Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 101 - 150 out of 4,263

Document Document Title
WO/2011/129365A1
Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition m...  
WO/2011/124934A1
Process for the preparation of (S)-(+)-pregabalin (1) that racemic pregabalin (2) was solved in water, reacted with a chiral a-hydroxy-carboxylic acid or a mixture of chiral α-hydroxy-carboxylic acids in desired case in the presence of ...  
WO/2011/102388A1
Provided is a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as an intermediate for synthesizing a therapeutic agent for hepatitis C, and also provided is a novel method for produ...  
WO/2011/086566A1
Novel method for synthesis of optically pure (S)-(-)-1,1'-bi-2-naphthol and/or (R)-(+)-1,1'-bi-2-naphthol via resolution of racemic (RS)-1,1'-bi-2-naphthol through formation of co-crystal with optically active derivatives of γ -amino ac...  
WO/2011/078172A1
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...  
WO/2011/073300A1
The present invention relates to a process for the resolution of two enantiomers which consists in inducing the preferential crystallization of one enantiomer by adjusting the composition of a suspension or solution including a racemic m...  
WO/2011/070028A1
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...  
WO/2011/061934A1
The disclosed method for producing a bicyclo [3.1.0] hexane represented by formula I or a salt thereof contains: a step for causing oxygen to act on a non-optically-active compound represented by formula II causing an asymmetric acylatio...  
WO/2011/049155A1
Disclosed is a process for producing cis-QMF, which has low environmental burden and is industrially advantageous. Specifically disclosed is a process for producing a cis-type 2-alkylspiro(1,3-oxathiolan-5,3')quinuclidine hydrochloric ac...  
WO/2011/010284A3
The present invention relates to the development of new chiral stationary phases (CSPs), named chiral xanthone stationary phases (CXSPs), and to the use thereof for the enantiomeric resolution by high-performance liquid chromatography (H...  
WO/2011/026830A1
The invention concerns a method for separating a racemic compound-forming chiral substance by a cyclic crystallization process which is conducted in at least one first crystallization unit (10) and in at least one second crystallization ...  
WO/2011/026318A1
The chiral compound S-5-substituent-N-2'-(thiophene-2-yl)ethyl-tetralin-2-amine or chiral acid salts and preparation method thereof are disclosed, and the method of preparing rotigotine by using the chiral compound is also disclosed. Rac...  
WO/2011/024718A1
Disclosed is a novel separating agent for optical isomers, which is composed of a polymer having an optically active moiety. Specifically disclosed is a separating agent for optical isomers, which is composed of a helical polymer that co...  
WO/2011/024691A1
A process for the preparation of optically active ethyl 1-amino-2-ethenylcyclopropanecarboxylate represented by formula (3), an enantiomer thereof, or acid addition salts of the same, which comprises a step of reacting a mixture containi...  
WO/2011/010579A1
Disclosed is a process for producing optically active nipecotamide, which comprises the steps of: reacting nipecotamide with optically active lactic acid in a solvent to prepare a diastereomer salt mixture and causing one of diastereomer...  
WO/2010/120138A3
The present invention relates to a salicylaldehyde chiral compound (chemical formula 1) and a naphtholaldehyde chiral compound (chemical formula 2), wherein a –OH group and a carbonyl group are adjacent to each other on a benzene ring....  
WO/2011/004778A1
Disclosed is a method for producing a compound represented by formula (3) or a salt thereof, comprising a step of reacting an optical isomer mixture of a compound represented by formula (1) with optically active mandelic acid in a solven...  
WO/2010/143409A1
Disclosed are: a process for producing a salt of an optically active thiazolylalanine derivative which has a desired configuration by converting a thiazolylalanine derivative into a salt thereof and crystallizing a compound having one of...  
WO/2010/110555A3
The present invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. The method of the present invention significantly shortens the time taken for optical transformation...  
WO/2010/128517A1
The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-rital...  
WO/2010/120138A2
The present invention relates to a salicylaldehyde chiral compound (chemical formula 1) and a naphtholaldehyde chiral compound (chemical formula 2), wherein a –OH group and a carbonyl group are adjacent to each other on a benzene ring....  
WO2010110361A1
Disclosed is a method for producing a compound which has an excellent activity as an a2d ligand. Specifically disclosed is a method for producing a compound represented by general formula (I) or a salt thereof through optical resolution....  
