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JP2575183B2 |
Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and f...
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JP2569706B2 |
A benzoylurea derivative represented by the formula (I) described below is a useful insecticide which can be formulated into insecticidal and/or acaricidal compositions containing it as an active ingredient: wherein R1 is a chlorine or f...
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JPH093016A |
To obtain the subject new compound as a strong ligand for a melatonin receptor, having an effective action on sleep disorder, etc., anxiolytic, antipsychotic and analgesic characteristics, useful for treating Parkinson's disease, etc. Th...
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JPH093031A |
To obtain a new hydroxamic acid derivative in which a benzyl group containing an acetic acid derivative residue at the 2-position is bonded to an oxygen atom or a nitrogen atom which is not an oxime type, useful as an agricultural and ho...
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JPH08512318A |
Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of alpha 1 adrenergic agonists are physiologically active compounds i...
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JP2565602B2 |
Compounds of the formula I in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, d...
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JP2562475B2 |
The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds, having the general structure: wherein: the W-X moiety is selected from -C(O)NH-, -C(S)NH-, -S(O)2NH-...
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JPH08325217A |
To obtain the subject new compound represented by a specific formula, showing a very high affinity to melatonin receptor, and a good pharmacological and therapeutic advantaged both in vitro and in vivo, and useful for somnipathyl, etc. T...
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JPH08301826A |
PURPOSE: To produce a new compound, having high inhibiting activities against squalene epoxidase derived from mammals and useful for treating hypercholesterolemia, etc. CONSTITUTION: This compound is expressed by formula I [Q, V and W ar...
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JPH08301841A |
PURPOSE: To obtain a new squalene-epoxydase activity inhibitor having high safety and excellent anticholesterol action and useful for treating and preventing hypercholesterolemia, hyperlipemia and arterial sclerosis. CONSTITUTION: This s...
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JP2554322B2 |
2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloal...
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JP2553034B2 |
A functional polymer comprises a main chain of carbon-carbon bonds and at least 0.1% by weight of one or more pendant functional groups of the formula -CO-NH-CO-Rp wherein Rp is a photosensitive group.
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JP2547033B2 |
NEW MATERIAL:A compound expressed by formula I {X is formula II-formula IV [R5 and R6 are H, (substituted) alkyl, (substituted) aryl, etc.; R7 and R8 are H, (substituted) alkyl, (substituted) alkoxy, etc.; R10 is H or alkyl]; R1-R4 are H...
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JP2543690B2 |
The use is claimed of N-phenyl-N'-phenalkyl- (2-5C) alkylenediamines of formula R1-NR2-A-NR3-B-R4 (I, certain of which are new, or their pharmaceutically acceptable salts or solvates, for the prepn. of a medicament for the treatment or p...
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JP2541275B2 |
A benzoylurea derivative represented by the formula (I) described below is a useful insecticide which can be formulated into insecticidal and/or acaricidal compositions containing it as an active ingredient: wherein R1 is a chlorine or f...
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JP2538165B2 |
PURPOSE: To obtain a metallic chelating ligand capable of forming a metallic chelate complex useful as a diagnostic agent by substituting nitrogen atom in an aminocarboxylate with a substituted aromatic amide group. CONSTITUTION: This li...
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JPH08239353A |
To obtain a new compound having strong affinity with a melatonin effecting receptor and useful for treating seasonal melancholy, dysgryphia, etc., A compound of formula I (R1 is an alkyl or the like; A forms a cyclic ring such as naphtha...
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JP2522628B2 |
Peptides which include unnatural amino acids and which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. The peptides are analogs of the decapeptide GnRH wherein there is at ...
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JP2514863B2 |
The invention relates to N-phenoxyphenylisothioureas of the formula wherein each R1, R2 and R3 is hydrogen, halogen, C1-C4alkyl, C1-C4alkoxy, trifluoromethyl or nitro, each of R4 and R5 is C2-C4alkyl, R6 is C1-C6alkyl, C3-C6alkenyl or C3...
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JP2500316B2 |
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JPH08504481A |
PCT No. PCT/EP93/03383 Sec. 371 Date Jun. 15, 1995 Sec. 102(e) Date Jun. 15, 1995 PCT Filed Dec. 2, 1993 PCT Pub. No. WO94/13862 PCT Pub. Date Jun. 23, 1994Nickel-plated shaped parts are produced by galvanic precipitation of nickel from ...
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JPH08503932A |
The invention provides novel compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their preparation: (I) wherein R1 is -S(O)nCH2...
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JPH08503940A |
Isothiourea derivatives and their use in medicine, particularly in the treatment of conditions where there is an advantage in inhibiting nitric oxide synthase, pharmaceutical formulations comprising the same and processes for the prepara...
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JPH08109165A |
PURPOSE: To provide the subject new compound having nitrogen monoxide synthetase inhibiting action and useful for the treatment of cerebrovascular diseases, especially the symptom of the acute stage of occlusive cerebrovascular disease a...
