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Matches 351 - 400 out of 4,271

Document Document Title
WO/2002/042243A1
Processes for preparing optically active intermediates for the synthesis of tetrahydronaphthalene derivatives useful as PGI¿2? agonist can be provided by providing a method for optical resolution of a tetrahydronaphthalene derivative of...  
WO/2002/042346A1
The invention concerns an optically active polymer obtainable by free radical or anionic polymerisation of an optically active ethylene monomer with epoxide function bearing at least a chiral centre with a copolymerisable ethylene monome...  
WO/2002/036544A1
A method of resolving optical isomers which comprises mixing in an aqueous solution an amino acid derivative in the form of a mixture of D- and L-isomers (for example, N-(tert-butoxycarbonyl)-DL-alanine) with a hydrophilic compound isome...  
WO/2002/036526A1
A method of determining the optimal yield of a target compound comprises: (a) determining the initial composition of a mixture of compounds containing the target compound; (b) dissolving the mixture in a solvent; (c) placing a quantity o...  
WO2001034599A9
This invention relates to the compound of Formula (I): or a pharmaceutically acceptable salt, hydrate or solvate thereof, which is an inhibitor of cysteine proteases, particularly cathepsin K, and is useful in the treatment of diseases i...  
WO/2002/032859A1
A process for preparing a diastereomer of a compound represented by the general formula (I) wherein the asymmetric carbon atom of R?1¿ or R?2¿ takes R- or S-configuration, or a salt thereof, characterized by resolving a mixture of dias...  
WO/2002/030919A1
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic 6,8-halo-octanoic acid with S(-)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt o...  
WO/2002/030918A2
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)$g(...  
WO/2002/030903A1
A process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydr oxy-6-heptenoate which comprises optically resolving, at a high efficiency, a mixture of optical isomers of the comp...  
WO/2002/030853A1
A packing for optical-isomer separation with which a mixture of optical isomers can be optically resolved efficiently; and a method of separating optical isomers by simulated moving-bed chromatography in which the packing is used to cond...  
WO/2002/028809A2
Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, whe...  
WO/2002/029412A2
A template (a molecule preferably of molecular size > 500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or elect...  
WO/2002/024628A1
A process for industrially advantageously producing efficiently and easily a $g(b)-amino acid derivative having a high optical purity. The process for producing an optically active $g(b)-amino acid derivative is characterized in that any...  
WO2001068729A8
Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are c...  
WO/2002/020529A1
The invention relates to a method for obtaining 4-(N-alkylamine)-5, 6-dihydro-4H-thieno-(2,3-b)-thiopyran-2-sulfamide-7, 7-dioxides (I), wherein R¿1? represents H or C¿1-5? alkyl and R¿2? represents C¿1-5? alkyl, from the correspondi...  
WO/2002/018035A2
The invention is related to a method for separating enantiomers in a supported liquid membrane module by contacting the liquid membrane (7a, 7b) which may contain a carrier and a phase transfer agent with a feed fluid (1) containing a ra...  
WO2001038292A3
The invention relates to a method for producing optically active amines. The invention also relates to a method for producing racemic amines, which can be racemically split using optically active carboxylic acids or enzymes. The inventio...  
WO/2002/015906A1
The present invention relates to a class of compounds of formula (I) and (II): wherein R¿1? is hydrogen; linear or branched C¿1?-C¿15? alkyl; C¿1?-C¿15? alkenyl; C¿3?-C¿6? cycloalkyl; mono, di, tri, tetra, penta substituted aryl o...  
WO2001085668A8
The use of the optically active forms of 5,6-dihydroxy-2-methylaminotetralin and acyl esters thereof as medicaments for cardiovascular diseases a process for the preparation thereof and their use in pharmaceutical compositions.  
WO/2002/010150A1
± 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, a process for the optical resolution thereof and their use as intermediates for the prepartion of (-) 3-(4-phenyl-1-piperazinyl)-1,2-propanediol (levodropropizine) and salts t...  
