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JPH059170A |
PURPOSE: To obtain a new compound useful as an excellent antitumor agent. CONSTITUTION: A compound shown by formula I [X1 and X2 are O, S(O)n ((n) is 0-2), N(R3) (R3 is lower hydrocarbon) or methylene; Y 18 NH-C (=Z)-NH (Z is O or S), N=...
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JPH051024A |
PURPOSE: To obtain a new benzenesulfonylisothiourea derivative and benzenesulfonylhydroxyguanidine derivative useful as intermediate for medicines or agricultural chemicals, especially an intermediate for germicide and herbicide. CONSTIT...
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JPH04364160A |
PURPOSE: To provide a novel thiourea derivative having a strong gastric acid secretion-inhibiting activity, a strong defense factor-increasing ability and further an antibacterial activity against Helicobacter pirorri, useful as an antib...
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JPH0478625B2 |
Novel compounds have a formula (I) wherein represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substitu...
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JPH04352753A |
PURPOSE: To obtain new indane derivs. and quinoline derivs. which have an effect to activate a potassium channel and are useful as a drug for cardiovascular diseases and as an antiischemic agent. CONSTITUTION: The compds. include a compd...
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JPH04346983A |
PURPOSE: To obtain the subject new compd. useful as a herbicide which shows good selective herbicidal effect and growth regulating property when it is used before and after germination of weed. CONSTITUTION: This compd. is expressed by f...
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JPH04338373A |
PURPOSE: To obtain a new disubstd. urea and thiourea each having cholesterol acyl transferase inhibiting activity as therapeutic agent for the prevention of coronary heart disease, etc. CONSTITUTION: The new disubstd. urea and thiourea a...
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JPH04506660A |
A CCK antagonist compound of formula (I) wherein G is (1) NH2 or (2) substituted amino; R9 is (1) hydrogen, (2) loweralkyl, (3) carboxy-substituted alkyl or (4) carboxyester-substituted alkyl; R10 is (1) hydrogen, (2) loweralkyl, (3) fun...
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JPH04312568A |
PURPOSE: To obtain the subject compound useful as a raw material for medicines, agricultural chemicals, additives, etc., for polymeric materials in high yield by reacting a 2,6-dialkylaniline with carbon disulfide in the presence of a te...
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JPH04273853A |
PURPOSE: To obtain guanylthiourea which is useful as an intermediate for triazine, an optical lightening agent, a plant protective, and as an ingredient of fertilizer, with excellent yield and in high quality. CONSTITUTION: When guanylth...
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JPH04264061A |
PURPOSE: To obtain a new diphenyl ether deriv. having superior insecticidal and miticidal actions and exterminating harmful organisms. CONSTITUTION: This diphenyl ether deriv. is a compd. represented by formula I (where X is F or Cl and ...
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JPH04230358A |
PURPOSE: To provide a new N-substitution derivative of α-mercapto alkylamine having enkephalinase suppressive power and neurotropic. CONSTITUTION: The compound and its acid addition salt of formula I (n=0), for example, ethanethioic aci...
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JPH04224554A |
PURPOSE: To provide a lipoxygenase-inhibiting compound derived from non- steroidal anti-inflammatory drug having a carboxylic acid functional group. CONSTITUTION: A compound of formula I [R1 is H, NR2R3, OR2, SR2 (R2 and R3 are H, an alk...
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JPH04210951A |
PURPOSE: To obtain a new 1-naphthylalkyl-3-phenylurea derivative useful as a therapeutic agent having blood cholesterol lowering action due to acyl-CoA- cholesterol acyltransferase (ACAT) inhibition for hyperlipemia or atherosclerosis. C...
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JPH04211050A |
PURPOSE: To provide a new fluorophenoxyphenylthiourea derivative exhibiting excellent miticidal activity to mites as well as excellent insecticidal activity against vermin having acquired resistance to organophosphorus pesticides and car...
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JPH04504261A |
Substituted phenyl, naphthyl, and thienyl N-hydroxy urea compounds form a class of potent inhibitors of 5- and 12-lipoxygenase and are thus useful compounds in the treatment of inflammatory disease states where leukotrienes and other pro...
