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JP2501650B2 |
PCT No. PCT/SE89/00528 Sec. 371 Date May 21, 1991 Sec. 102(e) Date May 21, 1991 PCT Filed Sep. 28, 1989 PCT Pub. No. WO90/03184 PCT Pub. Date Apr. 5, 1990The invention claims an iscom matrix which is not a lipid vesicle comprising at lea...
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JPH08119866A |
PURPOSE: To obtain an antitumor agent by using a 3-keto compound of triterpenes as an active ingredient. CONSTITUTION: This antitumor agent comprises containing a 3-keto compound of oleanane-type triterpenes expressed by formula I (R is ...
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JPH08503931A |
PCT No. PCT/FR93/00899 Sec. 371 Date May 5, 1995 Sec. 102(e) Date May 5, 1995 PCT Filed Sep. 17, 1993 PCT Pub. No. WO94/06402 PCT Pub. Date Mar. 31, 1994The invention relates to a cosmetic or dermatological composition. This composition ...
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JPH0899991A |
To obtain modified bile acids having linker structure useful for hypoliplemics or the like by reacting bile acid ketone with acetylenic compounds, transforming into acetylide by a strong base, followed catalytic hydrogenation by Pd/C. Th...
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JPH08503471A |
Invented are 17 alpha and 17 beta -substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5- alpha...
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JPH0826063B2 |
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JPH0822871B2 |
11 beta -(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I (I) wherein X is an oxygen atom or a hydroxyimino grouping N OH, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms,...
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JPH08501298A |
A human cataractous lens nuclei methanolic extract consists essentially of substances having a molecular weight lower than 3,000 daltons. The substances inhibit ATP hydrolysis by Na+, K+-ATPase and have affinity to the ouabain binding si...
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JPH0834794A |
PURPOSE: To obtain a new sterol compound having excellent antineoplastic activity, useful as a medicine, etc., by chemical modification of aragusterols extracted and isolated from a sponge belonging to Xestospongia. CONSTITUTION: This ne...
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JPH07116216B2 |
PURPOSE:To obtain the titled compound having immune adjusting actions, growing action on nerve projection of cell and differentiation introducing ability, by reacting a specific sialic acid derivative with cholesterol and hydrolyzing the...
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JPH07110871B2 |
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JPH07252294A |
PURPOSE: To obtain a new compound excellent in water solubility, having antiallergic activity, anti-inflammatory activity and antioxidizing activity, etc., thus useful for preventing or treating allergic diseases, inflammatory diseases, ...
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JPH07508034A |
PCT No. PCT/US93/04633 Sec. 371 Date Mar. 20, 1995 Sec. 102(e) Date Mar. 20, 1995 PCT Filed May 17, 1993 PCT Pub. No. WO93/23038 PCT Pub. Date Nov. 25, 1993Novel amino substituted 4-azasteroid 5 alpha -reductase inhibitors of formula (I)...
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JPH07224087A |
PURPOSE: To obtain a new steroid derivative efficiently and stereoselectively synthesizable by synthetic organic chemical technique without the need for using natural substance-derived materials with problems such as concerning resource ...
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JPH0772193B2 |
A novel steroid of the formula I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carb...
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JPH07196684A |
PURPOSE: To provide new steroid compounds of substituted 2β-morpholino- androstane derivatives having very potent anaesthetic activity and fast onset times and ideal sleep duration vs. recovery to full coordination profiles which are us...
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JPH07506363A |
PCT No. PCT/US93/03778 Sec. 371 Date Oct. 28, 1994 Sec. 102(e) Date Oct. 28, 1994 PCT Filed Apr. 22, 1993 PCT Pub. No. WO93/22333 PCT Pub. Date Nov. 11, 1993Invented are 17 alpha and 17 beta -substituted acyl-3-carboxy aromatic A ring an...
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JPH07173188A |
PURPOSE: To provide a new alisol having a specific molecular structure, activating the activity of choline acetyltransferase, and useful for cerebral function-improving agents used for the therapy of Alzhemmer's disease, etc., severe amy...
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JPH0737464B2 |
Novel compounds for use in electrochemiluminescent assays and characterised by containing the structure X - Y - ZwhereinX represents one or more nucleotides which may be the same or different, one or more amino aci...
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JPH07109286A |
PURPOSE: To obtain a novel derivative which is useful as an antiinflammatory agent of low toxicity because it has the inhibitory action against type III allergy. CONSTITUTION: A derivative of the formula I (R is monosaccharide, OHprotect...
