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JP3138540B2 |
PURPOSE: To provide novel substituted cyclopropylamino-1,3,5-triazine compounds and acid adduct salts thereof useful as coline inhibitor effective in the treatment of Alzhheimer's disease, senile dementia, depression, anxiety, inflammato...
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JP2001501628A |
The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R1a, R2, R2a, p, r and s are as defined in the detailed part of the present description or salts thereof, to metho...
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JP2001019690A |
To obtain an analog of BCH-189 from an inexpensive precursor.This method comprises such processes that an allyl ester 1 or ester is ozonized to produce an aldehyde 2, the aldehyde 2 produces a lactone 3 by reacting with thioglycolic acid...
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JP2001500517A |
Substituted carbamoyltriazoles of the formula I as defined in the specification and the agriculturally useful salts thereof, processes for their preparation and their use as herbicides.
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JP2001010957A |
To obtain the subject prophylactic or inhibitor having excellent preventive action and treating action on hepatopathy by making the prophylactic or the inhibitor include a specific compound containing two or three aromatic groups on a py...
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JP2000517303A |
Substituted 2-phenylpyridines of formula Iwhere R1 to R5 are described herein,their use as herbicides and for the desiccation and/or defoliation of plants.
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JP3117217B2 |
A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a beta -dioxolanyl purine nucleoside of the formula: wherein R is OH, Cl, NH2, or H, or a pharmaceutica...
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JP3110461B2 |
PCT No. PCT/CA94/00311 Sec. 371 Date Feb. 2, 1995 Sec. 102(e) Date Feb. 2, 1995 PCT Filed Jun. 7, 1994 PCT Pub. No. WO94/29301 PCT Pub. Date Dec. 22, 1994The present invention relates to a process for producing predominantly pure cis nuc...
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JP3105154B2 |
To obtain the subject new compound capable of readily synthesizing a low toxic effective anti-HIV compound. This 1,3-oxathiolane is represented by formula I [R1 is H; Z is S, S=O or SO2; R2 is represented by the formula (R3 is H or a 1-6...
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JP3098035B2 |
Novel heterocyclic ether compounds of formula (I), wherein A, B and R<2> are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful ...
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JP3095521B2 |
Piperazine derivs. of formula (I) and their acid addn. salts are new. A = 2-4C alkylene opt. substd. by 1 or more lower alkyl; Z = O or S; R = H or lower alkyl, R1 = mono- or bi-cyclic aryl or heteroaryl; R2 = mono- or bi-cyclic heteroar...
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JP3085675B2 |
There is provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.
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JP3083865B2 |
Cyclohexenone oxime ethers (I) where R1 is alkyl; A is substituted or unsubstituted alkylene or alkenylene, where methylene is replaced by an oxygen atom, a sulfur atom, a sulfoxyl group, a sulfonyl group or -NRa-, Z is phenyl or a 5- or...
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JP2000510439A |
Compounds of the formula (I) and salts thereof where R1 to R5, A, Z, X, X', n and m are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepared analogously to known processes using novel interme...
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JP2000509718A |
(57) [Summary] Compounds represented by formula (I), as well as their N-oxides and agriculturally suitable salts, are disclosed which are useful in controlling unwanted vegetation. In equation (I) above, Q is (Q-1), (Q-2) or (Q-3); and A...
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JP3062475B2 |
(-)-Cis-4-amino-1- (2-hydroxymethyl-1,3 -oxathiolan-5-yl)-(1H)- pyrimidin-2-one (I) and its derivs. are new. (I) contg. max. 5 wt% of (+)-enantiomer (pref. below 1 wt%) is also claimed. (I) is prepd. by sepn. from a racemic mixt., prefer...
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JP3047045B2 |
PCT No. PCT/KR95/00135 Sec. 371 Date Jun. 11, 1997 Sec. 102(e) Date Jun. 11, 1997 PCT Filed Oct. 21, 1995 PCT Pub. No. WO96/12716 PCT Pub. Date May 2, 1996Nucleoside derivatives represented by formula (I); wherein, R1 represents hydrogen...