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JPH0432051B2 |
This invention relates to novel guanidine derivatives of the general formula their isomers at the guanidine group and salts of such compounds. The compounds and their salts are useful as anthelmintics.
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JPH0425947B2 |
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JPH045660B2 |
Novel compounds have a formula (I)whereinrepresents a bicyclo (2,2,1) hept-2Z-ene, bicyclo (2,2,1) heptane, 7-oxabicyclo (2,2,1) hept-2Z-ene, 7-oxabicyclo (2,2,1) heptane, bicyclo (2,2,2) oct-2Z-ene or bicyclo (2,2,2) octane substituted ...
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JPH03294253A |
NEW MATERIAL:A compound shown by formula I [R1 is COOH, CONH2, CN, tetrazolyl or (substituted) aryl; R2 is (substituted) aryl or heterocyclic group; R3 and R4 are H, lower alkyl or (substituted) aryl; n is 0-2; X is O or S; Y is single b...
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JPH03287571A |
NEW MATERIAL:A sulfonyl compound expressed by formula I (R and R' are H,-COCHR,-COCR,-SO2CH3,-CO2C2H5,-CH2CH2R4-CH2CH2OH-CONHCH2CH
2R4, etc.; R4 is Cl, formula II, etc.; R1 and R2 are amine such as formula III or -NHCH2CH2Cl, hydroxyl su...
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JPH0375540B2 |
The subject of the invention is a process for the preparation of 2-(perfluoroalkyl)ethanethiols RfCH2CH2SH, Rf denoting a straight-chain or branched perfluoroalkyl radical containing from 2 to 20 carbon atoms. The proceses comprises reac...
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JPH03257013A |
PURPOSE: To produce both of thiourea which has high additional value and high purity rhodan salt by adding amine to an aq. soln. of thiourea and unreacted NH4SCN prepared by dissolving transition reaction product of NH4 SCN in water and ...
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JPH0367062B2 |
Activating thiourea dioxide is characterized by incorporating in the thiourea dioxide a substance which dissolves in water or an acidic aqueous solution and produces hydrogen.
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JPH03227964A |
NEW MATERIAL: A compound of formula I [formula II is formulae III-VII; R1 is (CH2)c-COQ, CH2-CH=CH-(CH2)d-COQ ((c) is 4-8; (d) is 1-5; COQ is carboxy, amide, ester, etc.), etc.; R2 is H or an optionally substd. 1-10C aliphatic hydrocarby...
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JPH03220168A |
NEW MATERIAL:A compound expressed by formula I [R1, R3 and R6 are H, 1-5C alkyl, 1-5C alkoxy, 1-5C alkylthio, halogen, nitro, CF3 or (substituted) amino; R2 is H or 1-5C alkyl; R4 and R5 are 1-15C alkyl, 1-5C alkoxy or halogen; X is O or...
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JPH0357892B2 |
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JPH0355467B2 |
The invention relates to N-phenoxyphenylisothioureas of the formula wherein each R1, R2 and R3 is hydrogen, halogen, C1-C4alkyl, C1-C4alkoxy, trifluoromethyl or nitro, each of R4 and R5 is C2-C4alkyl, R6 is C1-C6alkyl, C3-C6alkenyl or C3...
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JPH0347256B2 |
Novel alkane derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, or phenyl; R2 is hydrogen, C1-C6 alkyl, or C2-C6 alkenyl; R3 is hydrogen, C1-C10 alkyl, ph...
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JPH03148247A |
NEW MATERIAL: A compd. of formula I {where R = phenyl (CH2)n (where n=0-2), naphthyl; R1=H, alkyl; R2=H, hydrocarbon chain saturated or having 1-3 double bonds, p-phenylmethoxybenzyl, formula II, etc.; R3=H, a hydrocarbon chain saturated...
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JPH0331714B2 |
This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compound, a process for the preparation thereof an...
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JPH0395153A |
NEW MATERIAL:A compound of formula I (R1 is 5-18C alkyl; R2 and R3 are 1-5C alkyl, 1-5C alkoxy or halogen; R4 is H, 1-5C alkyl, 1-5C alkoxy or halogen; X is O or S). EXAMPLE: 1-(4-Octylphenyl)-3-(2,6-dichlorophenyl) urea. USE: A hyperlip...
