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JP2002527448A |
This invention provides 5 alpha -pregnane-3 beta , (20S), 21-triol, 20-O- beta -glucuronide and 5 alpha -pregnane-3 beta ,20R-diol, 20-O- beta -glucuronide and pharmaceutically acceptalbe salts thereof which are useful as progestational ...
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JP3310301B2 |
A compound having the structure: wherein n is an integer from 1-5; each of R1 and R2 independently is optionally substituted C1-C6 alkyl; each of W and X is independently hydrogen or C1-C6 alkyl; Y is O, S or NR3 where R3 is hydrogen, C1...
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JP2002523422A |
The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids in...
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JP2002205997A |
To obtain a specific anorectic agent, to provide a method for producing the anorectic agent by synthesis, to obtain an anorectic composition containing the above agent, and to provide an anorectic method.The anorectic agent is a compound...
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JP3302346B2 |
To obtain an antidiabetic food or antiobestic food each having high activity, and excellent in hyperglycemia inhibitory action after eating. This antidiabetic food or antiobestic food is such one as to contain a carbohydrate digestive en...
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JP2002167330A |
To provide a skin whitening external preparation with excellent skin whitening effect and a melanogenesis inhibitor with excellent melanogenegsis inhibition.This skin whitening external preparation contains more than one or two withanoli...
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JP3273010B2 |
To obtain a compound useful for treating a disease corresponding to a sex steroid. This sex steroid inhibitor has a molecular structure of formula I (a dotted line is a double bond; R5 and R6 are each H, hydroxyl, etc.; R100 is a divalen...
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JP2002060384A |
To obtain a compound useful for treating breast cancer or other diseases promoted by their exacerbation due to the activation of sex steroid receptor, and to provide a medicament composition containing the above compound.This compound ha...
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JP3253181B2 |
PURPOSE: To obtain a photochemical labeling reagent useful for genetic phatogonomy by adding a digoxigenin derivative, a spacer molecule, and a furocoumarin derivative to the reagent. CONSTITUTION: A labeling reagent expressed by a formu...
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JP2001525806A |
This invention provides 3 beta -hydroxy-5,7,9-estratriene-17-one and a pharmaceutically acceptable salt of its 3-sulfate ester, which is useful as an estrogen.
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JP2001518896A |
This invention provides estra-5(10),7-dien-3 beta -ol-17-one or a pharmaceutically acceptable salt of its 3-sulfate ester, estra-5(10),7-dien-3 beta -ol-17-one 3-glucuronide or a pharmaceutically acceptable salt thereof, estra-5(10),7-di...
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JP3202240B2 |
The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed.
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JP3181589B2 |
PCT No. PCT/EP91/02493 Sec. 371 Date Oct. 27, 1993 Sec. 102(e) Date Oct. 27, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11277 PCT Pub. Date Jul. 9, 1992Compounds of the general formula I (I) are described, in which x represents an ox...
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JP3180855B2 |
PURPOSE: To provide a cockroach-collecting pheromone comprising a cockroach- attracting substance and a cockroach-restraining substance and useful as a cockroach-controlling agent extremely excellent in its controlling effect because of ...
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JP2001139483A |
To provide an effective preparation for the administration of a ginseng, its essence, ginseng component, their metabolites or their salts useful as a brain cell-protecting agent or nerve cell injury-treating agent, and especially useful ...
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JP3168542B2 |
The invention is directed to the control of cellular autophagy, cellular agglutination and the immobilization of motile cells. Such control is useful in, for example, the treatment of cancer, contraception, termination of pregnancy, remo...
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JP2001072697A |
To obtain a new compound having a lipid metabolism-accelerating activity and peroxylipid-formation inhibiting activity and useful for the prevention of obesity, and the prevention and treatment of hyperlipemia, arteriosclerosis, cardiomy...
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JP2001503732A |
Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have...
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JP3141071B2 |
PURPOSE: To obtain an agent for lowering side effect of Plecotus auritus having cardiac action, comprising barrenwort, crude medicine widely used for the purpose of robustness and energy from ancient times or its essence as an active ing...
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JP2001039998A |
To obtain the subject agent useful as a suppressant or therapeutic agent for skin cancer, suppressant or therapeutic agent, etc. for liver cancer by constituting the agent of a composition comprising a specific triterpenoid saponin as an...
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JP3128579B2 |
PURPOSE: To enable mass-production of the subject compound which is useful in the metabolic study of catechol estrogen in high yield at low costs by glycosylation of 2-acetyl-estrogen followed by Bayer-Villiger oxidation and deprotection...
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JP3123745B2 |
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JP2000302798A |
To obtain the subject composition capable of protecting a damaged brain for a long period of time by showing excellent promoting action on cerebral blood vessel reproduction and restructuring by intravenous administration after apoplexy ...
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JP2000514046A |
A method of treating supraventricular arrhythmia and/or atrial fibrillation using a safe and effective amount of deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds and the pharmaceutically acceptable acid, salts or e...
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JP2000513380A |
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable o...
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JP2000281698A |
To provide a new compound that has a carcinostatic activity specifically inhibiting the proliferation of cancer cells or the activity of inducing the apoptosis of cancer cells and is useful for treating cancers. This new compound is furc...
