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Matches 301 - 350 out of 4,325

Document Document Title
WO2002092562A3
The present invention provides multiphasic systems comprising at least one chiral selector and an achiral phase transfer catalyst, wherein said system can be used to effect enantioselective reactions or asymmetric induction reactions.  
WO/2003/062225A1
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by R...  
WO/2003/062203A1
A novel process for preparing 3−[(4S)−5−oxo−2−(trifluoromethyl)−1,4,5,6,7,8− hexahydroquinolin−4−yl]benzonitrile, pharmaceutical compositions containing the compound and methods of treatment using the same.  
WO/2003/059846A1
The present invention provides the use of highly homogeneous serum albumin as a chiral selector, preferably immobilised, such as in enantioselective chromatography. The present invention also provides an enantioselective chromatography c...  
WO/2003/059512A1
The invention concerns a catalyst immobilized on silica for heterogeneous catalysis, in the form of silica particles of average grain size distribution ranging between 15 $g(m)m and 2 mm comprising a ligand bound to the particles by a co...  
WO/2003/055831A1
Process for modifying the relative ratios of the components of a liquid starting mixture of specific diastereoisomers, containing at least two asymmetric carbon atoms comprising contacting said liquid mixture with a Lewis acid compound c...  
WO/2003/051852A1
An intermediate represented by the general formula (I): (I) (wherein R1 represents propyl, 2−propenyl, or 2−propinyl and R2 represents C4−8 alkyl)&semi a process for producing the intermediate&semi and a process for producing from ...  
WO/2003/051861A1
The invention relates to a method for the preparation of escitalopram by cyanation of optically active intermediates of the formulas (III) and (II) below, and the preparation of such intermediates by optical resolution.  
WO/2003/050062A2
Methods for production of chirally pure $g(a)-amino acids and N-sulfonyl $g(a)-amino acids are described. An aldehyde and a cyanide salt are reacted with an $g(a)-methylbenzylamine to afford a product. The product reacts with a strong ac...  
WO/2003/048080A1
Methods for the separation of chaotropic and kosmotropic enantiomers within a racemic mixture are provided. Such methods comprise differentially partitioning the enantiomers into stabilized microdomains of low density water and high dens...  
WO2002088149A3
The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the des...  
WO/2003/041702A1
The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate and medicaments containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate as active ingredient for the treatment of ge...  
WO/2003/042132A1
A process for the recovery of substituted tartaric acid resolving agents from resolution process liquors comprising organic solvents, wherein the substituted tartaric acid derivatives are neutralised by adding a base, extracted into an a...  
WO2002100804A3
The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R1, R2) N-SO3H, wherein: R1 and R2, being the same or different, represent a hydrogen atom or a C1-C30 linear, branched ...  
WO/2003/037840A1
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, a...  
WO/2003/022784A1
The invention relates to a method for determining the enantiomer ratio of trimethylcyclopentene derivatives of structure (I), wherein Z is an alkyl radical having 1 - 10 C atoms, can be saturated or olefinically unsaturated, straight-cha...  
WO/2003/016245A1
The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is perf...  
WO/2003/011842A1
This invention relates to novel indane acetic acid derivatives of formula (I) which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermedia...  
WO/2003/011846A2
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5 -isobenzofurancarbaldoxime, O-substitute...  
WO/2003/011799A1
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing cataly...  
WO/2003/011802A1
The invention relates to the compound (1S/R)-1-[(1S/R)-1,5-dimethyl-hex-5-enyl]-4-methyl-cyclohex- 3-en-1-ol(iso-$g(b)-bisabolol) of formula A and to its individual configuration isomers. Iso-$g(b)-bisabolol has a very strong flowery, li...  
WO2002029412A3
A template (a molecule preferably of molecular size > 500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or elect...  
WO/2003/003804A2
The invention relates to a process for the preparation of (R, R)-phenylisoserine and its derivatives. The process according to the invention includes the following steps : - reacting a 3-phenylglycidic acid salt with ammonia to yield the...  
WO2002076930A3
Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and...  
WO2001068637A3
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...  
WO/2003/000636A1
The subject of the present invention is the preparation of the (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racemic compound by using the compounds of the general formula (II).  
