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JPH0717501B2 |
An analgesic composition comprising capsaicin or a capsaicin analogue and an analgesic selected from the class of non-steroidal anti-inflammatory, antipyretic and analgesic drugs is disclosed. This combination has been found to exhibit u...
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JPH0733652A |
PURPOSE: To obtain subject pharmaceutical formulation for antitumor agents, etc., containing a specific benzoyl urea derivative and an ionic surface active compound, having good biological effectiveness, capable of providing stable suspe...
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JPH0689004B2 |
Compounds of formula (II) …… having antibacterial and beta-lactamase inhibitory properties and in which R<1> and R<2> represent hydrogen or an optionally substituted hydrocarbon or heterocyclic group, and R<3> represents hydrogen or ...
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JPH0688957B2 |
Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N min -arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or athero...
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JPH06293748A |
PURPOSE: To provide new compds. having action for activating potassium channels, useful for treatment of ischemia symptom and arrhythmia. CONSTITUTION: The derivs. are the compds. of formula I (where X is O, S, or -NCN; Y is O, S, single...
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JPH0678298B2 |
Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N min -arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or athero...
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JPH06239785A |
PURPOSE: To obtain the subject compd. having low toxicity, useful as a therapeutic drug for heart failure, hypertention, or the like by condensing a specified compd. with a nucleophilic reagent of a specified formula in the presence of a...
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JPH06234730A |
PURPOSE: To obtain a new benzoylguanidine and its pharmaceutically acceptable salt which are useful as medicaments for arrhythmia, myocardial infarction, angina pectoris and ischemic heart disease, and as antiatherosclerotics, agents aga...
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JPH0662531B2 |
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JPH0662567B2 |
Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: (A) wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds rep...
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JPH06506921A |
This invention relates to substituted alpha -aminoaldehydes, pharmaceutical compositions containing them and methods for using such compounds as antiviral agents.
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JPH06199817A |
PURPOSE: To obtain a new 3-aryl-trazine-2,4-dione which has a compatibility with important crop plants as well as a fairly excellent herbicidal activity against problematical weeds. CONSTITUTION: The compound is shown by formula I, e.g. ...
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JPH06199786A |
PURPOSE: To obtain a new compound which has a protein tyrosine kinase inhibiting action, useful as an antitumor agent and therapeutic agent of immunological diseases and inflammatory diseases associated with protein kinase, and which als...
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JPH06505963A |
Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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JPH0645574B2 |
The invention relates to novel compounds of formula I: wherein the symbols have the significances given in the description, the synthesis thereof and to the use of compounds of formula I for the control of pests such as insects mites and...
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JPH0645579B2 |
PURPOSE:To obtain a base precursor, consisting of a specific compound, capable of readily and rapidly releasing a base by heating, useful as a heat developing type recording material and having high hydrophobicity and preservation stabil...
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JPH06157454A |
PURPOSE: To obtain a compound useful as a raw material for thiourea and a synthetic intermediate for pharmaceuticals and agricultural chemicals in high efficiency by reacting a dithiocarbamic acid amine salt with a haloiminium salt as a ...
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JPH0637455B2 |
There are disclosed novel phenoxyphenylthioureas, -isothioureas and -carbodiimides of the formula I in which R1 represents C3-C7-cycloalkyl or C5-C8-cycloalkenyl, R2 represents C1-C6-alkyl, C5-C6-cycloalkyl or C5-C6-cycloalkenyl, R3 repr...
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JPH06128238A |
PURPOSE: To provide a new pyrimidinedione derivative having potassium channel opening activity and applicable for the treatment and prevention of disorders caused by the constriction of vascular smooth muscle and other smooth muscle. CON...
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JPH06107614A |
PURPOSE: To obtain a new compound useful as an antiulcer agent having suppressing action on aggressive factors and enhancing action on protective factors in combination, having high safety and capable of manifesting excellent effects. CO...
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JPH06503081A |
The present invention is concerned with compounds of formula (I), wherein m is 0 or 1; n is an integer of from 1 to 6 and p is an integer of from 0 to 3 with the proviso that n+p does not exceed 6; Ar is a mono-, bi-, or tricyclic aromat...
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JPH06503092A |
Compounds represented by formula (I) wherein B represents R<5> and radicals represented by formula (II) (values for the variables given herein), are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV prot...
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JPH0625176B2 |
The kit contains a number of short linkage elements which can be connected together, adjacent elements having a common rotation point and being mutually adjustable within a defined spatial angle. Adjacent elements can be fixed w.r.t. eac...
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JPH06502860A |
Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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JPH06502866A |
Hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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JPH06502859A |
Compounds represented by formula (I) wherein A represents R, R<13> and radicals represented by formula (II), B represents R<5> and radicals represented by formula (III) (values for the variables given herein) are effective as retroviral ...
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JPH0623161B2 |
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JPH06502414A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH0672985A |
PURPOSE: To obtain a new compound, having angiotensin II antagonistic action and useful for preventing and treating hypertension, congestive heart failure, etc. CONSTITUTION: The objective compound of formula I [A is single bond, 1-7C al...