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JP2000143662A |
To provide a new substituted 1,3-oxathiolane compound capable of being easily synthesized, having low toxicity, and useful as an effective anti- human immunodeficiency virus(anti-HIV) compound. A single enantiomer or the enantiomer mixtu...
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JP2000506124A |
PCT No. PCT/EP97/00803 Sec. 371 Date Aug. 24, 1998 Sec. 102(e) Date Aug. 24, 1998 PCT Filed Feb. 20, 1997 PCT Pub. No. WO97/30993 PCT Pub. Date Aug. 28, 1997Pyrazolylhetaroyl derivatives of the formula I where the substituents have the f...
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JP2000128787A |
To obtain a medicine composition having high antiviral activity and low cytotoxicity, useful for treating human immunodeficiency virus infection of patient by making the composition include an effective amount of a specific anti-human im...
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JP2000505449A |
PCT No. PCT/EP97/00802 Sec. 371 Date Aug. 17, 1998 Sec. 102(e) Date Aug. 17, 1998 PCT Filed Feb. 20, 1997 PCT Pub. No. WO97/30986 PCT Pub. Date Aug. 28, 1997Hetaroyl derivatives of the formula I where the substituents have the following ...
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JP2000053676A |
To obtain a new compound of a sulfur atom-containing aromatic hydrocarbon compound, and useful as a constituent material of an organic electroluminescence element having high thermal stability, high luminescent characteristics and a low ...
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JP2000500755A |
The present invention relates to novel biphenyl ether-oxazolines of the formula (I)in whichX, Y, Z, R1, R2, A, m and n have the meaning given in the description,to processes for their preparation and to their use for controlling animal p...
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JPH11322608A |
To obtain a pharmaceutical composition useful for treatment of viral infection, especially treatment of hepatitis B by using an oxathiolane nucleoside analog. This pharmaceutical composition for treatment of infection of hepatitis B comp...
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JPH11512083A |
The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis C.
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JPH11512105A |
Pyrazol-4-ylbenzoyl derivativeswhere the substituents L, M, X, Y and n have the meanings given in claim 1 andQ is a pyrazole ring, linked in the 4-position, of the formula IIwhereR15 is C1-C4-alkyl,R16 is hydrogen, C1-C4-alkyl or C1-C4-h...
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JP2960778B2 |
The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to (-)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)
-(1H)-pyri midin-...
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JP2960164B2 |
This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes of formula (1) wherein X is S, S=O, or SO2; Y is O, S, S=O, or SO2; R1 is hydrogen, trisubstituted silyl, substituted or unsubstituted C1-6 alky...
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JP2954357B2 |
The present invention relates to therapeutic combinations of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2
-cyclopentene-1-methanol (1592U89), 3'-azido-3'-deoxythymidine (zidovudine) and (2R,cis)-4-amino-]-1-(2-hydroxymeth...
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JPH11228567A |
To provide new compound that has high controlling effect against plant diseases as rice blast, rust and the like with increased labor saving and safety to environments and is useful as a plant diseases-controlling agent. This compound is...
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JPH11209377A |
To obtain the subject novel compound that is useful as a medicine, particularly a therapeutic agent having the action to inhibit the production of inflammatory cytokines as tumor necrotic factor(TNF) and the like. This compound is repres...
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JP2927546B2 |
(-)-Cis-4-amino-1- (2-hydroxymethyl-1,3 -oxathiolan-5-yl)-(1H)- pyrimidin-2-one (I) and its derivs. are new. (I) contg. max. 5 wt% of (+)-enantiomer (pref. below 1 wt%) is also claimed. (I) is prepd. by sepn. from a racemic mixt., prefer...
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JP2901160B2 |
Enantiomerically enriched cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolane-5-yl
)-(1H)-pyrimidin-2-one, derivatives and pharmaceutical compositions thereof.
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JP2902345B2 |
PURPOSE: To obtain a triazole antifungal agent excellent in antifungal activity, useful for human and animal nosomycosis. CONSTITUTION: A compound of formula I [Ar<1> is phenyl, a 5-membered to 6-membered aromatic heterocyclic group (the...
