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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002513385A |
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
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JP3279415B2 |
PURPOSE: To obtain a resin composition excellent in an ability to absorb near-infrared rays by mixing a transparent resin with lead sulfide, a specified thiourea derivative and an amide derivative and to obtain a near-infrared-absorbing ...
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JP2002114751A |
To provide a fungicidal new derivative of phenyl(thio)urea or phenyl(thio)carbamate, to provide a method for producing the derivative, and to provide fungicidal compositions each containing such a derivative.This fungicidal new derivativ...
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JP2002510554A |
The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, th...
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JP2002510672A |
The invention is directed to an anion-complexing compound with the formula Iwherein R1 is a six-membered ring, Y' is -NHC(X)NH-, and Y'' is selected from the group consisting of -NHC(X')-, -C(X')NH-, and -NHC(X') NH-; and wherein X and X...
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JP2002510554A5 |
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JP3253299B2 |
where X1-X4 are each O or S; W is unsubstituted or substituted -CH=O, -CH=S, -CH=NH, -CH(X3R6)(X4R7), R6 and R7 are each C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C1-C6-alkoxy-C1-C6-alkyl or together form a carbon chain; R10 is H, OH,...
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JP3250825B2 |
PURPOSE: To provide the new substituted nitroguanidine derivative low in the toxicity to human bodies, fishes and natural enemies and having good safety and excellent control effects against insect pests. CONSTITUTION: A compound of form...
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JP2002501502A |
Compounds of formula (I), wherein R is an aromatic or a heteroaromatic ring; R<2> and R<3> are H, C1-C8alkyl, aryl, arylC1-C8alkyl, or heteroaryl; R<4> is an aromatic or a heteroaromatic ring or an amine; W, X, Y, are independently selec...
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JP2001527519A |
This invention relates to the use of compounds of formula (I) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) are defined herein.
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JP2001526255A |
The present invention provides compounds of formula (I). The present invention also provides methods of treating or preventing inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of formula (I).
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JP2001525388A |
The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1)...
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JP3238005B2 |
PURPOSE: To provide the silver halide photographic sensitive material, for a printing plate, superior in rapid processability and high in processing stability. CONSTITUTION: The photosensitive material contains at least one kins of compo...
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JP3232586B2 |
PURPOSE: To obtain a new organic compound having excellent insecticidal effects not only on insect pests of susceptibility group but insect pests of resistance group against organic phosphorous agent and carbamate agent. CONSTITUTION: A ...
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JP2001521532A |
A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia.
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JP2001519808A |
The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.
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JP3222050B2 |
To obtain a peptide strongly antagonizing against endogenous GnRH, inhibiting the internal secretion of LH and FSH and the release of steroids from the gonad of mammalian and having sufficient solubility at a pH of about 5-6.5. An artifi...
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JP2001513770A |
PCT No. PCT/SE98/00274 Sec. 371 Date Mar. 10, 1998 Sec. 102(e) Date Mar. 10, 1998 PCT Filed Feb. 17, 1998 PCT Pub. No. WO98/38180 PCT Pub. Date Sep. 3, 1998There are described processes for the preparation of a compound of formula I and ...
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JP3179599B2 |
PURPOSE: To obtain a new compound useful for preventing and/or treating thrombosis, arteriosclerosis, ischemic cardiopathy, gastric ulcer, hypertension, etc., due to its agonistic action on PGI2 receptors. CONSTITUTION: The objective com...
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JP3162532B2 |
PURPOSE: To provide a new compound exhibiting antithrombotic action by bonding to a PGI2 receptor and useful for the treatment of thrombosis, arteriosclerosis, ischemic cardiopathy, gastric ulcer, hypertension, etc. CONSTITUTION: The com...
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JP3161751B2 |
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JP2001114754A |
To provide a method for producing an S-alkylisothiourea safely, readily and in a high yield in comparison with a conventional method. This method for producing an S-alkylisothiourea of the general formula (R is a 1-5C alkyl group) compri...
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JP2001500470A |
Hydroximic acid derivatives, useful as pesticides, have the formula in which G is G3 or G4 having the formula: in which R5 is lower alkyl; R6 and R7 are, independently, hydrogen or lower alkyl; W is O, S, SO or SO2; X1, X2 and X3 are, in...
