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WO/2007/000918 |
Benzylamine derivatives having structures represented by the general formula (1): (1) a method for the optical resolution of benzylamine derivatives which comprises using optically active mandelic acid as the reagent for optical resoluti...
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WO/2006/136866 |
The present invention relates to a process for optically resolving eszopiclone, comprising chiral chromatography. Preferably the process comprises a multi-column continuous process or a simulated moving bed process. Preferably the statio...
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WO/2006/099926 |
A process for preparing enantiopure E-(2S)-alkyl-5-halopent-4-enoic acids and their esters of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-C4-alkyl and X is chlorine, bromine or iodine, in which the corresponding r...
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WO/2006/087556 |
A process for separating enantiomers or isomers present in a liquid phase through formation and then subsequent decomposition of a host-guest complex coupled to membrane nanofiltration, comprising the steps of: (a) providing a first solu...
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WO/2006/083030 |
This invention provides a production process of a fatty acid as a constituent component of capsinoid suitable for use on a commercial scale. The production process is advantageous in that the fatty acid can be produced in a highly effici...
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WO/2006/058681 |
The invention relates to a method for producing enantiomer-enriched lactones by carbonylating lactones into anhydrides in the presence of a catalyst system, containing: A) at least one carbonylation catalyst A comprised of neutral or ani...
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WO/2006/056098 |
The invention relates to the process for resolving DL-ephedrine, DL-pseudoephedrine or the derivatives thereof and to the corresponding resolving agents. The D-(+)- or L-(-)-tartaric acid derivatives of formula (I) are the resolving agen...
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WO/2006/050633 |
The invention relates to the process for resolving DL-ephedrine or the derivatives thereof and to the corresponding resolving agents. The L-(-)-dibenzoyl-tartaric acid or its derivatives of formula (I) are the resolving agents for DL-eph...
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WO/2006/050887 |
The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula (I) wherein R1, R2 and R3, independently of each other, signify hydrogen, halogen, nitro, cyan...
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WO/2006/043906 |
A method is provided for resolution of two stereoisomers, for example enantiomers, from a mixture of same, using a chiral resolving agent to preferentially crystallize one stereoisomer over the other in an organic solvent.
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WO/2006/030278 |
The present invention is directed to a process for the isolation of the enantiomeric forms of modafinil with high enantiomeric purity and high overall yields by means of a continuous chromatographic process.
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WO/2006/027798 |
The present invention provides optically pure (S)-(+)-N-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanami
ne, a compound of formula (1), and optically pure (S)-isomer of compound of formula (4), wherein R1 and R2 both are methyl or R1 i...
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WO/2006/013581 |
The present invention relates to novel chiral resolving agents and a process for resolution of racemic organic acids and their derivatives of the formula (+, -)-R1R2CHCOOR3 with Cis- (1S,4S)-4 [3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-me...
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WO/2006/013581 |
The present invention relates to novel chiral resolving agents and a process for resolution of racemic organic acids and their derivatives of the formula (+, -)-R1R2CHCOOR3 with Cis- (1S,4S)-4 [3,4-dichlorophenyl]-1,2,3,4-tetrahydro-N-me...
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WO/2006/011613 |
[PROBLEMS] To provide a method for producing a monatin having a configuration in 2-position of R configuration or a salt thereof through the isomerization of 2-position of a monatin having a configuration in 2-position of S configuration...
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WO/2006/007976 |
The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solv...
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WO/2006/004093 |
A process for industrially advantageously producing tamsulosin or a pharmacologically acceptable salt thereof, which are useful as a therapeutic agent for urination disorders accompanying prostatic hypertrophy. The process, which is for ...
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WO/2005/123659 |
The invention relates to a method of synthesising a compound having formula (I) and to the use thereof for the synthesis of ivabradine and the pharmaceutically-acceptable acid addition salts and hydrates of same.
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WO/2005/103005 |
A process by which the desired, optically active isomer of D,L-β-pyridylalanine is efficiently obtained. The process, which is for selectively producing an optically active isomer of β-pyridylalanine, comprises treating D,L-β-pyridyla...
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WO/2005/090334 |
The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspas...
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WO/2005/085184 |
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an &agr ,β-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable...
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WO/2005/082850 |
A process for efficiently producing a monatin useful as a sweetener, especially an optically active monatin, comprising carrying out a reaction of isomerization at 2-position of a monatin whose 2-position and 4-position configurations ar...
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WO/2005/080300 |
An optical resolver comprising a bicycle[3.3.0]-2-oxaoctane compound represented by the formula [1], [2], or [3]; a process for producing an optically active isomer which comprises reacting the optical resolver with a mixture of opticall...
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WO/2005/077891 |
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-
hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fl...
