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Matches 1 - 50 out of 428

Document Document Title
WO/2022/145459A1
The present invention addresses the problem of providing a compound having Nrf2-activation action. Provided are: compounds represented by general formula (I), or compounds of the lower-polarity group among two groups of diastereomers in ...  
WO/2022/143479A1
Provided are a solid form of a compound, a preparation method therefor and the use thereof, which belong to the field of pharmaceutical chemistry. The solid form comprises a co-crystal of the compound and cinnamamide, or a tromethamine s...  
WO/2022/119823A1
Positive allosteric modulators (PAMs) of Mas-related G protein-coupled receptor X1 (MRGPRX1) and their use for treating neuropathic pain is disclosed.  
WO/2022/105636A1
Disclosed are a spiro compound, a pharmaceutical composition containing same, and the use thereof. The spiro compound interferes with interaction between the protein menin and MLL1, MLL2 or MLL fusion oncoproteins, and is expected to be ...  
WO/2022/038066A1
The present invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing these compounds.  
WO/2021/238587A1
A micromolecular oxathiazine derivative, which belongs to the field of organic synthesis medicines and has the general formula as shown below: the micromolecular oxathiazine derivative can be used as a positive allosteric modulator of an...  
WO/2021/238588A1
An oxathiazine compound, of which the general formula is as follows. The oxathiazine compound can be used as a positive allosteric modulator of an AMPA receptor, and can positively modulate the AMPA receptor and make the conformation mor...  
WO/2021/229152A1
The present invention relates to a compound of formula (I) or (II) wherein R1, R2, R3, R4, R5, R23, R24, R25, R26, R27, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of fo...  
WO/2021/226003A1
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related disea...  
WO/2021/180181A1
A class of pyrimidoheterocyclic compounds, and specifically disclosed is a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.  
WO/2021/170774A1
A compound of formula (I) : wherein Z, Y1,Y2,(Formula II)R1 to R7 are as defined in the description, its optical isomers, and addition salts thereof with a pharmaceutically acceptable base. Medicaments.  
WO/2021/143821A1
A fused heteroaryl derivative, a preparation method therefor, and an application thereof in medicine. In particular, provided are a fused heteroaryl derivative as shown in general formula (I-1), a preparation method therefor, a pharmaceu...  
WO/2021/063967A1
The present invention relates to a compound of the formula (I) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a -COR4 group, (2) a...  
WO/2021/037401A1
The invention relates to dibenzofuran derivatives which are substituted with electron-poor heteroaryl groups, and to electronic devices, in particular organic electroluminescent devices containing said compounds as triplet matrix materials.  
WO/2021/018237A1
Provided are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well a...  
WO/2021/002473A1
The invention addresses the problem of providing a compound having Nrf2-activation action. The invention is the compound represented by general formula (I), a salt thereof, or a solvate thereof. General formula (I): In the formula: R1a a...  
WO/2020/226295A1
The present invention provides: a compound represented by chemical formula 1; an organic electric element comprising a first electrode, a second electrode, and an organic layer placed between the first electrode and the second electrode;...  
WO/2020/208509A1
The present invention discloses a compound of formula (I), wherein, R1, L1,A, k, L2, W, L4, R5, R8 and R9 are as defined in the detailed description. The present invention further discloses a process for preparing the compound of formula...  
WO/2020/208511A1
The present invention discloses a compound of formula (I), Formula (I) wherein, R1, L1,A, L2, W1, R2f, R3f, Q, and R10 are as defined in the detailed description. The present invention also relates to a process for preparing the compound...  
WO/2020/146470A1
The present invention provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Such target proteins can be any protein involved in the pathway of a disease or disorder, such as but not l...  
WO/2020/132648A1
Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related...  
WO/2020/128925A1
The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing ...  
WO/2020/103897A1
A heterocyclic fused pyrimidine derivative, a pharmaceutical composition thereof, and an application thereof. A heterocyclic fused pyrimidine derivative (I), and an isomer, prodrug, stable isotope derivative, or pharmaceutically acceptab...  
WO/2020/064002A1
The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound ...  
WO/2020/041169A2
Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as...  
WO/2020/021215A1
The present invention relates to deuterated derivatives of lanifibranor, in particular for use in therapy, specifically in the treatment of fibrotic diseases.  
WO/2019/164301A1
The present specification provides a compound of chemical formula 1 and an organic light emitting diode comprising same.  
WO/2019/122393A1
The present disclosure relates to the use of hydroxyisoxazolines and derivatives thereof as fungicide. It also relates to new hydroxyisoxazolines derivatives, their use as fungicide and compositions comprising thereof.  
WO/2019/123007A1
Disclosed is an aryl hydrocarbon receptor modulator of formula (I), and a pharmaceutically acceptable salt thereof, wherein R' is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, formula (IV), formula (II), or formula (II); the two Ra are in...  
WO/2019/121541A1
The invention relates to substituted N-heterocyclyl- and N-heteroaryl-tetrahydropyrimidinones of general formula (I) or the salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use of...  
WO/2019/080227A1
The present invention relates to the technical field of pesticides, and in particular to a substituted benzoyl isoxazole compound or a tautomer and a salt thereof, a preparation method, a herbicide composition and an application. The sub...  
WO/2019/081485A1
The invention relates to substituted pyrazoles of general formula (I) or salts thereof, wherein the groups of general formula (I) are defined as cited in the description, and to the use thereof as herbicides, in particular for controllin...  
WO/2019/079632A1
Disclosed herein are methods of treating a tumor or cancer in a subject whose tumor or cancer cells express low levels of asparagine synthetase (ASNS), and compounds and compositions useful in such treatment. Also disclosed herein are me...  
WO/2019/016781A1
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and use thereof for prevention and/or treatment of microbial infections and/or related diseases or conditions. The ...  
WO/2019/016782A1
Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and use thereof for prevention and/or treatment of microbial infections and/or related diseases or conditions. The ...  
WO/2018/202654A1
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, (formula X) wherein the variables of compound of formula X are as defined in the claims and the description.  
WO/2018/177970A1
The present invention relates to pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof, their mixtures and to compositions comprising such compounds or mixtures. The invention also relates to ...  
WO/2018/166934A1
The present invention relates to dibenzofuran and dibenzothiophene derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compound...  
WO/2018/114596A1
The invention relates to substituted heteroaryl pyrrolones of general formula (I) and salts thereof, wherein the groups of general formula (I) are defined as cited in the description, and to the use thereof as herbicides, in particular f...  
WO/2018/109649A1
The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and...  
WO/2018/109642A1
The present invention relates to N-aryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formul...  
WO/2018/019574A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2018/014829A1
The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossif...  
WO/2018/007323A1
The present disclosure relates to fungicidal active compounds of formula (I), more specifically to benzosultams and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, part...  
WO/2017/153234A1
The invention relates to new substituted N-Cyclo-2-aryl-quinoline-4-carboxamide derivatives, to methods for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases and to their us...  
WO/2017/147526A1
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathoge...  
WO/2017/099516A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present disclosure is capable of producing an...  
WO/2017/096472A1
Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or...  
WO/2017/092473A1
Provided are a compound with connected indole heterocycles, and a mixture, a composition, an organic electronic device containing the compound, and a use. In certain preferred embodiments, the hydrogen atom in a C-H bond on a indolocarba...  
WO/2017/044571A1
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus : The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP...  

Matches 1 - 50 out of 428