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Matches 1 - 50 out of 681

Document Document Title
WO/2021/044445A1
The present invention provides a continuous solvent free and additive free process for the synthesis of Metformin Hydrochloride in a screw reactor. >90% conversion of the solid substrates without solvent is obtained in a screw reactor to...  
WO/2021/040441A1
The present invention relates to a method for preparing a biguanide-based compound with a high yield. More specifically, the present invention relates to a method for preparing a biguanide-based compound, the method comprising the steps ...  
WO/2021/012274A1
The present invention provides a preparation method for metformin hydrochloride. The preparation method comprises: heating raw materials comprising dicyandiamide and dimethylamine hydrochloride by means of microwave, and making the two r...  
WO/2021/008845A1
The invention relates to a new crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid, to crystal mixtures and to a method for producing the crystal modification and the crystal mixtures according to the invention.  
WO/2021/008844A1
The present invention relates to a novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for the production of said crystal modification.  
WO/2021/008843A1
The present invention relates to novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for producing said crystal modification.  
WO/2021/008846A1
The invention relates to a method for producing N-(aminoiminomethyl)-2-aminoethanoic acid containing N-(aminoiminomethyl)-2-aminoethanoic acid in a thermodynamically metastable crystal modification.  
WO/2021/002689A1
The present invention relates to a method for producing peramivir trihydrate, which is an inhibitor of neuraminidase infection, as an anti-influenza agent. According to the production method of the present invention, peramivir trihydrate...  
WO/2020/262455A1
The present invention provides a means for increasing the solubility of even a poorly soluble amino acid without changing to an expensive peptide and also without changing the pH, and is characterized in that at least two kinds of amino ...  
WO/2020/210252A1
A process to extract carbon from hydrophobic waste comprises: combining the hydrophobic waste with an oxide of an active metal to form a storable, moisture-resistant feedstock for high-temperature processing; heating the feedstock in a f...  
WO/2020/184797A1
The present invention relates to: an eco-friendly method capable of synthesizing an unnatural amino acid-based antibacterial and antibiotic preservative, which has excellent antibacterial and antibiotic performance, in a high yield and w...  
WO/2020/107500A1
The present invention provides a 2-(1-acyloxypentyl) benzoic acid salt formed by basic amino acid or aminoguanidine, a preparation method thereof, a pharmaceutical preparation containing the salt and the uses of the pharmaceutical prepar...  
WO/2019/154769A1
The present invention relates to an improved process for the preparation of metformin hydrochloride, an important drug in the first line treatment of Type II Diabetes.  
WO/2019/100261A1
A metformin hydrochloride synthesis system and a preparation method therefor, the synthesis system comprising a reaction apparatus (20), the reaction apparatus (20) being provided with a feed opening and a reactant discharge opening, and...  
WO/2019/092319A1
The present invention relates to a method of producing a bicyclic guanidine and its derivatives. In particular, the present invention relates to a method of producing triazabicyclodecene (TBD) and its derivatives, particularly alkyl deri...  
WO/2019/073476A1
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the...  
WO/2018/233326A1
A hydrogen sulfide donor in an organic salt form and a preparation method therefor. The hydrogen sulfide donor is a salt structure formed by organic compounds with an alkaline structure and hydrogen sulfide. The hydrogen sulfide donor ha...  
WO/2018/231843A1
A compound according to Formula (I):, wherein Z is: (II).  
WO/2018/210633A1
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.  
WO/2018/156454A1
Provided are methods of preventing or suppressing an allergic reaction to food by administering an inhibitor of the unfolded protein response (UPR) and uses of a composition comprising an inhibitor of the UPR for treating or preventing a...  
WO/2018/135977A1
The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatine - phenylcreatine, ...  
WO/2017/114226A1
Disclosed in the present invention is a method for separating and purifying a creatine mother liquor: by means of a liquor delivery tube, pumping a mother liquor after creatine synthesis to be separated in an electrodialyzer, wherein the...  
WO/2017/063155A1
The present invention provides compounds of formula I. The present invention also provides a preparation method for the compounds and a medicine composition comprising the compounds. The medicine composition can be used for treating a bo...  
WO/2017/043842A1
The present invention relates to a method for preparing D-arginine and, more particularly, to a method for preparing D-arginine by photosplitting DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as a photosplitting ag...  
WO/2017/042126A1
The invention relates to a method for producing biguanide salts of formula (III) and s-triazines of the formula (V). R1 and R2 respectively represent hydrogen, halogen and alkyl and R3 and R4 each represent hydrogen, alkyl, cycloalkyl an...  