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WO/2005/070911 |
The invention relates to the resolution of racemic mixtures, and in particular to the separation of enantiomers of chiral alcohols utilising recyclable chiral auxiliaries. The present invention also relates to a process for preparing the...
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WO/2005/058776 |
The present invention relates to a process for the resolution of derivatives of &agr -amino acids. In particular the process is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallisation with ...
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WO/2005/056609 |
A cationic oligomer of a saccharide, wherein the saccharide is functionalized by a cationic group, for example an ammonium, phosphonium, imidazolium, or pyridinium group. In a preferred embodiment, the cationic oligomer of a saccharide i...
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WO/2005/049571 |
A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(-) Amlodipine and R(+) Amlodipine without isolation of the chiral free base wherein the product has optical purity ranging between 96-99% is...
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WO/2005/049557 |
A process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by comprising causing cells of a microorganism or a product of treatment of the cells, the microorganism having the ability to stereoselectively...
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WO/2005/047235 |
The present invention relates to the isomerisation of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim 1.
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WO/2005/040097 |
The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by resolving racemic β-amino alkylnitriles u...
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WO/2005/030730 |
An industrially advantageous production process which is an improved process for the production of an optically active &agr -amino-&epsiv -caprolactam (ACL). By the process, a desired optically active isomer having a high optical purity ...
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WO/2005/021502 |
A method for producing an optically active compound represented by the formula (I) below or a salt thereof is characterized in that a mixture of two kinds of optically active compounds represented by the formula (I) below or salts thereo...
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WO/2005/007612 |
A process for the production of optically active 1-(2-trifluoromethylphenyl)ethylamine or salts thereof which comprises reacting 1-(2-trifluoromethylphenyl)ethyl alcohol with a sulfonylating agent in the presence of a base to obtain a su...
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WO/2004/110586 |
The invention relates to chiral separation chromatographic and electrophoretic techniques. The aim of said invention is to obtain chiral stationary and mobile phases comprising an oligonucleotide which is specifically selected by a SELEX...
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WO/2004/096873 |
An optically active acetylene polymer represented by the following formula (I), produced by polymerizing an optically active 1-(dimethyl(10-pinanyl)silyl)-1-propyne and having a weight-average molecular weight of 10,000 to 1,000,000; a f...
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WO/2004/089871 |
A method for producing trans-2-[(&agr -methylbenzyl)amino] cyclopentanol being highly pure as a diastereoisomer, which comprises reacting a mixture of two diastereoisomers of trans-2-[(&agr -methylbenzyl)amino]cyclopentanol represented b...
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WO/2004/052883 |
In a process comprising synthesizing pyranes including [R-(R*,R*)]-N-[3-[1 [5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-p
yran-3- yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises t...
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WO/2004/046714 |
A method for preparing a separating agent for an optical isomer, which comprises a step of contacting a dope of an optically active polymeric compound with a porous carrier, to allow the porous carrier to carry the optically active polym...
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WO/2004/043908 |
A process for interconverting a mixture of cis-trans erythro-threo isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are usefull intermediates in the synthesis of cis isomers of benzamide...
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WO/2004/026247 |
Diketo- and pyridine-containing chiral crown ligands having at least two chiral bulky groups attached to two different chiral carbon atoms of the crown that are covalently bonded to or coated on suitable solid supports, and further coate...
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WO/2004/026469 |
A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Bronsted acid, with a salt...
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WO/2004/014821 |
The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram invol...
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WO/2004/014959 |
The invention relates to novel cyclodextrin derivatives which are characterised in that at least one of the hydrogen atoms borne by the carbon atoms in position 3 and/or 5 and/or 6 of the glucopyranoside units (or glucose) contained in t...
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WO/2004/013081 |
Process for the preparation of primary amines of formula (I): on enclosed where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): (formula see on enclosed paper version) where R1 and R...
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WO/2004/006829 |
The invention relates to a method of separating enantiomers R(-)- and S(+)-5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenz
enesulphonamide. The inventive method consists in: (a) reacting a mixture of the aforementioned enantiomer...
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WO/2004/005220 |
The invention concerns a method for resolving a racemic to obtain its optically active isomer characterized in that it consists in reacting, with diprogulic acid or one of its salt, a racemic of general formula (I), wherein: Ar is a hete...
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WO/2004/002924 |
A process and intermediates for producing 3-amino nitriles. The process involves resolving an enantiomeric mixture of chiral 3-amino nitriles in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. ...
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WO/2004/000761 |
A method of separating the enantiomers of a chiral compound from a mixture, the mixture including a first and second enantiomer, by introducing the mixture into a fluid flow leading to a separation means which changes the distribution of...
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WO/2003/087808 |
A packing that is suitable for fractionation by simulated moving bed chromatography, ensuring high productivity. In particular, an optical isomer separation packing for simulated moving bed chromatography wherein a polysaccharide derivat...
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