/070712A1
Disclosed are amino acid derivatives and applications thereof. The amino acid derivatives contain the oxalyl group, and thus can interfere with energy metabolism of cells and induce apoptosis. Therefore, the amino acid derivatives can be...  
WO/2016/059507A1
The present invention provided an improved process for the preparation of Metformin compound of formula I or its pharmaceutically acceptable salts 5 thereof, by employing an alcoholic solvent throughout the process  
WO/2016/015081A9
The invention relates to a method for producing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl- or allyl-derivatives BA according to the following reaction scheme: wherein X represent...  
WO/2016/028016A1
The present invention relates to a method for preparing D-arginine, and more specifically, to a method for preparing D-arginine by light-splitting DL-arginine by using D-3-Bromocamphor-10-sulfonic acid as a light-splitting agent.  
WO/2015/168465A1
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.  
WO/2015/146882A1
By adding carbobenzoxy chloride and a basic group in a water/organic solvent bilayer system to arginine or an arginine derivative (1) which are represented by belowmentioned formula (1), or a salt of said arginine derivative (1), the arg...  
WO/2015/077500A1
The invention relates to an integrated system for the preparation of purified terephthalic acid (PTA) and the use of the PTA for the production of poly(ethylene terephthalate) (PET). Advantageously, the integrated system design described...  
WO/2015/069699A1
The present invention provides novel creatine analogs useful for treating any creatine deficiency disorders and methods of treating and preventing creatine deficiencies utilizing the present compounds and the pharmaceutical compositions ...  

Matches 1 - 50 out of 486