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JPH0656764A |
PURPOSE: To provide a low toxic anti-arteriosclerotic agent excellent in safety, capable of reducing blood LDL-cholesterol level while raising blood HDL- cholesterol level, containing, as active ingredient, a specific dibutyl hydroxybenz...
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JPH0656765A |
PURPOSE: To provide a low toxic new compound excellent in safety, having such function as to reduce blood LDL-cholesterol level while raising blood HDL-cholesterol level, thus useful as e.g. an anti-arteriosclerotic, agent. CONSTITUTION:...
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JPH0614042B2 |
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JPH0585545B2 |
A process for preparing a compound of the formula wherein R is alkyl having one to six carbon atoms or benzyl, which comprises heating an S-alkyldithiobiuretium of the formula wherein R1 is alkyl having one to three carbon atoms with at ...
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JPH05310678A |
PURPOSE: To obtain a new compound having cholesterol lowering action in blood by ACAT inhabitation and useful for therapeutic agents for hyperlipemia, atherosclerosis, etc. CONSTITUTION: A compound of formula I [R1 and R6 are H, 1-5C alk...
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JPH05221959A |
PURPOSE: To treat atherosclerosis by using a N-phenylthiourea deriv. or its isolated form or salt. CONSTITUTION: A pharmaceutical compsn. containing a compd. expressed by formula I is effective for prophylaxis and treatment for atheroscl...
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JPH0557263B2 |
A S-(-N-alkoxycarbonyl, N-substituted)amino methyl isothiourea derivative of the formula: wherein, each of R<1>, R<2>, R<3>, R<4>, R<5> and R<6>, which may be the same or different, represents an alkyl group, an alkenyl group, an alkynyl...
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JPH05194359A |
PURPOSE: To provide new compounds useful as acetylcholine esterase-inhibitors for curing myasthenia, memory disorders and dementia. CONSTITUTION: The compounds of the formula I, e.g. 1-{2-[2-(N-benzyl-N- methylamino)ethoxy]ethyl}-3-(4-ni...
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JPH0549208B2 |
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JPH0545561B2 |
N-Sulfonyliminothiocarbonic acid diesters protect rice crops from phytotoxic damage caused by herbicides.
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JPH05503721A |
PCT No. PCT/US91/08026 Sec. 371 Date Jun. 8, 1992 Sec. 102(e) Date Jun. 8, 1992 PCT Filed Oct. 30, 1991 PCT Pub. No. WO92/07557 PCT Pub. Date May 14, 1992. ( alpha ) The present invention provides novel substituted anthraquinones having ...
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JPH05148218A |
PURPOSE: To obtain a new NhydroxyN-[3(2-substd. phenyl)prop-2enyl]urea and thiourea and their salts useful as an antiasthmatic or antiarthritic drug, a drug for adult dyspnea syndrome, and antiischemic drug. CONSTITUTION: This invention ...
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JPH0532389B2 |
A 2,4-dihalogenobenzoyl-(thio)urea of the formula (I) in which X represents sulphur or oxygen, X1 and X2 are identical or different and represent fluorine, chlorine, bromine or iodine, R1 represents hydrogen, halogen or optionally substi...
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JPH05112521A |
PURPOSE: To obtain a general production method capable of industrially producing from a new intermediate a nitroguanidine derivative especially having a safe and advantageous property as an agricultural insect pest control agent, useful ...
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JPH0528220B2 |
A compound having the formulawherein R1 represents halogen or methyl; R2 represents hydrogen or halogen; each of R3 and R4 represents halogen; and each of X and Y represents oxygen or sulfur.The compound is useful as insecticide.
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JPH05502033A |
The invention relates to bicyclo[3.3.0]octane compounds of formula I, (I) wherein the variable are defined in this specification, as well as their enantiomers, and their salts with physiologically compatible bases. alpha -, beta -, or ta...
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JPH0523260B2 |
A pharmaceutical composition effective in the protection of normal tissues against radiation induced damage comprising administration a compound of the formula R1-CO-NR3-/A/-S-R2 in which R1 is a radical corresponding to an amino acid R1...
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JPH0518623B2 |
PURPOSE:To enhance the compatibility with other ionic surfactant, by preparing a cationic surfactant having either one of a urea bonding group, a thiourea bonding group and a carbonamide group in the branched chain thereof. CONSTITUTION:...
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JPH0513952B2 |
PCT No. PCT/US86/02307 Sec. 371 Date Apr. 20, 1989 Sec. 102(e) Date Apr. 20, 1989 PCT Filed Oct. 29, 1986 PCT Pub. No. WO88/03140 PCT Pub. Date May 5, 1988.Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochl...
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JPH0510335B2 |
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JPH0532609A |
PURPOSE: To provide a new glycolic acid derivative and its salt usable as medicinally active substance for disease of cardia, circulatory organ and blood vessel, especially for prevention and treatment of hypertension, cardiac incompeten...
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