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JP3118738B2 |
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JP2000514049A |
PCT No. PCT/US97/10903 Sec. 371 Date Aug. 19, 1999 Sec. 102(e) Date Aug. 19, 1999 PCT Filed Jun. 24, 1997 PCT Pub. No. WO97/49680 PCT Pub. Date Dec. 31, 1997This invention relates to the use of phenyl ureas of formulas (I) and (II) in th...
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JP2000510833A |
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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JP2000510862A |
The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a ...
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JP3071448B2 |
Sulphonylureas of the formula where A is a bond or a C1-C10-hydrocarbon radical, R<1> is a saturated or unsaturated hydrocarbon radical which is optionally substituted by halogen, saturated or unsaturated alkoxy, alkylthio, alkylsulp...
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JP2000506538A |
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or...
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JP2000504722A |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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JP3032846B2 |
PURPOSE: To provide compounds useful as an intermediate for synthesis of an insecticide and a mitecide. CONSTITUTION: Compounds of formula I(R is hydrocarbon or acyl; X is electron- attracting group; Y1 and Y2 are ○ or S; A is divalent...
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JP3007138B2 |
Certain novel hydroxamic acid derivatives having the structureinhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, aller...
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JP3003941B2 |
Novel N-[substituted aryl]-N min -(substituted alkoxy)-urea and thiourea derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption o...
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JP2973497B2 |
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JP2958668B2 |
Composition containing… a) a lubricant or a hydraulic fluid and… b) at least one compound of the general formula I …… where x=1 or 2 and, if x=1, n=2 and R is as defined for R1 or, if x=2, n=1 and R is as defined for R4, and R1 i...
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JPH11510814A |
The present invention relates to a class of compounds represented by the Formula Ior a pharmaceutically acceptable salt thereof, whereinA ispharmaceutical compositions thereof and methods of using such compounds and compositions as alpha...
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JPH11240859A |
To obtain the subject new compound having excellent insecticidal activity. This compound is shown by formula I [R1 to R3 are each H, nitro, cyano, a halogen, a 1-3C alkyl, a 1-3C haloalkyl, a 1-3C alkoxy or the like; R4 is H, nitro, cyan...
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JPH11208123A |
To prevent the discoloration of ground color by adding a UV ray absorption agent in an undercoating layer and/or thermal recording layer, a UV ray interruption agent in the thermal recording layer and/or protection layer, a fluorescent d...
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JPH11209336A |
To obtain the subject new compound sowing more raised bioavailability than that of an already-known compound, useful for treating bodily disorders caused by deficiency of growth hormone. This compound is shown by formula I [R1 is H or a ...
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JPH11209339A |
To obtain the subject new monomer useful as a synthetic intermediate for providing an acetylene polymer having characteristics such as conductivity, thermochromism, etc., and excellent availability. This monomer is shown by the formula (...
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JPH11508569A |
PCT No. PCT/EP96/02695 Sec. 371 Date Dec. 23, 1997 Sec. 102(e) Date Dec. 23, 1997 PCT Filed Jun. 21, 1996 PCT Pub. No. WO97/02255 PCT Pub. Date Jan. 23, 1997Bis-oxime derivatives of the formula I W is oxygen or sulfur, and the other subs...
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JPH11193266A |
To obtain a silver halide photographic material excellent in image quality such as sharpness, graininess, resolving power or color reproducibility and providing a stable and ultrahigh contrast image even by treatment with a developer at ...
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JPH11193264A |
To obtain the subject new compound useful as a chemokine receptor antagonist capable of inhibiting diseases caused by the chemokine such as interleukin 8 or MIP-1 α. This compound is represented by the formula; R1-X1-ph-X2-A-Y- R2 [A is...
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JPH11507626A |
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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JP2895913B2 |
A butenoic acid compound is defined by the following formula:in which Z is O,S, vinylene or azomethyne, A is an alkylene and J is phenyl or etc. It is useful to treat the heart disease.
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JPH11139969A |
To obtain a pharmaceutical composition having excellent antioxidant actions and inhibiting actions on an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibiting actions and effective in suppression of arteriosclerosis, cardiac infarctio...
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JP2889377B2 |
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JP2887715B2 |
There is disclosed a color developer and a method for processing a silver halide color photographic material using said color developer. The color developer comprises at thiourea compound represented by the formula (I): wherein R1, R2, R...
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JPH11503110A |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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