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WO/2008/038300A8 |
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2- phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1 '-binaphthalene (BINO...
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WO/2006/027798A3 |
The present invention provides optically pure (S)-(+)-N-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanami
ne, a compound of formula (1), and optically pure (S)-isomer of compound of formula (4), wherein R1 and R2 both are methyl or R1 i...
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WO/2007/038277A3 |
The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: (I) from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
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WO/2009/047408A1 |
The invention relates to a method for the continuous crystallisation of a mixture of stereo-isomers and a resolution agent in a solvent, said mixture and resolution agent being injected into a continuously stirred reactor and the crystal...
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WO/2009/025791A2 |
The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)d...
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WO/2009/025169A1 |
A method for purification of an optically active α-fluoro- carboxylic acid ester represented by the general formula [1] by removing fluoride ions from the ester to reduce the amount of fluoride ions contained in the ester: [Chemical for...
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WO/2009/016251A1 |
The present invention refers to a process for the resolution into one of its enantiomers of the racemate of compound of formula (I): which comprises separating said one of its enantiomers from a diastereoisomeric salt of formula (II), wh...
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WO/2009/008303A1 |
Disclosed is a process for producing optically active mirtazapine with a high degree of efficiency. Specifically disclosed is a process for producing optically active mirtazapine by optically resolving an R/S mixture of mirtazapine with ...
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WO/2008/155752A1 |
The present invention provides an improved method for obtaining cisatracurium besylate, which preferably includes chromatographically separating cisatracurium besylate from a mixture of (1R,1'R)-atracurium isomers via flash chromatography
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WO/2008/156095A1 |
Disclosed is a method for producing an optically active trans-2-aminocyclohexanol which is characterized in that a trans-2-aminocyclohexanol in a racemic form and an optically active 2-methoxyphenyl acetic acid are reacted and then an op...
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WO/2008/152497A1 |
The present invention relates to a method for differentiating and quantifying the enantiomers, thereby determining the enantiomeric purity, of darifenacin and its intermediate compounds and salts thereof. In addition, the invention relat...
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WO/2008/148912A1 |
The invention relates to a novel method and a device for producing crystals from a substance. According to said method: (i) a saturated dissolution of the substance to be crystallised is prepared in a suitable solvent in a reaction vesse...
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WO/2008/150000A1 |
Disclosed is a novel method for producing an optically active form of etodolac. Specifically disclosed is a method for producing an optically active form of etodolac at a high productivity rate, at a low cost and in a simple manner. The ...
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WO/2008/146826A1 |
A process for efficiently and economically producing an optically active styrene oxide compound having a target configuration. The process for producing an optically active styrene oxide compound comprises subjecting a racemate of a styr...
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WO/2008/143925A1 |
A process for separating the diastereomers of a compound such as dihydrodecafluoropentane by using an ionic liquid to increase separation efficiency. The process may involve separation of thethreo and erythro diastereomers of HFC-4310mee...
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WO/2008/144198A1 |
High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrop...
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WO/2008/140074A1 |
Disclosed is a method for producing an optically active carboxylic acid ester directly from a racemic secondary alcohol and a carboxylic acid. Also disclosed is a method for optically resolving a racemic secondary alcohol in the same met...
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WO/2008/136527A1 |
Disclosed is a method for purifying an optically active dioxopyrrolidine derivative represented by the general formula (I): (I) wherein R1 represents a lower alkyl which may have a substituent; X represents a hydrogen atom or R2NH- [wher...
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WO/2008/107887A3 |
The present invention provides an improved method of chromatographically separating the isomers of (lR,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably p...
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WO/2008/117271A1 |
Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes eluting from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the prese...
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WO/2008/111631A1 |
Disclosed is an important production intermediate for an optically active phthalazinone derivative [1], which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for producing...
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WO/2008/107887A2 |
The present invention provides an improved method of chromatographically separating the isomers of (lR,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably p...