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JPH08104670A |
PURPOSE: To obtain the subject new compound excellent in the inhibitory action on a nitrogen monoxide synthase found in intracerebral neurocytes and in the selectivity of the enzyme, and useful as a therapeutic agent for cerebrovascular ...
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JPH0825992B2 |
Isothiuronium salts of the general formula (I), (wherein, R<1> is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aralkyl or aryl, the said groups being optionally substituted by one or more hydroxy, mercapto and/or halogen; R<2...
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JPH08502240A |
PCT No. PCT/US93/03208 Sec. 371 Date Jun. 27, 1994 Sec. 102(e) Date Jun. 27, 1994 PCT Filed Apr. 8, 1993 PCT Pub. No. WO93/21151 PCT Pub. Date Oct. 28, 1993This invention relates to chelating agents useful for coupling metal ions to biol...
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JPH08502048A |
PCT No. PCT/US93/08708 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06280 PCT Pub. Date Mar. 31, 1994Compositions and methods for treating a patient infected with a metazoan parasit...
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JPH0816086B2 |
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JPH0841008A |
PURPOSE: To provide a carbon monoxide synthetase inhibitor useful for therapy and prevention of shock, hypotension, chronic articular rheumatism, ulcerative colitis, ischemic encephalopathy, tumor, insulin dependent diabetes mellitus, et...
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JPH08500582A |
PCT No. PCT/EP93/02158 Sec. 371 Date Feb. 13, 1995 Sec. 102(e) Date Feb. 13, 1995 PCT Filed Aug. 13, 1993 PCT Pub. No. WO94/04489 PCT Pub. Date Mar. 3, 1994.Cyclohexenone oxime ethers of the formula I
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JPH082865B2 |
For the preparation of compounds such as ranitidine, niperotidine and cimetidine a urea of the formula: R1-NH-C-NH-(CH2)n-SD-S-(CH2)n-NH-C-NH-R1 (I) which is synthesized by reaction with a compound of formula (VIII) [H2N-(CH2)n-S-](IX) i...
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JPH07330711A |
PURPOSE: To obtain the subject compound useful as a developer of a thermal recording material in high yield and purity by reacting thiodianiline with phenylisothiocyanate in a specific molar ratio in a mixed solvent containing an aprotic...
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JPH0798818B2 |
Novel five membered ring containing N-(bicyclic heterocyclyl)-4-piperidinamines of the formula the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-allergic ag...
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JPH0780831B2 |
Compounds of formula (I): for which the values of R, R1, R2 and X are defined in the description, which can be used as medicaments.
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JPH07206811A |
PURPOSE: To obtain a new thiourea derivative useful as a production intermediate for N-biphenylmethylthiazoline derivative which is useful as an agent for the treatment of circulatory diseases. CONSTITUTION: This thiourea derivative is a...
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JPH0768201B2 |
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JPH07188151A |
PURPOSE: To obtain the subject novel compound which comprises biaryl urea and related compounds, has a potassium channel activating activity and an anti-ischemic activity and is useful as an ischemia therapeutic agent effective for myoca...
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JPH07188150A |
PURPOSE: To obtain the subject novel compound derivative which is an aryl or heterocyclic cyanoguanidine derivative, has a potassium channel opening activity and is useful as a cardiovascular agent, especially as an antiischemic agent fo...
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JPH0764803B2 |
Capsaicin derivatives of general formula I wherein R is O, S or NH, R1 to R7 may be a variety of substituents, and X is acyclic hydrocarbon, are useful as pharmaceuticals, in particular as analgesics and anti-inflammatory agents. Precurs...
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JPH0759551B2 |
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JPH0753708B2 |
Compounds of formula II wherein one of R1 and R2 is branched lower alkyl and the other is hydrogen or branched lower alkyl, R3 is hydrogen or C1-4alkyl, R4 and R5 are hydrogen, halogen, C1-5alkyl, substituted C1-5alkyl, aryl, substituted...
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JPH0747571B2 |
Amphiphilic compound having one of the following structures: (X-T)n-A-Ym and (X-T)n-R-(T-A)n wherein X is a fluorocarbon terminal group, T is a polar linking group, A is a nucleus other than saturated lower aliphatic, Y is a polar nonlin...
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JPH0745457B2 |
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JPH0742267B2 |
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JPH07112964A |
PURPOSE: To obtain a new amidoxime derivative consisting of an aromatic amidoxime derivative, achieving high flowering ratio by applying it to a plant seed, having blooming acceleration action and useful as an excellent blooming accelera...
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JPH0737439B2 |
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JPH0737438B2 |
The invention relates to polyfluoroaklyl nitrogen compounds of general formula: RF-(CH2)2-X in which X denotes an isothiocyanate -N=C=S, carbodiimide -N=C=N(CH2)2-R'F or thiourea -NH-CS-A group, A denoting an optionally substituted amino...
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JPH07503737A |
PCT No. PCT/US93/03539 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Apr. 20, 1993 PCT Pub. No. WO93/24458 PCT Pub. Date Dec. 9, 1993A compound of the formula and the pharmaceutically acceptable salts thereof, wher...
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JPH0725728B2 |
Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N min -diarylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or athe...
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