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WO/2007/075609A2 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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WO/2007/075608A1 |
A chiral particulate material and method of making the same are provided. The material includes a fibrous protein or chiral synthetic polymer, optionally crosslinked, organized into a multilayered chiral structure including nanoscale chi...
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WO/2007/075609A3 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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WO2007023129B1 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/069745A1 |
Disclosed is a method for producing an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid, a basic amino acid salt thereof or an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester with high yield and high optical ...
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WO/2007/066160A1 |
The subject of the present invention is the separation of the optical isomers of the racemic hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-
2-one (“Corey-lactone”) of formula (I), by liquid chromatography. The laevo-rot...
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WO/2007/060412A1 |
Method and apparatus for temperature controlled processes in a vessel to provide improved process control, in particular to enable controlled temperatures to be applied to a substance in different process zones of a vessel, has a series ...
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WO/2007/043407A1 |
A fluorobenzaldehyde is reacted with an alkyl Grignard reagent to convert them into a magnesium alkoxide of a racemic fluorobenzyl alcohol. Subsequently, the magnesium alkoxide is reacted with phthalic anhydride to obtain a half ester of...
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WO/2007/041571A1 |
An improved method of making amphetamine free base.
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WO/2007/038277A3 |
The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: (I) from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
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WO/2007/036570A1 |
The present invention relates to a method for fractionating stereoisomeric compounds which have at least one alcohol group and/or amino group, by distillative separation in the presence of a chiral discriminator which takes the form of a...
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WO/2007/023129A3 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/023129A2 |
The invention relates to a method for the racemic separation of compound-forming substances. Primarily, at least one fraction, which is enriched with an enantiomer, is produced in said method. Subsequently, preferred crystallisation is c...
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WO/2007/023056A1 |
The present invention relates to a process for the organo- catalysed kinetic racemate resolution of compounds of the general formula (II). It is thus possible through the action of catalytic amounts of enantiomerically enriched compounds...
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WO/2007/017424A1 |
A method for the determination of the enantiomeric composition of a chiral compound comprising : a) derivatising said chiral compound with a enantiomerically and diastereomerically pure compound of general formula (I) and b) analysing th...
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WO/2007/007828A1 |
Disclosed is a novel compound useful as a production intermediate for benzylamine derivatives. Also disclosed is a method for producing such a compound. Specifically disclosed is a method for producing an ethylenediamine derivative repre...
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WO/2007/004077A3 |
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite solvent to obtain tamsulosin. Optically p...
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WO/2007/004077A2 |
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite solvent to obtain tamsulosin. Optically p...
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WO/2007/000918A1 |
Benzylamine derivatives having structures represented by the general formula (1): (1) a method for the optical resolution of benzylamine derivatives which comprises using optically active mandelic acid as the reagent for optical resoluti...
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WO/2006/136866A1 |
The present invention relates to a process for optically resolving eszopiclone, comprising chiral chromatography. Preferably the process comprises a multi-column continuous process or a simulated moving bed process. Preferably the statio...
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WO2006058681A3 |
The invention relates to a method for producing enantiomer-enriched lactones by carbonylating lactones into anhydrides in the presence of a catalyst system, containing: A) at least one carbonylation catalyst A comprised of neutral or ani...
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WO/2006/099926A1 |
A process for preparing enantiopure E-(2S)-alkyl-5-halopent-4-enoic acids and their esters of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-C4-alkyl and X is chlorine, bromine or iodine, in which the corresponding r...
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WO/2006/087556A1 |
A process for separating enantiomers or isomers present in a liquid phase through formation and then subsequent decomposition of a host-guest complex coupled to membrane nanofiltration, comprising the steps of: (a) providing a first solu...
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WO/2006/083030A1 |
This invention provides a production process of a fatty acid as a constituent component of capsinoid suitable for use on a commercial scale. The production process is advantageous in that the fatty acid can be produced in a highly effici...
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WO/2006/058681A2 |
The invention relates to a method for producing enantiomer-enriched lactones by carbonylating lactones into anhydrides in the presence of a catalyst system, containing: A) at least one carbonylation catalyst A comprised of neutral or ani...