WO/2017/036357A1
Provided are a cathepsin K inhibitor and application thereof, and specifically is a compound having a structure represented by formula (I) and being used to treat or prevent a cathepsin dependent disease. In particular, the cathepsin is ...  
WO/2017/025560A1
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the...  
WO/2016/202125A1
Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-forma midine]phenyl-2-propenamide (II), applicable in preparing AZD9291 (I) and a preparation method for the intermediate. Preparation steps comprise: ...  
WO/2016/201128A1
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also pro...  
WO/2016/180840A1
The present invention relates to the use of a catalyst of the formula (I) for the crosslinking of a curable composition. The catalyst of the formula (I) contains at least one aliphatic guanidine group. It is substantially odourless and n...  
WO/2016/110822A1
The invention relates to a novel creatine derivative, the carboxylic biacyl creatine derivative of formula (I) and pharmaceutically acceptable salts thereof, methods of synthesis and the use thereof in the treatment of pathologies due to...  
WO/2016/070712A1
Disclosed are amino acid derivatives and applications thereof. The amino acid derivatives contain the oxalyl group, and thus can interfere with energy metabolism of cells and induce apoptosis. Therefore, the amino acid derivatives can be...  
WO/2016/059507A1
The present invention provided an improved process for the preparation of Metformin compound of formula I or its pharmaceutically acceptable salts 5 thereof, by employing an alcoholic solvent throughout the process  
WO/2016/034894A3
The invention provides a combination of an antibacterial agent (in particular vancomycin or moenomycin) and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the deli...  
WO/2016/015081A9
The invention relates to a method for producing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl- or allyl-derivatives BA according to the following reaction scheme: wherein X represent...  
WO/2016/028016A1
The present invention relates to a method for preparing D-arginine, and more specifically, to a method for preparing D-arginine by light-splitting DL-arginine by using D-3-Bromocamphor-10-sulfonic acid as a light-splitting agent.  
WO/2016/015081A1
The invention relates to a method for producing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl- or allyl-derivatives BA according to the following reaction scheme: wherein X represent...  
WO/2015/168465A1
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.  
WO/2015/146882A1
By adding carbobenzoxy chloride and a basic group in a water/organic solvent bilayer system to arginine or an arginine derivative (1) which are represented by belowmentioned formula (1), or a salt of said arginine derivative (1), the arg...  
WO/2015/077500A1
The invention relates to an integrated system for the preparation of purified terephthalic acid (PTA) and the use of the PTA for the production of poly(ethylene terephthalate) (PET). Advantageously, the integrated system design described...  
WO/2015/069699A1
The present invention provides novel creatine analogs useful for treating any creatine deficiency disorders and methods of treating and preventing creatine deficiencies utilizing the present compounds and the pharmaceutical compositions ...  
WO/2015/049239A1
A process for the preparation of the fluoroalkyl sulfonate salt of a nitrogen-based organic base said process comprising the step of reacting a fluoroalkyl sulfonyl halide with an organic base selected from the group consisting of tertia...  
WO/2014/204763A1
A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino ...  
WO/2014/161412A1
Disclose in the invention are a tricyclic quinolone derivative having a novel structure with a peripheral group at position C10 being substituted by non-alkaline substituents or salts and hydrates thereof. Such compounds have been proven...  
WO/2014/124796A1
The present invention relates to a two‑ply, dielectric layer for a thin‑layer capacitor, characterized in that a) the bottom, first ply (4) comprises a self‑assembled monolayer containing phosphorus oxo compounds and b) the top, se...  
WO/2014/123364A1
The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceut...  
WO/2014/121648A1
The present invention discloses a synthesis method for creatine. In a case of vacuum, carbamide and aqueous solution of sodium sarcosinate are mixed and heated. After drying, acid is added to adjust a pH value, and thermal reaction is pe...  
WO/2014/097335A1
A method of synthesizing (Boc)2-creatine derivatives of formula (III) which comprises a first step in which a sarcosine ester is reacted with a guanylating agent comprising two nitrogen atoms each protected with a t-butoxycarbonyl (t-Boc...  
WO/2014/082594A1
Provided are a compound shown in formula 1 or a purpose of a prodrug thereof in preparing medicines for treating and/or preventing infection of Tamiflu-resistant influenza virus strains. The Tamiflu-resistant influenza virus strains is p...  
WO/2014/041566A3
The present invention relates to an improved process for the preparation of Metformin hydrochloride by removing solvent from a solution comprising metformin hydrochloride using agitated thin film dryer.  

Matches 1 - 50 out of 681