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WO/2024/085235A1 |
The present invention discloses a method for producing cyclic peptide crystals, the method comprising bringing a cyclic peptide into contact with a specific solvent.
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WO/2024/086781A2 |
According to some aspects, systems and methods for characterizing phosphoserine-containing polypeptides are described. In some embodiments, a phosphoserine residue of a polypeptide may be converted to a dehydroalanine residue. Some aspec...
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WO/2024/082609A1 |
A device for preparing a bioactive peptide. The device comprises a preparation box (1) mounted on a supporting frame body, wherein a net cover (2) having two ends in communication with each other is fixedly mounted in the preparation box...
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WO/2024/044679A3 |
This disclosure describes methods of site-specific modification of peptides for conjugation, and more particularly methods for synthesizing peptides with N-terminal cysteine and uses of the same.
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WO/2024/015853A3 |
Disclosed herein are fusion proteins comprising the CR3 domain of the low density lipoprotein (LDLR) and a polypeptide with phase behavior. Also provided herein are polypeptides with phase behavior. Additionally provided herein are metho...
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WO/2024/078578A1 |
The present invention belongs to the technical field of oligosaccharides and glycoconjugates thereof, and specifically relates to a sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, a glycoconjugate and a prep...
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WO/2024/081963A2 |
Described are labeling kits for proximity labeling of biomolecules. A kit may include a plurality of first tagged spacer precursors, a plurality of second tagged spacer precursors, a plurality of tagged enzymes, and a plurality of connec...
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WO/2024/081302A1 |
A method of covalently modifying tyrosines, tryptophans, and pyrrolated lysines in a protein comprising reacting the side chains of the amino acids with a cyclic imine Mannich electrophile appended to a ligand that binds to the protein; ...
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WO/2024/078487A1 |
Provided herein are methods for modifying an antibody by attaching a molecule with a functional handle to the antibody.
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WO/2024/080933A1 |
The invention relates to a method of separating protein fractions from a protein sample comprising the steps of dispersing the protein sample in a deep eutectic solvent to form a dispersion, treating the dispersion with elevated temperat...
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WO/2024/080333A1 |
The present inventors found that a target cyclic peptide compound can be efficiently produced while preventing epimerization and reducing multimer formation, by linking the N-terminal amino acid residue with the C-terminal amino acid res...
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WO/2024/081928A1 |
The present invention relates to a hemoglobin protein composition comprising biologically active hemoglobin and less than 2% methemoglobin (metHb) wherein the metHb is maintained below 2% after reoxygenation of hemoglobin. Furthermore, h...
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WO/2024/075024A1 |
This invention relates to methods for purifying type II collagen from cartilage tissue. The present invention also relates to a type II collagen composition, and the use of the type II collagen composition as a dietary supplement or trea...
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WO/2024/075813A1 |
Provided are: a novel diketopiperazine compound for rapid and easy synthesis of various polypeptides; and a method for manufacturing the same. The diketopiperazine compound is represented by general formula (1). (In the formula, R1, R2, ...
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WO/2024/074159A1 |
A method for preparing a small-molecule ass-hide glue polypeptide product. The method comprises the following steps: S1. pretreatment of ass-hide glue: crushing ass-hide glue blocks as raw materials, dissolving same by adding water, perf...
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WO/2024/077083A2 |
The present disclosure provides compositions and methods related to the purification and/or isolation of antibodies. In particular, the present disclosure provides novel peptide ligands capable of targeting the fragment antigen binding (...
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WO/2024/071960A1 |
The present invention relates to: a peptide tag based on a dispersed His-tag and charged and hydrophobic amino acids forming a self-assembly; a fusion protein in which the tag and a target protein are fused; and a target protein purifica...
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WO/2024/067531A1 |
Provided is a dual-targeting compound against FAP and integrin αvβ3. The targeting compound and a radionuclide marker thereof can synergistically target a FAP target and an integrin αvβ3 target in tumors, such that the number of and ...
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WO/2024/068683A1 |
A stationary phase for use in affinity chromatography for recovering adeno-associated virus (AAV) vectors (3) from a solution. The stationary phase comprises a porous polymer matrix (1) having a mean flow pore size of 0.1-2.0 µm, wherei...
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WO/2024/071956A1 |
The present invention relates to a fusion polypeptide and a method for purifying a target protein by using same, the polypeptide having any one from among a His tag, a HAT tag and an HQ tag, and an α-helix peptide tag of which the major...
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WO/2024/071320A1 |
The present invention provides a method with which it is possible to simply produce a peptide including an aromatic six-membered ring in the scaffold. The present invention pertains to a production method for a compound represented by fo...
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WO/2024/067535A1 |
Provided are a small peptide and a use thereof in mucosal repair. The small peptide is selected from a basic small peptide having a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2 or a lead small peptide containing the basic small pept...
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WO/2024/071008A1 |
The present invention addresses the problem of providing a method in which an antigen molecule is efficiently isolated from and detected in an antigen-antibody complex in a biological specimen. Provided is a method which isolates an an...
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WO/2024/073442A1 |
Disclosed are methods for isolating full-length intercellular proteins from a complex, multicellular environment. The disclosed methods include growing cells in the complex environment in the presence of an amino acid or alkanoic acid an...
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WO/2024/068682A1 |
The present disclosure provides a chromatography ligand defined by Formula I: wherein: X1 is selected from CO and SO2; each of R1-R5 is independently selected from H, F, Cl, O, N, S, C1-3 alkyl, and C1- 3 alkyl-X2; any two adjacent moiet...
