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JPS6328897B2 |
A novel process for the preparation of (R) or (S) 2-allyl-3-methyl-4-hydroxy-2-cyclopentene-1-one comprising reacting a boron halide with an ester of a chiral carboxylic acid of the formula where A is organic group of a chiral carboxylic...
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JPS63135351A |
NEW MATERIAL:The compound of formula I [X and Y are H or together form an oxo group; A1 is H, methylene or carbonyl; A2 is H, CN, carbamoyl, carboxy or alkoxycarbonyl; m and n are integer; R1 is -COOR2 (R2 is alkyl, phenyl, etc.), group ...
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JPS6323181B2 |
A process for asymmetric synthesis of optically active 2-alkanoyl-1,2,3,4-tetrahydro-2-naphthol compounds of the formula: from L-proline or its ester and the following carboxylic acid of the formula: or its reactive derivative through th...
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JPS6320214B2 |
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JPS6366135A |
Novel 1,3-Diaryl cyclopentanes were prepared. These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or diso...
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JPS6312051B2 |
Compounds of the formula wherein R1 is (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkyl substituted by halogen; C1-4 alkoxy; C6-10 aryl; C6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C1-4 alkyl groups or a chloromethyl, ...
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JPS6333341A |
PURPOSE: Glycosides in plants are extracted with a supercritical or subcritical fluid after or at the same time of hydrolysis into the saccharide moiety and the aglycon moiety whereby the aglycon moiety is separated with industrial advan...
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JPS6322044A |
NEW MATERIAL:1,2-Dihydronaphthalene derivatives expressed by formula I [R1 and R2 are H, alkyl, halo lower alkyl, -(CH2)mO2R3, -(CH2)mCONR3R4 (R3 and R4 are H or alkyl; m is 0 or 1), -(CH2)nNR3R4 (n is 1 or 2) or -(CH2)nOR3 (the wedge li...
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JPS631301B2 |
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JPS6259099B2 |
3 beta -Hydroxy-18 beta -olean-9-en-30-oic acids having anti-ulcer activity of the formula (I) compositions containing the same and process for their preparation.
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JPS62270547A |
PURPOSE: To obtain pisiferic acid or an analog thereof usable as a medicine, by treating a plant body or extract thereof containing the pisiferic acid or analog thereof with a fluid in a supercritical state. CONSTITUTION: A plant, e.g. C...
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JPS62270543A |
NEW MATERIAL:A compound expressed by formula I {n is 2 or 3; R1 has 0W3 unsaturated bonds and represents [lower alkoxy, lower alkoxycarbonyl, CH(OR11)2 (R11 is substituted by a lower alkyl, etc.)] 1W10C aliphatic group or H; Y is CO2H, C...
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JPS62226937A |
NEW MATERIAL:A compound of formula I (the bond containing dotted line is single or double bond; A and B are carbonyl-type O, OH, CH2OH, alkoxy, aldehyde, hydroxycarbonyl, alkoxycarbonyl, hydroxycarbonylmethyl or alkoxy carbonylmethyl; R1...
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JPS62205043A |
9,10-Dihydro-phenanthrene derivatives of the formula (I> wherein R1 represents a) carboxy; b) esterified carboxy; group, wherein each of Ra and Rb is hydrogen or C1-C6 alkyl, or Ra and Rb, taken together with the nitrogen atom to which t...
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JPS6240348B2 |
Novel lactones of 2,2-dimethyl-cyclopropane-1-carboxylic acids of the formula I wherein X1, X2 and X3 when identical are selected from the group consisting of chlorine and bromine and when at least two are different, are selected from th...
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JPS62145093A |
There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for t...
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JPS6228140B2 |
Aldol derivatives of the formula, …… wherein C = W is a carbonyl group or a protected carbonyl group are intermediates for producing methanoprostacyclin derivatives which are useful medicines for prevention of thrombosis. Such a comp...
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JPS6225355B2 |
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JPS6220176B2 |
Compounds of the formula VI in which the radicals have the meanings given in Claim 1 are prepared by eliminating the acid R<1>OH from a compound of the formula V in which R<1> denotes a radical derived from a strong acid R<1>OH. The comp...
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JPS6220177B2 |
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JPS6218537B2 |
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JPS6213938B2 |
Compounds of the formulaand the anhydrides or imides thereof, wherein Rf is a perfluoroalkyl group, Y is oxygen or > NR and R is hydrogen or alkyl.These compounds can be prepared by a free radical catalyzed addition of a perfluoroalkyl i...
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JPS6251604A |
PURPOSE: A dermal drug for external use, obtained by incorporating dextran sulfate or a salt thereof and glycyrrhetinic acid or a derivative thereof with other components and capable of preventing and improving the skin roughening and fu...
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JPS6219552A |
NEW MATERIAL:A compound expressed by formula I [X is O or S; R1WR3 are H, halogen, alkyl or part of formula II is formula III (R3' is H, halogen or alkyl; R4 is formula IVWVII (W is O or S; R6WR8 are H, halogen, nitro, alkyl, OH or alkox...