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JPH07503708A |
Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sul...
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JPH0733335B2 |
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JPH0730109B2 |
DELTA <4>-3-keto, DELTA <1,4>-3-keto and 3 beta -hydroxy-17-keto-steroids are transformed into the corresponding 16 beta -methyl-17-keto-steroids by activating the C-16 position, metylating, and reacting with a strong base. The C-3 posit...
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JPH0789863A |
PURPOSE: To provide a method for isolating and purifying ginsenoside-Re, capable of facilitating isolation and purification of ginsenoside-Re from medicinal plants and providing an antiarrhythmic agent consisting essentially of the above...
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JPH0725789B2 |
The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.
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JPH0741496A |
PURPOSE: To provide a steroid derivative for preventing and treating diseases such as prostatic hypertrophy, prostatic cancer, etc., caused by excessive 5α- dihydrotestosterone, having excellent inhibitory action on testosterone 5α-red...
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JPH0733792A |
PURPOSE: To obtain a new glycosyl donor simply, in high yield and high selectivity by reacting an acyltetraalkylglycopyranoside with a trimethylsilyl ether of an alcohol in the presence of a catalytic amount of an acidic catalyst. CONSTI...
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JPH06511250A |
Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceut...
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JPH0699460B2 |
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JPH0689022B2 |
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1 alpha ,25-dihydroxyvitamin D3, the recognized circulating horm...
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JPH0676434B2 |
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JPH0667846B2 |
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JPH06234788A |
PURPOSE: To obtain a new compound useful for treating and preventing human or animal viral infections, especially infection with human immunodeficiency virus, cat immunodeficiency virus or the like. CONSTITUTION: The objective compound i...
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JPH0660195B2 |
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via ...
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JPH06219951A |
PURPOSE: To provide a drug for cardiovascular diseases such as cardiac insufficiency and hypertension which contains 17-(3-furyl)-and 17β-(4-pyridazinyl)-5β,14β- androstane derivs. which effect the cardiovascular system. CONSTITUTION:...
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JPH06211893A |
PURPOSE: To provide the novel derivative exhibiting low toxicity and useful for remedy for diseases such as hear failure, hypertension or the like containing the derivative active on cardiovascular system. CONSTITUTION: By condensing a 1...
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JPH0653756B2 |
17-Substituted-21-hydroxy or 21-acylated steroids are prepared from 20-enol steroids in two steps, the first comprising reaction with peroxymonosulfate ion in a biphasic phase-transfer-catalysed medium (which can give novel 20,21-epoxy-c...
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JPH0653754B2 |
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JPH06192287A |
PURPOSE: To obtain new safe compounds having low toxicities and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: There compounds of formula I [a wave line means that 17- positioned s...
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JPH06192286A |
PURPOSE: To obtain a new compound having an activity against the cardiovascular system and extremely low in toxicity and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: This compoun...
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JPH06504364A |
Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy,...
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JPH0635475B2 |
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1 alpha ,25-dihydroxyvitamin D3, the recognized circulating horm...
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JPH0635467B2 |
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JPH0633287B2 |
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JPH0632632B2 |
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JPH0665284A |
PURPOSE: To obtain the subject low-toxic new compd. useful as a therapeutic drug for cardiovascular diseases such as heart failure and hypertension. CONSTITUTION: This invention provides a compd. expressed by formula I or its salts, and ...
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JPH0656670A |
PURPOSE: To obtain a new derivative useful for treatment of hyperlipemia, having ability to regulate directly or indirectly, synthesis of LDL receptor at chromosome level. CONSTITUTION: The compound of formula I R<1> is 1-4C alkyl or 1-4...
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JPH0656868A |
PURPOSE: To provide a process for the easy synthesis of a 2-deoxy-2amino sugar derivative in a high yield. CONSTITUTION: 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxy carbonylamino)-β-D-glucopyranoside or 1,3,4,6-tetra-O-acety...
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JPH06501499A |
Steroidal and non-steroidal glycosides and a method of producing them are provided, wherein aglycon compounds are glycosylated with tri-O-acyl glucal using molecular or ionized halogen as reaction catalyst. The aglycon, which may be a no...
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JPH0640920A |
PURPOSE: To provide a treating agent for viral infections containing CHIKUSETSU saponin III as an active ingredient. CONSTITUTION: The agent contains a kind of saponin in CHIKUSETSU GIN SENG (a plant in Araliaceae) which has been known t...
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