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WO/2008/102920A1 |
Disclosed is an optical isomer separating filler having separation performance/separation characteristics different from those of conventional optical isomer separating fillers, which is capable of separating an optical isomer which cann...
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WO/2008/102720A1 |
The invention is directed to a method for producing optically active 3-aminopiperidine or a salt thereof, in which racemic nipecotamide is converted into optically active nipecotamide and optically active nipecotic acid by stereoselectiv...
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WO/2008/102671A1 |
Disclosed is a method for easily isolating/purifying and separating/removing (2S,3R,4S)-4-hydroxyisoleucine with high purity and high yield. Specifically disclosed is a method for purifying (2S,3R,4S)-4-hydroxyisoleucine or a chemically ...
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2008/072773A1 |
Disclosed is a production method comprising the steps (A)-(E) below, which enables to commercially and safely produce (1R,2R)-2-amino-1-cyclopentanol or a hydrochloride thereof.
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WO/2008/070909A1 |
The present invention relates to a process for obtaining the R-enantiomer of salbutamol from a mixture of the enantiomers of salbutamol by a crystallization of said R-enantiomer as its salt with R-ibuprofen from a solution or slurry of a...
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WO/2008/053652A1 |
A process for producing 1-hydroxy-4-aminoadamantane shown below. wherein R1 and R2 independently represent a hydrogen, a halogen, a carboxy, a nitro, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylsulfonyl...
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WO/2008/038300A8 |
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2- phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1 '-binaphthalene (BINO...
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WO/2008/038300A1 |
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2- phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1 '-binaphthalene (BINO...
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WO/2008/029785A1 |
Disclosed is a polysaccharide derivative containing a structure wherein hydrogen atoms in a hydroxy group or amino group at the 2-position and the 3-position of a structural unit of polysaccharide are substituted with different substitue...
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WO/2008/019055A3 |
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.
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WO/2008/019055A2 |
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.
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WO/2008/015689A1 |
A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate...
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WO/2008/012047A1 |
The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
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WO2007092264B1 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO2007060412A8 |
Method and apparatus for temperature controlled processes in a vessel to provide improved process control, in particular to enable controlled temperatures to be applied to a substance in different process zones of a vessel, has a series ...
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WO/2007/111706A2 |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof.
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WO/2007/111706A3 |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof.
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WO/2007/105729A1 |
Disclosed are: a process for production of 3-amino-2-hydroxyhexanoic acid cyclopropylamide with high efficiency, which is suitable for the production in an industrial scale; an intermediate compound useful for the process; and a process ...
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WO/2007/103221A2 |
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...
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WO/2007/103221A3 |
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...
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WO/2007/097336A1 |
A process by which (2R,3R)- and (2S,3S)-3-phenylisoserine derivatives useful as an intermediate for medicines can be easily and industrially advantageously produced. A salt of (2R,3S)- or (2S,3R)-3-phenylglycidic acid is reacted with amm...
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WO/2007/093764A1 |
The present invention relates to a process for the cyanation of imines, particularly to the asymmetric cyanation of imines. The Strecker reaction consists of a reaction between an aldehyde and an amine to form an imine, followed by the c...
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WO/2007/092264A2 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO/2007/092264A3 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO/2007/088571A2 |
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiome...
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WO/2007/088571A3 |
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiome...
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WO/2007/075609A2 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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WO/2007/075609A3 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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WO/2007/075608A1 |
A chiral particulate material and method of making the same are provided. The material includes a fibrous protein or chiral synthetic polymer, optionally crosslinked, organized into a multilayered chiral structure including nanoscale chi...
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WO2007023129B1 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/069745A1 |
Disclosed is a method for producing an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid, a basic amino acid salt thereof or an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester with high yield and high optical ...
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WO/2007/066160A1 |
The subject of the present invention is the separation of the optical isomers of the racemic hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-
2-one (“Corey-lactone”) of formula (I), by liquid chromatography. The laevo-rot...
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WO/2007/060412A1 |
Method and apparatus for temperature controlled processes in a vessel to provide improved process control, in particular to enable controlled temperatures to be applied to a substance in different process zones of a vessel, has a series ...
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WO/2007/043407A1 |
A fluorobenzaldehyde is reacted with an alkyl Grignard reagent to convert them into a magnesium alkoxide of a racemic fluorobenzyl alcohol. Subsequently, the magnesium alkoxide is reacted with phthalic anhydride to obtain a half ester of...
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WO/2007/041571A1 |
An improved method of making amphetamine free base.
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WO/2007/038277A3 |
The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: (I) from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
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WO/2007/036570A1 |
The present invention relates to a method for fractionating stereoisomeric compounds which have at least one alcohol group and/or amino group, by distillative separation in the presence of a chiral discriminator which takes the form of a...
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WO/2007/023056A1 |
The present invention relates to a process for the organo- catalysed kinetic racemate resolution of compounds of the general formula (II). It is thus possible through the action of catalytic amounts of enantiomerically enriched compounds...
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WO/2007/023129A2 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/023129A3 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/017424A1 |
A method for the determination of the enantiomeric composition of a chiral compound comprising : a) derivatising said chiral compound with a enantiomerically and diastereomerically pure compound of general formula (I) and b) analysing th...
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WO/2007/007828A1 |
Disclosed is a novel compound useful as a production intermediate for benzylamine derivatives. Also disclosed is a method for producing such a compound. Specifically disclosed is a method for producing an ethylenediamine derivative repre...
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WO/2007/004077A2 |
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite solvent to obtain tamsulosin. Optically p...
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WO/2007/004077A3 |
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite solvent to obtain tamsulosin. Optically p...
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WO/2007/000918A1 |
Benzylamine derivatives having structures represented by the general formula (1): (1) a method for the optical resolution of benzylamine derivatives which comprises using optically active mandelic acid as the reagent for optical resoluti...
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WO/2006/136866A1 |
The present invention relates to a process for optically resolving eszopiclone, comprising chiral chromatography. Preferably the process comprises a multi-column continuous process or a simulated moving bed process. Preferably the statio...
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WO/2006/099926A1 |
A process for preparing enantiopure E-(2S)-alkyl-5-halopent-4-enoic acids and their esters of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-C4-alkyl and X is chlorine, bromine or iodine, in which the corresponding r...
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WO2006058681A3 |
The invention relates to a method for producing enantiomer-enriched lactones by carbonylating lactones into anhydrides in the presence of a catalyst system, containing: A) at least one carbonylation catalyst A comprised of neutral or ani...
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WO/2006/087556A1 |
A process for separating enantiomers or isomers present in a liquid phase through formation and then subsequent decomposition of a host-guest complex coupled to membrane nanofiltration, comprising the steps of: (a) providing a first solu...
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