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WO/2013/061515A1 |
[Problem] The present invention provides: a composition for imparting a cooling sensation, which contains 3-menthoxy propanol; and a method for producing 3-menthoxy propanol with high selectivity and high yield using 3-menthoxy-1,2-epoxy...
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WO/2013/058241A1 |
The present invention makes it possible to produce (R)-2-amino-2-ethylhexanol, which is useful as a pharmaceutical intermediate, easily and efficiently without complicated procedures. (R)-2-amino-2-ethylhexanol is produced by asymmetrica...
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WO/2013/043009A2 |
Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in a high purity and a high yield without purification by column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in a high purity and a...
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WO/2013/010618A1 |
The invention relates to a method for producing optically pure propane-1,2-diol, comprising the method steps: a. hydrogenation of lactides, metal-catalysed heterogenous catalysis being carried out in the presence of hydrogen, a crude pro...
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WO/2012/169575A1 |
A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting ...
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WO/2012/165499A1 |
In order to provide a compound exhibiting a high controlling effect with respect to a plant disease, this triazole compound is the compound indicated in formula (I), the -OH group, the -R2 group, and the CH2-Ar group bonded to the cyclop...
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WO/2012/158099A1 |
The present invention is directed to a process for the preparation of benzyl [(3a S,4R,6S,6a R)-6-hydroxy-2,2-dimethyltetrahydro-3a H-cyclopenta[d][1,3]dioxol-4- yl]carbamate (VI), (VI), to products of said process and the use thereof.
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WO/2012/153991A2 |
The present invention relates to a method for preparing chiral α-aminonitrile through a strecker reaction by using a cyanide source under a catalyst having Chemical Formula 1 or Chemical Formula 2 of ethylene glycol derivatives. Accordi...
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WO/2012/152779A1 |
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separat...
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WO/2012/147020A1 |
A process for the preparation and purification of Frovatriptan of formula (I) and its enantiomers, particuariy the R- enantiomer is disclosed, comprising formation of the di-p-toluoyltartaric acid salt of Frovatriptan.
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WO/2012/142983A1 |
Diastereomeric salts of the compound of formula I with D-(-)-mandelic and R-(-)-3- chloromandelic acid, a method of for the preparation thereof and their use in the synthesis of the drug ticagrelor.
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WO/2012/137047A1 |
The present invention relates to an improved process for the preparation of Fesoterodine and pharmaceutically acceptable salts thereof. The present invention particularly relates to a process for the preparation of fesoterodine and pharm...
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WO/2012/121068A1 |
In this method of producing optically active 1-amino-2-vinylcyclopropane carboxylic acid ester, a 1-amino-2-vinylcyclopropane carboxylic acid ester and an optically active tartaric acid or an optically active camphorsulfonic acid are rea...
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WO/2012/116752A1 |
A process for resolution of a mixture of (R)-and (S)-enantiomers of 1-aminoindan comprising fractional crystallizing one diastereomeric acid addition salt of 1-aminoindan from a solution containing a pair of diastereomeric acid addition ...
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WO/2012/072663A9 |
The present invention relates to a new process of separation of triazine derivatives enantiomers involving tartaric acid.
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WO/2012/093165A1 |
The present invention relates to resolution methods for manufacture of 4-((1R,3S)-6- chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3- phenyl-indan-1-yl)-3,3-dimethyl-piperazine and pharmaceutically accept...
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WO/2012/081885A2 |
The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate f...
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WO/2012/070896A2 |
The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 r...
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WO/2012/059797A1 |
Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of (RS) - 3-cyano-5-methyl-hexanoic acid thr...
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WO/2012/033187A1 |
The present invention pertains to a method for producing optically active 2-aminobutyric acid containing a step for obtaining a diastereometric salt of optically active 2-aminobutyric acid and optically active tartaric acid by combining ...
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WO/2012/033188A1 |
A method for producing an optically active amino acid, said method comprising heating an amino acid and an optically active carboxylic acid together with an aldehyde in an organic solvent, and then adding an amine to the organic solvent ...
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WO/2012/001571A1 |
The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Di...
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WO/2012/000308A1 |
A method for resolution of tetrabenazine is disclosed. Racemic tetrabenazine is used as starting material and salified with D- or L-chiral acid to form the corresponding tetrabenazine enantiomer chiral acid salt according to dissolubilit...
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WO/2011/158720A1 |
Disclosed is a method for efficiently producing a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate, at low cost. Specifically, a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxyli...
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WO/2011/129365A1 |
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition m...