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WO/2008/102920A1 |
Disclosed is an optical isomer separating filler having separation performance/separation characteristics different from those of conventional optical isomer separating fillers, which is capable of separating an optical isomer which cann...
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WO/2008/102720A1 |
The invention is directed to a method for producing optically active 3-aminopiperidine or a salt thereof, in which racemic nipecotamide is converted into optically active nipecotamide and optically active nipecotic acid by stereoselectiv...
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WO/2008/102671A1 |
Disclosed is a method for easily isolating/purifying and separating/removing (2S,3R,4S)-4-hydroxyisoleucine with high purity and high yield. Specifically disclosed is a method for purifying (2S,3R,4S)-4-hydroxyisoleucine or a chemically ...
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WO/2008/019055A3 |
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.
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WO/2008/099730A1 |
Disclosed is a novel optical resolving agent for an amine compound, which can be produced on an industrial scale in a simple manner and at low cost. An optically active 2-(aroyloxy)propionic acid can be used as an optical resolving agent...
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WO/2007/103221A3 |
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...
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WO/2008/072773A1 |
Disclosed is a production method comprising the steps (A)-(E) below, which enables to commercially and safely produce (1R,2R)-2-amino-1-cyclopentanol or a hydrochloride thereof.
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WO/2008/070909A1 |
The present invention relates to a process for obtaining the R-enantiomer of salbutamol from a mixture of the enantiomers of salbutamol by a crystallization of said R-enantiomer as its salt with R-ibuprofen from a solution or slurry of a...
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WO/2008/053652A1 |
A process for producing 1-hydroxy-4-aminoadamantane shown below. wherein R1 and R2 independently represent a hydrogen, a halogen, a carboxy, a nitro, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylsulfonyl...
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WO/2008/038300A1 |
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2- phenyl propionic acid, diethyl tartrate, 2,2'-dihydroxy-1,1 '-binaphthalene (BINO...
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WO/2008/029785A1 |
Disclosed is a polysaccharide derivative containing a structure wherein hydrogen atoms in a hydroxy group or amino group at the 2-position and the 3-position of a structural unit of polysaccharide are substituted with different substitue...
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WO/2008/019055A2 |
Optically pure 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is prepared. The 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline tartrate is particularly useful for preparing solifenacin succinate.
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WO/2008/015689A1 |
A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate...
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WO/2008/012047A1 |
The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
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WO2007092264B1 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO2007060412A8 |
Method and apparatus for temperature controlled processes in a vessel to provide improved process control, in particular to enable controlled temperatures to be applied to a substance in different process zones of a vessel, has a series ...
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WO/2007/088571A3 |
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiome...
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WO/2007/111706A3 |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof.
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WO/2007/092264A3 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO/2007/111706A2 |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof.
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WO/2007/105729A1 |
Disclosed are: a process for production of 3-amino-2-hydroxyhexanoic acid cyclopropylamide with high efficiency, which is suitable for the production in an industrial scale; an intermediate compound useful for the process; and a process ...
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WO/2007/103221A2 |
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...
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WO/2007/075609A3 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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WO/2007/097336A1 |
A process by which (2R,3R)- and (2S,3S)-3-phenylisoserine derivatives useful as an intermediate for medicines can be easily and industrially advantageously produced. A salt of (2R,3S)- or (2S,3R)-3-phenylglycidic acid is reacted with amm...
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WO/2007/093764A1 |
The present invention relates to a process for the cyanation of imines, particularly to the asymmetric cyanation of imines. The Strecker reaction consists of a reaction between an aldehyde and an amine to form an imine, followed by the c...
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WO/2007/092264A2 |
The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is ...
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WO/2007/088571A2 |
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiome...
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WO/2007/075609A2 |
A method is disclosed for producing a chiral gel. A polymer including chiral monomers, such as a protein, is dissolved to generate a sol, which is optionally dialyzed. The sol is contacted with a crystallization inhibitor that allows it ...
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