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JP2895961B2 |
The compounds of the formulawherein R1, R2, R3, R4, R5 and R6 are as defined herein, are useful in the treatment of stress-related and other diseases. These compounds have corticotropin-releasing factor antagonist activity and as such ar...
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JPH11140083A |
To obtain the subject new compound capable of manifesting excellent herbicidal effects and selectivity among crops and weeds and useful as a herbi cide. This new compound is a benzofuran derivative represented by formula I [A is a group ...
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JPH11140054A |
To obtain a new compound capable of withering only weeds without giving damage of crops and useful as a herbicide capable of providing perfect effect at a low dosage. This compound is represented by formula I[R1 is H, a (halo) alkyl, ace...
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JP2895121B2 |
The invention relates to novel compounds of the formula: wherein R<1>, R<2>, X and "Ar" are as defined in Claim 1; as well as pharmaceutically acceptable acid addition salts and stereo isomeres thereof. The compounds are described as hav...
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JPH11505522A |
PCT No. PCT/EP96/01547 Sec. 371 Date Oct. 21, 1997 Sec. 102(e) Date Oct. 21, 1997 PCT Filed Apr. 11, 1996 PCT Pub. No. WO96/33170 PCT Pub. Date Oct. 24, 1996The present invention relates to the compounds of formula (I) wherein R is carbo...
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JPH11116561A |
To obtain an epoxy compound at a low cost without using chlorine gas by reacting a specific carbonate with an alkylene oxide. A compound of formula I or II (Ra is a group of formula III or the like) (e.g. a bis-cyclic carbonate ester obt...
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JPH1180135A |
To obtain a new triazol compound or a pharmacologically acceptable salt thereof, showing an excellent antifungal activities against various fungi, and useful as a medicine, especially an active ingredient for an antifungal agent because ...
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JP2868671B2 |
PURPOSE: To provide a prescribed agent which consists of a combination of a specific 1,3-oxathiolanenucleoside analogue and another HIV replication inhibitor and has a synergistic viral effect and reduced cytotoxicity. CONSTITUTION: This...
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JP2852659B2 |
A piperazine derivative represented by the following formula or a salt thereof: which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.
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JPH1129567A |
To provide the subject new compound exhibiting remarkable controlling action on various plant blights such as rice blast, apple scab and late blight of tomato and usable as an active component of a new fungicide for agricultural and hort...
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JPH1129478A |
To obtain a pharmaceutical composition capable of treating and preventing diabetes as a hypoglycemic agent by including a dihydroquinoline derivative as an active ingredient. This composition contains a dihydroquinoline derivative of the...
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JP2851480B2 |
(-)cis-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-
pyrimidine -2-one in crystalline form, in particular as needle-shaped or bypyramidyl crystals, pharmaceutical formulations thereof, methods for their preparation and their use ...
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JPH10513186A |
The combination of the HIV protease inhibitor Compound J, 3TC, and, optionally AZT, ddI, or ddC, is useful in the inhibition of HIV protease, the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV an...
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JPH10512250A |
PCT No. PCT/EP96/00008 Sec. 371 Date Jul. 3, 1997 Sec. 102(e) Date Jul. 3, 1997 PCT Filed Jan. 4, 1996 PCT Pub. No. WO96/21646 PCT Pub. Date Jul. 18, 1996Substituted 2-phenylpyridines I I where substituents have the meaning described in ...
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JPH10511935A |
Compounds of formula (I), wherein R1 is mono- or di-substituted phenyl, n is zero or 1, X1 is oxygen, sulfur or =NCN, X2 and X3 are oxygen or sulfur, R2 is hydrogen or methyl, R3 is phenyl, halo-substituted phenyl, 2-naphthyl, IH-indol-3...
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JPH10279567A |
To obtain a new compound, which is an excellent antifungal agent especially effective against mycoses in humans and animals. This compound is represented by formula I [Ar1 is a (substituted) phenyl; Ar2 is a (substituted) naphthyl, a (su...
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