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WO/2011/124934A1 |
Process for the preparation of (S)-(+)-pregabalin (1) that racemic pregabalin (2) was solved in water, reacted with a chiral a-hydroxy-carboxylic acid or a mixture of chiral α-hydroxy-carboxylic acids in desired case in the presence of ...
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WO/2011/102388A1 |
Provided is a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
which is useful as an intermediate for synthesizing a therapeutic agent for hepatitis C, and also provided is a novel method for produ...
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WO/2011/086566A1 |
Novel method for synthesis of optically pure (S)-(-)-1,1'-bi-2-naphthol and/or (R)-(+)-1,1'-bi-2-naphthol via resolution of racemic (RS)-1,1'-bi-2-naphthol through formation of co-crystal with optically active derivatives of γ -amino ac...
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WO/2011/078172A1 |
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...
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WO/2011/073300A1 |
The present invention relates to a process for the resolution of two enantiomers which consists in inducing the preferential crystallization of one enantiomer by adjusting the composition of a suspension or solution including a racemic m...
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WO/2011/070028A1 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
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WO/2011/061934A1 |
The disclosed method for producing a bicyclo [3.1.0] hexane represented by formula I or a salt thereof contains: a step for causing oxygen to act on a non-optically-active compound represented by formula II causing an asymmetric acylatio...
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WO/2011/049155A1 |
Disclosed is a process for producing cis-QMF, which has low environmental burden and is industrially advantageous. Specifically disclosed is a process for producing a cis-type 2-alkylspiro(1,3-oxathiolan-5,3')quinuclidine hydrochloric ac...
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WO/2011/026830A1 |
The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit (10) and in at least one second crystallization ...
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WO/2011/026318A1 |
The chiral compound S-5-substituent-N-2'-(thiophene-2-yl)ethyl-tetralin-2-amine or chiral acid salts and preparation method thereof are disclosed, and the method of preparing rotigotine by using the chiral compound is also disclosed. Rac...
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WO/2011/024718A1 |
Disclosed is a novel separating agent for optical isomers, which is composed of a polymer having an optically active moiety. Specifically disclosed is a separating agent for optical isomers, which is composed of a helical polymer that co...
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WO/2011/024691A1 |
A process for the preparation of optically active ethyl 1-amino-2-ethenylcyclopropanecarboxylate represented by formula (3), an enantiomer thereof, or acid addition salts of the same, which comprises a step of reacting a mixture containi...
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WO/2011/010579A1 |
Disclosed is a process for producing optically active nipecotamide, which comprises the steps of: reacting nipecotamide with optically active lactic acid in a solvent to prepare a diastereomer salt mixture and causing one of diastereomer...
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WO/2011/004778A1 |
Disclosed is a method for producing a compound represented by formula (3) or a salt thereof, comprising a step of reacting an optical isomer mixture of a compound represented by formula (1) with optically active mandelic acid in a solven...
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WO/2010/143409A1 |
Disclosed are: a process for producing a salt of an optically active thiazolylalanine derivative which has a desired configuration by converting a thiazolylalanine derivative into a salt thereof and crystallizing a compound having one of...
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WO/2010/128517A1 |
The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-rital...
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WO/2010/120138A2 |
The present invention relates to a salicylaldehyde chiral compound (chemical formula 1) and a naphtholaldehyde chiral compound (chemical formula 2), wherein a –OH group and a carbonyl group are adjacent to each other on a benzene ring....
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WO2010110361A1 |
Disclosed is a method for producing a compound which has an excellent activity as an a2d ligand. Specifically disclosed is a method for producing a compound represented by general formula (I) or a salt thereof through optical resolution....
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WO2010110555A2 |
The present invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. The method of the present invention significantly shortens the time taken for optical transformation...
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WO/2010/104034A1 |
Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a car...
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WO/2010/067824A1 |
A process for industrially producing an intermediate for a compound that shows an inhibitory action on an activated blood coagulation factor X and that is useful as a preventive and/or therapeutic agent for thrombotic diseases has been d...
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WO/2010/050499A1 |
Provided is a simple and easy process for the production of an optically active organic carboxylic acid. The simple and easy process comprises: either adding a specific amount of an alkali to an optically active enantiomer mixture which...
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WO/2010/029950A1 |
Disclosed are: a process for producing an optically active epoxy compound and an optically active sulfoxide compound; a ligand and a complex for use in the process; and a process for producing the complex. Specifically disclosed are: an ...
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WO/2010/025968A2 |
Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, i...
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WO/2010/020719A1 |
The present invention relates to the compound of formula (I) and to the use thereof as an intermediate for the synthesis of the compound of formula (A) or pharmaceutically acceptable salts thereof: formulae (II).
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