WO/2002/010096A1
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing cataly...  
WO/2002/008208A1
A process for efficient synthesis of optically active thiazolidinone derivatives of the general formula (1) which comprises optically resolving a racemic carboxylic acid of the general formula (4) by using an (S)-(-)-N-benzyl-$g(a)-pheny...  
WO2001055060A3
The invention relates to chiral ionic liquids of the general formula [A]n<+>[Y], wherein n = 1 or 2, the anion [Y] is the anion of an organic or inorganic protonic acid and the cation [A]<+> is an optically active organic ammonium cation...  
WO/2002/004384A2
A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein R¿1? represents an isopropanol group, an isopropyl group or an isopropylene group, includes the ...  
WO/2002/000601A1
An economically advantageous and industrially appropriate process for producing 3-amino-2-hydroxypropionic acid derivatives (1) without resort to any dangerous reagents characterized by comprising treating an N-protected-3-amino-2-hdyrox...  
WO/2001/098265A2
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO/2001/098370A1
A novel conjugate of a support material and an oligomer or polymer of a saccharide that is linked to the support material via urea linkages, and in which the oligomers or polymers are cross-linked via urea linkages provides a valuable st...  
WO2000023414A3
A process for the preparation of optically active cyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or oth...  
WO/2001/094333A2
Disclosed are processes for coupling amino substituted 2-chromanyl derivatives and benzoyl derivatives via an amide bond, and intermediates for producing platelet aggregation inhibitors and for producing potent platelet aggregation inhib...  
WO2001019761A3
One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the pre...  
WO2001032691A8
Compounds of formula (I) and pharmaceutically acceptable salts and esters thereof are active as inhibitors of hepatitis C virus NS3 protease. Consequently they are potentially useful in the treatment and prevention of hepatitis C virus i...  
WO/2001/085668A1
The use of the optically active forms of 5,6-dihydroxy-2-methylaminotetralin and acyl esters thereof as medicaments for cardiovascular diseases a process for the preparation thereof and their use in pharmaceutical compositions.  
WO2000017133A3
The invention concerns LTA4 hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.  
WO/2001/083422A1
A process for separating a mixture of trans (RR, SS) and cis (RS, SR) tramadol comprises a classical salt resolution using a chiral resolving agent selected from tartaric acid and derivatives thereof, and mandelic acid, provided that the...  
WO/2001/079174A1
The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-c arboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-o xide-3-carboxamidine and (S)-(+)-N-[2-h...  
WO/2001/068729A1
Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are c...  
WO/2001/068566A1
The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1...  
WO/2001/068637A2
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO/2001/062257A2
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective ...  
WO/2001/062712A1
The present invention relates to (2S)-enantiomers of 2-aminoindan derivatives of formula (I), and a novel process for the preparation of them.  
WO/2001/058588A1
Ferrocene anchored chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such...  
WO/2001/058835A1
The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially fea...  
WO/2001/055060A2
The invention relates to chiral ionic liquids of the general formula [A]¿n??+¿[Y]?n-¿, wherein n = 1 or 2, the anion [Y]?n-¿ is the anion of an organic or inorganic protonic acid and the cation [A]?+¿ is an optically active organic ...  
WO/2001/055095A1
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...  
WO/2001/051453A1
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed wh...  
WO/2001/042190A1
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegene...  
WO/2001/039884A2
A chiral catalyst comprising a 3,4-disubstituted pyridine, or a salt, N functionalised derivative, dimer or oligomer thereof, wherein the 3-substituent is substantially hindered from rotation about the bond (sp?2¿-sp?2¿ biaryl axis) li...  
WO/2001/040159A1
The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the ...  
WO/2001/038292A2
The invention relates to a method for producing optically active amines. The invention also relates to a method for producing racemic amines, which can be racemically split using optically active carboxylic acids or enzymes. The inventio...  
WO2000032555A8
Methods of preparing and compositions comprising, derivatives of (+)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depre...  

Matches 351 - 400 out of 4,271