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JP2000256390A |
To obtain a medicine composition useful for treating diseases related to estrogen and androgen by making the composition include a pharmacologically acceptable diluent, or the like, and a specific sex steroid activity inhibitor. This com...
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JP2000191539A |
To obtain the subject compound for accelerating expression of cell death suppressing gene product Bcl-xL by containing ginsenoside Rb1. This protective agent for brain cells and nerve cells is brought to contain ginsenoside Rb1 (a compou...
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JP3049504B2 |
Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatlc steroids and their use in treating ocular hypertension, including controlling the ocular hypertension associate...
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JP3048636B2 |
PCT No. PCT/EP91/02494 Sec. 371 Date Jun. 22, 1993 Sec. 102(e) Date Nov. 1, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11278 PCT Pub. Date Jul. 9, 1992.Novel compounds of the general formula I (I) and the pharmacologically tolerable ...
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JP3036141B2 |
PURPOSE: To provide the title novel compound having high nonlinear optical performance for wavelength transformation, etc., thus useful for nonlinear optical materials and nonlinear optical elements. CONSTITUTION: The objective compound ...
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JP3034410B2 |
PURPOSE: To obtain the glycoside, expressed by a specific formula, having excellent hair producing and growing effects and safety capable of sufficiently withstanding the use for a long period and useful as a hair producing and growing a...
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JP3034095B2 |
PURPOSE: To obtain a catecholestrogen glycoside having durable inhibitory action on formation of peroxide lipid, improved water solubility and stability. CONSTITUTION: A catecholestrogen glycoside of formula I (R1 is H, glucosyl, etc.; R...
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JP3034411B2 |
PURPOSE: To obtain the glycoside, expressed by a specific formula, having excellent hair producing and growing effects and safety capable of sufficiently withstanding the use for a long period and useful as a hair producing and growing a...
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JP3034412B2 |
PURPOSE: To obtain the glycoside, expressed by a specific formula, having excellent hair producing and growing effects and safety capable of sufficiently withstanding the use for a long period and useful as a hair producing and growing a...
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JP2000502994A |
The present invention relates to a vasodilating composition comprising ginsenoside Rg3 and/or Rg5, one of the saponin components of ginseng, as an active ingredient. Since ginsenoside Rg3 and Rg5, the active ingredient of the composition...
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JP2000044593A |
To obtain an ACAT inbibitor having acylcoenzyme A cholesterol acyltransferase(ACAT) inhibitory activity and suitable in e.g. preventing/treating arteriosclerosis by including a specific saponin. This ACAT inhibitor is obtained by includi...
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JP2975705B2 |
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JPH11512402A |
The invention is directed to compounds, compositions and method of preparation of compounds of formulae I and II:wherein X, Q1, Q2, R1 and R2 are as defined by the specification. The compounds are disclosed as useful cholesterol-lowering...
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JPH11286447A |
To obtain an aerosol medicine used for the oral inhalation treatments of airway passage and lung diseases, such as asthma by including mometasone furoate. This aerosol medicine contains mometasone furoate preferably in the form of dry po...
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JP2959839B2 |
Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified her...
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JP2956776B2 |
There are provided 13-alkyl-11beta-phenyl-gonanes of formula I (I) wherein Z is an oxygen atom or N-OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl radicals, a...
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JP2951657B1 |
[wrap up] [Task] Provided is a substance capable of promoting the absorption of iron citrate in the brain and improving the cure rate thereof, which is effective for the treatment of patients with Alzheimer's disease. General formula [Ch...
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JP2947944B2 |
Compounds of the androstane series are described having general formulaand solvates thereof, in which R1 represents O, S or NH; R2 individually represents OC(=O)C1-6 alkyl; R3 individually represents hydrogen, methyl (which may be in eit...
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JPH11240836A |
To obtain the subject composition capable of solubilizing a hydrophobic steroidal compound, enabling formation of preparation as an injection, capable of promoting absorbing property of an oral agent, or the like and useful as an antitum...
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JPH11199598A |
To obtain a ursodeoxycholic acid derivative having improved solubility in water and to provide a method for producing the derivative. This ursodeoxycholic acid derivative is obtained by bonding a saccharide through a spacer to ursodeoxyc...
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JP2921989B2 |
PCT No. PCT/EP95/02921 Sec. 371 Date Jun. 13, 1996 Sec. 102(e) Date Jun. 13, 1996 PCT Filed Jul. 24, 1995 PCT Pub. No. WO96/03423 PCT Pub. Date Feb. 8, 1996The invention concerns a process for the production of hapten-labelled peptides w...
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JP2911553B2 |
Compounds of the general formula I have been described in which X, R<1>, R<2>, R<3> and R<4> have the meaning stated in the description, as well as processes for the preparation thereof, pharmaceutical products containing these compounds...
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JPH11130679A |
To obtain the subject liquid which is excellent in the penetration of a glucocorticoid to nails and the effective rate in vivo, contains no additional solvent or substance promoting diffusion or penetration and is useful as a medicine fo...
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JPH11124393A |
To prepare a pharmaceutical composition for preventing or reducing the loss of tissue vitality caused by adhesion of neutrophils to endothelial cells in a patient having a tissue injury by using dehydroepiandrosterone-3-sulfate or the li...
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