WO/2003/000672A1
The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-ci...  
WO/2002/103349A1
A separatory agent for optical isomers which has the high optical resolving ability inherent in polysaccharide derivatives, has solvent resistance, and has high solubility in a reaction solvent and satisfactory filterability, i.e., is ad...  
WO2001079174A8
The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-c arboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-o xide-3-carboxamidine and (S)-(+)-N-[2-h...  
WO2002059128A3
The present invention discloses a process for the preparation of thieno[3,2-c]pyridine derivatives of general formula (I), in either racemic or optically active (+) or (-) forms and their salts, wherein X, the substituent on benzene ring...  
WO/2002/100804A2
The invention relates to the use of chiral sulfamic acids as resolving agents, the sulfamic acid having the formula (R¿1?, R¿2?) N-SO¿3H?, wherein: R¿1? and R¿2?, being the same or different, represent a hydrogen atom or a C¿1-?C¿...  
WO/2002/098923A1
The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or partially esterified with alcohols or are in...  
WO/2002/096909A1
A method for resolving enantiomers of a compound containing the structure of the formula (I): wherein R?4¿ or R?5¿ may contain one or more asymmetric centers, by mixing a racemic mixture of enantiomers of a compound, containing the str...  
WO/2002/094801A1
The invention relates to a method for producing biperiden which is characterised in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-l-propanone is reacted with an isomer ratio of the exo form to the endo form of...  
WO/2002/092562A2
The present invention provides multiphasic systems comprising at least one chiral selector and an achiral phase transfer catalyst, wherein said system can be used to effect enantioselective reactions or asymmetric induction reactions.  
WO/2002/088048A1
A separatory agent for optical isomers which has the excellent ability to identify asymmetry. It comprises as the active ingredient a polysaccharide derivative having a structure made up of two or more rings comprising an aromatic, aliph...  
WO/2002/088049A1
A separatory agent for optical isomers which has the characteristic ability to identify asymmetry. It comprises as the active ingredient an aromatic polysaccharide derivative having a C¿10? or higher alkoxy group as a substituent for an...  
WO/2002/088149A2
The present invention discloses a process for the synthesis of fosinopril as a single desired isomer of high purity in two steps comprising of (a) preparation of fosinopril as a mixture of four diastereomers and (b) separation of the des...  
WO/2002/085836A1
A binaphtol derivative represented by the following general formula [1]: [1] and a salt of the derivative.  
WO2001098265B1
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO/2002/076930A2
Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and...  
WO1998008787A3
Described herein is a novel process to resolve a racemic compound into its optically active isomers without need for chemical transformation such as salt formation. The process advantageously utilizes polymers containing chiral moieties ...  
WO/2002/072514A1
This invention provides methods and catalysts systems for catalyzing enantioselective oxidation reactions, including cyclization reactions and enantioselective oxidation reactions of secondary alcohols and other similarly reactive organi...  
WO/2002/070123A1
A separating agent for an optical isomer which comprises an alicyclic ester derivative or a polysaccharide having no aromatic group as an effective component. The separating agent has no great UV absorption as demonstrated by that by an ...  
WO/2002/068404A1
The invention relates to a novel method for producing optically active dihydropyrones, novel intermediate products obtained by said synthesis, and the use of the same as parent compounds in the production of pharmaceutically active compo...  
WO2002044177A3
The invention provides a process for the optical resolution of a racemic mixture, or an otpionally enriched mixture, of trans-7-(hydromethyl)octa-hydro-2H-pyrido-1,2a)pyrazine, a key intermediate for preparing pharmacologically active 2,...  
WO2001098265A3
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO2002044142A3
Novel piperazine derivatives are provided having the formula (III) wherein R>1< is cyano, notro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT>1A< receptor antagonists.  
WO/2002/059128A2
The present invention discloses a process for the preparation of thieno[3,2-c]pyridine derivatives of general formula (I), in either racemic or optically active (+) or (-) forms and their salts, wherein X, the substituent on benzene ring...  
WO2002030918A3
Process for the synthesis of R(+) alpha -lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+) alpha -methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+...  

Matches 301 - 350 out of 4,325