WO2010110555A2
The present invention relates to a method for obtaining optically pure amino acids, including optical resolution and optical conversion. The method of the present invention significantly shortens the time taken for optical transformation...  
WO/2010/104034A1
Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a car...  
WO/2010/012746A3
The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R)...  
WO/2010/067824A1
A process for industrially producing an intermediate for a compound that shows an inhibitory action on an activated blood coagulation factor X and that is useful as a preventive and/or therapeutic agent for thrombotic diseases has been d...  
WO/2010/025968A3
Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, i...  
WO/2009/151733A3
A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and pol...  
WO/2010/050499A1
Provided is a simple and easy process for the production of an optically active organic carboxylic acid. The simple and easy process comprises: either adding a specific amount of an alkali to an optically active enantiomer mixture which...  
WO/2010/029950A1
Disclosed are: a process for producing an optically active epoxy compound and an optically active sulfoxide compound; a ligand and a complex for use in the process; and a process for producing the complex. Specifically disclosed are: an ...  
WO/2010/025968A2
Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, i...  
WO/2010/020719A1
The present invention relates to the compound of formula (I) and to the use thereof as an intermediate for the synthesis of the compound of formula (A) or pharmaceutically acceptable salts thereof: formulae (II).  
WO/2010/012746A2
The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R)...  
WO/2010/009630A1
Disclosed is a process for preparing chiral pharmaceutical intermediates of R-beta-amino phenylbutyric acid derivatives (I) and the pharmaceutically acceptable salts thereof, which affords the desired object compounds having specific opt...  
WO/2010/000634A1
The present invention relates to a process for the isomerization of the Z-isomer I-Z of a semicarbazone compound of the general formula (I) into its E-isomer I-E wherein the variables in formula (I) have the meanings as defined in the de...  
WO/2010/001103A1
There is described a process for the manufacture of a racemic 2-aryl propionic acid compound, or a pharmaceutically acceptable salt thereof, which comprises reacting the S- or R- enantiomer of the corresponding 2-aryl propionic acid comp...  
WO/2009/142194A1
Disclosed is a production method which enables mass synthesis of an aminoalcohol derivative with high optical purity at low cost. For example, a compound represented by the general formula is recrystallized during the production procedur...  
WO/2009/137853A1
An enantioselective zwitterionic ion-exchange material comprising a chiral selector component (SO) comprising at least one cation exchange group and at least one anion exchange group and a carrier, carrying said selector component, where...  
WO/2009/134737A1
A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.  
WO/2009/094569A3
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.  
WO/2009/119700A1
Provided is a manufacturing method for a piperidine-3-ylcarbamate compound in which a pyridine-3-ylcarbamate compound and hydrogen are brought into contact in the presence of a palladium catalyst.  
WO/2009/113428A1
Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically ...  
WO/2009/107571A1
Disclosed is a method for optical resolution of an alkylpiperidin-3-yl carbamate, wherein an RS mixture of an alkylpiperidin-3-yl carbamate is brought into contact with an optically active tartaric acid in the presence of a solvent.  
WO/2009/025791A3
The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)d...  
WO/2009/098935A1
Disclosed is a method for purifying an optically active 1-(2-trifluoromethylphenyl)ethanol, which includes recrystallization of an optically active 1-(2-trifluoromethylphenyl)ethanol represented by formula [1] (wherein * represents an as...  
WO/2009/094569A2
Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.  
WO/2009/090957A1
Optically active organosulfonic acid salts of optically active [4-(2-diphenylphosphanylnaphthalen-1-yl)phthalazin-1-yl]-(1- phenylethyl)amines represented by formula (1) to (4); and a process for production of the same.  
WO/2009/087959A1
Disclosed are an optically active 2,2'-biphenol derivative and a method which enables simple and efficient production of the compound. Specifically disclosed are an optically active biphenol derivative represented by Formula (1) or (2); ...  
WO/2009/080708A1
Use of enantiopure N-sulphonyl pyroglutamic acid as resolving agent for the separation of enantiomers by crystallization or precipitation.  
WO/2009/075359A1
It is intended to achieve a method of separating isomers of chiral substances which is non-contact and does not use a chemical reaction by irradiating chiral substances C with light such as circular polarized light and separating isomers...  

Matches 101 - 150 out of 4,263