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JPS622573B2 |
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JPS61282338A |
NEW MATERIAL:A condensed ring compound expressed by formula I (R1 is H or lower alkyl). EXAMPLE: A compound expressed by formula II (R1 is CH3). USE: A synthetic intermediate for decaline derivatives expressed by formula III which are pl...
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JPS6158456B2 |
Compounds having the formulawherein A when taken individually is hydrogen; B when taken individually is hydroxy or alkanoyloxy having from one to five carbon atoms;A and B when taken together are oxo;R, is hydrogen, benzyl, or R1' wherei...
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JPS6157831B2 |
Novel tricyclic lactones, viz. 10,10-dimethyl-4-oxa-tricyclo[7.1.1.03,8]undec-3(8)-en-5-one
and 10,10-dimethyl-4-oxa-tricyclo[7.1.1.03,8]undecan-5-one, and use thereof as perfuming or flavor-modifying ingredients.
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JPS61268648A |
PURPOSE: To obtain oleanolic acid having anti-inflammatory action, antirheumatic action, spermaticidal action, antiulcer action and antidiabetic action, etc., economically in high efficiency, by using the cake left after the removal of c...
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JPS6154773B2 |
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JPS61263916A |
Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of the as prodrug functioning compounds and compounds obtained herein.The pharmaceutical compositions of the inven-' ti...
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JPS6150936B2 |
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JPS6150935B2 |
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JPS61238758A |
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula wherein R1 and R2 each are independently hydrogen or (lower)alkoxy, or R1 and R...
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JPS61205231A |
NEW MATERIAL:A compound expressed by formula I (R is H or lower alkyl). EXAMPLE: 1-(Methoxycarbonyl)bicycle[4.4.0]deca-4,6-diene-3,8-dione. USE: A medicine and agricultural chemical or an intermediate there having antimicrobial action an...
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JPS6136517B2 |
Novel lactones of 2,2-dimethyl-cyclopropane-1-carboxylic acids of the formula I wherein X1, X2 and X3 when identical are selected from the group consisting of chlorine and bromine and when at least two are different, are selected from th...
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JPS6133029B2 |
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JPS6130552B2 |
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JPS6129940B2 |
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JPS6129341B2 |
Optically active compounds of the formula: are prepared by reduction of optically active corresponding compounds of the formula: in which one R denotes an oxo or hydroxyl group, the other R denotes hydrogen or both Rs denote oxo groups o...
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JPS6125012B2 |
A novel process is described for the preparation of compounds of formula wherein R2 and R3 are each chloro or bromo; X is carboxyl, nitrile, optionally substituted carbonamide, carbonyl halide or an ester group. Those compounds wherein X...
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JPS6122956B2 |
PURPOSE:A microorganism belonging to Pseudomonus is cultured in a medium containing biphenyl and the culture is subjected to extraction to give 2-hydroxy-6- oxo-6-phenylhexanoic acid used for intermediate of bactericidal agent, drugs and...
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JPS6121216B2 |
Prostacyclin derivatives of formula (I): (I) (wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents an alkenyl group having from 8 to 12 carbon atoms; and n represents an integer of from 1 to 8, inclusive) and pharm...
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JPS61103850A |
NEW MATERIAL:A 3-(indan-5-yloxy(or thio)cyclopentanecarboxylic acid deriva tive shown by the formula I (X is O, or S; R is H, or 1W3C alkyl) or its nontoxic salt when R is H. EXAMPLE: 1,3-trans-3-[{(2RS)-2-cyclopentyl-2-methyl-6,7-dichlo...
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JPS6191155A |
NEW MATERIAL:The pisiferic acid derivative of formula (R1 is H or ≥2C alkyl; R2 is H or ≥2C alkyl; when R1 is H, R2 is ≥2C alkyl, and when R2 is H, R1 is ≥2C alkyl). EXAMPLE: O-Ethylpisiferic acid. USE: An antitumor agent having ...
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JPS6187642A |
The present invention relates to a novel, optimized process for the preparation of cyclohexanedionecarboxylic acid derivatives of formula I which can be carried out in a single vessel affording a very good yield, which process comprises ...
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JPS6185344A |
NEW MATERIAL:A compound shown by the formula I [R1 is OH, or group shown by the formula II (R6 is H, or alkanoyl; R7 is H, or alkayl), alkoxy, etc.; R2 is hydroxymethyl, alkanoyloxymethyl, etc.; R3 is H, OH, or oxo; R4 and R5 are formyl,...
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JPS6176432A |
NEW MATERIAL:The azulene derivative of formula I (R1 is H, 1W10C alkyl or alkenyl, hydroxycarbonyl or alkoxycarbonyl; R2 and R3 are H, or 1W10C alkyl or alkenyl). EXAMPLE: Methyl 3-acetyl-7-isopropylazulene-1-carboxylate. USE: Useful esp...
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JPS6151140A |
PURPOSE: To enhance raw storage stability before exposure and to form an image high in quality in a short time by incorporating a specified compd. as a basic precursor in a heat developable photosensitive material. CONSTITUTION: The heat...
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JPS6150916A |
PURPOSE: An antitumor agent containing diterpene as an active component. CONSTITUTION: An antitumor agent having excellent effect to inhibit the proliferation of Hela cell (a cell strain separated from human cervical carcinoma tissue) ca...
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