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WO/2024/071964A1 |
The present invention relates to: a fusion polypeptide in which a His tag is fused with a peptide tag having main amino acids composed of charged and polar amino acids; a fusion protein in which the fusion polypeptide is fused with a tar...
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WO/2024/071957A1 |
The present invention relates to an amorphous peptide tag with main amino acids composed of charged and hydrophobic amino acids, a fusion protein in which the tag is fused with a target protein, and a method for purifying the target prot...
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WO/2024/066540A1 |
The present application relates to an aspartic acid protease targeted recognition PET molecular probe and use, which pertain to the technical field of chemistry. The present application provides a molecular probe. In the molecular probe,...
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WO/2024/071970A1 |
The present invention relates to: a fusion polypeptide comprising a His tag, and a peptide tag of which the main amino acids are charged amino acids; a fusion protein in which the fusion polypeptide and a target protein are fused; and a ...
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WO/2024/066351A1 |
An extraction and multi-scenario utilization method for flaxseed protein-polysaccharide natural blends, comprising: (1) raw material pretreatment; (2) extraction of a blend I; (3) multi-scenario utilization of the blend I; (4) extraction...
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WO/2024/060196A1 |
Provided are an RNA reaction type fluorescent probe (9), a preparation method therefor, and use thereof in tumor imaging and treatment. After the probe (9) is responded by an ALP enzyme, the fluorescence thereof is enhanced, and a photo-...
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WO/2024/062149A1 |
The present invention relates to compounds, especially to conjugates and derivatives of alternariol labelled at specific positions in the molecule, suitable for the production of antibodies with a high affinity for alternariol. Likewise,...
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WO/2024/060507A1 |
The present invention relates to the field of efficient utilization of biological resources. Disclosed is an aquatic protein pretreatment method. According to the method, an aquatic protein is pretreated by using a dense phase carbon dio...
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WO/2024/063469A1 |
The present invention is related to a method for purifying heparan-N-sulfatase from a heparan-N-sulfatase-containing solution including at least one impurity, the method comprising performing multi-mode chromatography (MMC) to obtain an ...
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WO/2024/064309A1 |
A method for selectively isolating lower immunogenic biomolecule-polymer conjugates from an initial source of biomolecule-polymer conjugate, the method comprising eluting the initial source of biomolecule-polymer conjugate through a hydr...
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WO/2024/061639A1 |
The present invention relates to a method for removing free polymers present in a solution containing a hydrophobic protein, wherein the method comprises: (a) contacting the solution containing the free polymers not bound to the hydropho...
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WO/2024/058924A1 |
A process for deprotecting a protected amino acid during solid phase peptide synthesis (SPPS) includes removing a protecting group of a protected amino acid in a reaction vessel with a deprotecting base present in the reaction vessel in ...
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WO/2024/058951A1 |
Provided herein are methods of determining the reduction susceptibility of a protein and methods of adjusting the culturing condition of the protein based on the reduction susceptibility.
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WO/2024/056626A1 |
The present invention relates to a method for separating a product of interest from impurities and an apparatus for performing the method. The method comprises the steps in the indicated order: (1) loading on a chromatography matrix a fi...
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WO/2024/059235A2 |
The disclosure provides methods of purifying a target protein, e.g., an antibody, from a host cell such as a mammalian cell using purification protocols incorporating harvest recovery operations comprising a continuous solids discharge d...
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WO/2024/057361A1 |
The present invention develops a method involving: solubilizing, without using a modifying agent, an insoluble protein included in an inclusion body, which is aggregate of a recombinant protein expressed in a microorganism; separating sa...
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WO/2024/058110A1 |
This method for purifying an antibody comprises preparing a solution containing an antibody, and filtering the solution using a porous membrane containing regenerated cellulose to purify the antibody. This method for purifying an antibod...
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WO/2024/055988A1 |
Provided are an isolated polypeptide consisting of a mutant B domain of Protein A, an unnatural immunoglobulin binding protein containing the mutant B domain, a conjugate containing the mutant B domain or the unnatural immunoglobulin bin...
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WO/2024/051616A1 |
Provided is a polypeptide, which has: (I) an amino acid sequence set forth in any one of SEQ ID No. 1, SEQ ID No. 4, and SEQ ID No. 5; or (II), an amino acid sequence obtained by substitution, deletion, or addition of one or more amino a...
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WO/2024/054992A1 |
The present disclosure is directed to methods of separating a chelator from a mixture and measuring the concentration of the chelator in the mixture using a chromatography column. Such methods can be useful in adjusting the concentration...
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WO/2024/052938A1 |
The present invention relates to a process for the production and purification of recombinant, untagged, trimeric SARS-CoV-2 spike protein. The present invention discloses the process of production recombinant SARS-CoV-2 spike protein yi...
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WO/2024/044852A1 |
Described herein is a high-throughput method of synthesizing biofunctional microparticles. In aspects, the method comprises casting biofunctional microparticle precursors onto a microporous template to form microparticles, wherein the te...
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WO/2024/048050A1 |
According to the present disclosure, provided is a carrier peptide fragment having excellent cell membrane permeability. The disclosed carrier peptide fragment comprises an amino acid sequence represented by SEQ ID NO: 1, KKRTLRKSNRKKR, ...
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WO/2024/045430A1 |
The present invention relates to the technical field of biological functions of proteins, and specifically relates to a polypeptide, a fused polymer protein and the use thereof. The polypeptide is selected from: (1) a polypeptide that ha...
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WO/2024/046404A1 |
A recombinant botulinum toxin and a preparation method therefor. By designing and optimizing the heavy chain and light chain sequences of the recombinant botulinum toxin, adding and cleaving protein tags will not introduce amino acid res...
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