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WO/2006/056098A1 |
The invention relates to the process for resolving DL-ephedrine, DL-pseudoephedrine or the derivatives thereof and to the corresponding resolving agents. The D-(+)- or L-(-)-tartaric acid derivatives of formula (I) are the resolving agen...
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WO/2006/050633A1 |
The invention relates to the process for resolving DL-ephedrine or the derivatives thereof and to the corresponding resolving agents. The L-(-)-dibenzoyl-tartaric acid or its derivatives of formula (I) are the resolving agents for DL-eph...
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WO/2006/050887A1 |
The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula (I) wherein R1, R2 and R3, independently of each other, signify hydrogen, halogen, nitro, cyan...
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WO/2006/043906A1 |
A method is provided for resolution of two stereoisomers, for example enantiomers, from a mixture of same, using a chiral resolving agent to preferentially crystallize one stereoisomer over the other in an organic solvent.
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WO/2006/030278A1 |
The present invention is directed to a process for the isolation of the enantiomeric forms of modafinil with high enantiomeric purity and high overall yields by means of a continuous chromatographic process.
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WO/2006/027798A3 |
The present invention provides optically pure (S)-(+)-N-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanami
ne, a compound of formula (1), and optically pure (S)-isomer of compound of formula (4), wherein R1 and R2 both are methyl or R1 i...
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WO/2006/013581A3 |
The present invention relates to novel chiral resolving agents and a process for resolution of racemic organic acids and their derivatives of the formula (+, -)-R1R2CHCOOR3 with Cis- (1S,4S)-4 [3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-me...
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WO/2006/013581A2 |
The present invention relates to novel chiral resolving agents and a process for resolution of racemic organic acids and their derivatives of the formula (+, -)-R1R2CHCOOR3 with Cis- (1S,4S)-4 [3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-me...
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WO/2006/011613A1 |
[PROBLEMS] To provide a method for producing a monatin having a configuration in 2-position of R configuration or a salt thereof through the isomerization of 2-position of a monatin having a configuration in 2-position of S configuration...
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WO/2006/007976A1 |
The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solv...
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WO/2006/004093A1 |
A process for industrially advantageously producing tamsulosin or a pharmacologically acceptable salt thereof, which are useful as a therapeutic agent for urination disorders accompanying prostatic hypertrophy. The process, which is for ...
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WO/2005/123659A1 |
The invention relates to a method of synthesising a compound having formula (I) and to the use thereof for the synthesis of ivabradine and the pharmaceutically-acceptable acid addition salts and hydrates of same.
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WO2005090334A3 |
The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspas...
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WO/2005/103005A1 |
A process by which the desired, optically active isomer of D,L-β-pyridylalanine is efficiently obtained. The process, which is for selectively producing an optically active isomer of β-pyridylalanine, comprises treating D,L-β-pyridyla...
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WO/2005/090334A2 |
The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspas...
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WO/2005/085184A1 |
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an &agr ,β-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable...
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WO/2005/082850A1 |
A process for efficiently producing a monatin useful as a sweetener, especially an optically active monatin, comprising carrying out a reaction of isomerization at 2-position of a monatin whose 2-position and 4-position configurations ar...
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WO/2005/080300A1 |
An optical resolver comprising a bicycle[3.3.0]-2-oxaoctane compound represented by the formula [1], [2], or [3]; a process for producing an optically active isomer which comprises reacting the optical resolver with a mixture of opticall...
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WO/2005/077891A1 |
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-
hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fl...
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WO/2005/070911A1 |
The invention relates to the resolution of racemic mixtures, and in particular to the separation of enantiomers of chiral alcohols utilising recyclable chiral auxiliaries. The present invention also relates to a process for preparing the...
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WO/2005/058776A1 |
The present invention relates to a process for the resolution of derivatives of &agr -amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with ...
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WO/2005/056609A1 |
A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide i...
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WO/2005/049571A1 |
A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(-) Amlodipine and R(+) Amlodipine without isolation of the chiral free base wherein the product has optical purity ranging between 96-99% is...
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WO/2005/049557A1 |
A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively...
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WO/2005/047235A1 |
The present invention relates to the isomerisation of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim 1.
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