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JPH03501731A |
Compounds of formula (I) and pharmaceutically acceptable salts thereof are described in which, n is 0 to 5; X<1> to X<5> are any accessible combination of hydrogen, halogen, C1-6alkyl, C1-6alkoxy, cyano, nitro, SONH2, SO2NH2, SO2CH3, SO2...
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JPH0323540B2 |
This invention relates to novel guanidine derivatives of the general formula their isomers at the guanidine group and salts of such compounds. The compounds and their salts are useful as anthelmintics.
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JPH0374359A |
NEW MATERIAL: A compound of formula I [X is O or S; R is H; R1 and R2 are each H, 1-6C alkyl, 3-6C alkenyl, etc., or R and R1 together form formula II ((n) is 0-8; R5 is H, alkyl, etc.), R and R2 together form formula III ((n) is 1-3); R...
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JPH0322380B2 |
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JPH0368551A |
PURPOSE: To obtain a compound useful as a standard sample required to determine amino acid sequence at a low cost in a short time by reacting a phenylthiocarbamyl derivative of an amino acid with a fluorescent amino compound. CONSTITUTIO...
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JPH0321015B2 |
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JPH0348648A |
NEW MATERIAL: A compound of formula I [wherein A and C are each a single bond or 1-8C hydrocarbon chain optionally interrupted by a heteroatom; B is formula II-VII (wherein X is O or S; R and R' are each H or 1-4C alkyl; and D is a chain...
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JPH0347155A |
PURPOSE: To provide a medicine for treating depression, cerebral insufficiency or dementias containing a specific amine such as N-butyl-4- chlorobenzenemethanamine novel excepting a part as an active component. CONSTITUTION: A compd. rep...
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JPH0341065A |
NEW MATERIAL:Compounds expressed by formula I (R1 and R2 are H, lower alkoxy, lower alkylthio, lower alkyl, lower alkoxycarbonyl, halogen, di-lower alkylamino, lower acylamino, OH, lower acyl or nitro; (n) is 2-6, except that R1 and R2 a...
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JPH038381B2 |
Rubber compositions comprising diene rubber and N-carbamoyl maleamic acid, N-thiocarbamoyl maleamic acid or derivatives thereof exhibit improved green strength or tack properties. Treatment of diene rubber above 130 DEG C. with the same ...
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JPH03500303A |
Polymeric polyamines containing internal urea, biuret, thiourea, dithiobiuret, and/or thioamide moieties, and polymers prepared therefrom. Isocyanate-functional prepolymers containing urea, biuret, amide, thiourea, dithiobiuret, and/or t...
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JPH032146B2 |
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JPH03382B2 |
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JPH0262547B2 |
The invention relates to a guanidine of the formula:- in which R<1> and R<2> are H, C1-10 alkyl, C3-8 cycloalkyl or cycloalkylalkyl in which the alkyl part is C1-6 and the cycloalkyl part is C3-8, each of the alkyl, cycloalkyl and cycloa...
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JPH02307335A |
PURPOSE: To permit the confirmation of connection of a battery by a method wherein the title circuit is provided with a detecting means, detecting that the secondary voltage of a transformer is lower than a predetermined voltage, and an ...
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JPH02291533A |
PURPOSE: To obtain a material used as a nonlinear element of a nonlinear optical device by utilizing a specific semi-organic salt crystal. CONSTITUTION: Each of the applications of advanced nonlinear optics, such as fast optical phase co...
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JPH02290841A |
PURPOSE: To provide a medicinal composition effective for the treatment of disturbances of the respiratory system, cerebrovascular disorders, neuron degenerative disorders, etc., containing a specified substituted thioura and a cyanoguan...
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JPH02504152A |
Compound of formula (I), wherein R1, W, R2, Z, A and B have the meaning given in claim 1, process for producing it, and its use as a renin inhibitor in the treatment of hypertension and chronic cardiac insufficiency and in the treatment ...
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